Delayed presentation of paracetamol overdose

Retief, Johnre; Taljaard, Luan; Strover, Bruce

doi:10.1016/j.afjem.2020.02.003

Cited by 3 publications

(3 citation statements)

References 9 publications

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“…This case report revealed that while NAC has been suggested to be an effective antidote for early phases, the use of it in late toxicity is also gaining importance 18 . Furthermore, successful treatment with prolonged infusion of NAC was reported in a 22‐year‐old female with encephalopathy due to acetaminophen toxicity 19 . Meanwhile, our reported case was recovered with the standard regimen.…”

Section: Discussionmentioning

confidence: 67%

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Late N‐acetylcysteine for successful recovery of acetaminophen‐related acute liver failure: A case report

Alizadeh,

Yaryari,

Behnoush

et al. 2023

Clinical Case Reports

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Acetaminophen toxicity is one of the leading causes of liver failure. Although N‐acetylcysteine (NAC) is generally successful in preventing acetaminophen hepatotoxicity when given in a timely manner, if not prescribed in the early golden time, the only practical way to save the patient might be liver transplantation. The case presented was a 20‐year‐old female with an acetaminophen overdose (30 g), for which more than 24 h had passed since the ingestion. Despite the critical clinical condition, loss of consciousness (Glasgow Coma Score of 4) of the patient, and passing the golden time of antidote administration, the decision was made by the healthcare team to administer NAC. After transferring the patient to the intensive care unit, the three‐bag NAC regimen was initiated and appropriate monitoring was performed. After this, the regimen of 3 g q8h was continued for the patient. The patient's condition began to improve slowly on the second day and then she was extubated on the fourth day. Finally, she was discharged on the tenth day. Although the golden period of antidote administration had passed outwardly, there was no need for a liver transplant and the patient recovered successfully with late NAC administration. Hence, clinicians can benefit from the use of NAC even in the late phases of acetaminophen liver toxicity.

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Section: Discussionmentioning

confidence: 67%

“…18 Furthermore, successful treatment with prolonged infusion of NAC was reported in a 22-year-old female with encephalopathy due to acetaminophen toxicity. 19 Meanwhile, our reported case was recovered with the standard regimen. NAC administration may improve survival even at this stage.…”

Section: At Admissionmentioning

confidence: 85%

Late N‐acetylcysteine for successful recovery of acetaminophen‐related acute liver failure: A case report

Alizadeh,

Yaryari,

Behnoush

et al. 2023

Clinical Case Reports

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“…DSP is used as a means of gaining attention, expressing one’s feelings, or retaliating against someone. Both parasuicides and DSP require the same level of attention as suicide attempts [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

The Applicability of Linehan Risk Assessment Scale: a Cross-Sectional Study from Alexandria Poison Centre, Egypt, During the COVID-19 Pandemic

Salam

Dine

Kerim

et al. 2022

SN Compr. Clin. Med.

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Background/Objective Suicide is a critical health problem that is significantly rising during the COVID-19 pandemic worldwide, yet it is still under-reported in Egypt. To date, a deficiency of a reliable scale to probe the risk factors underlying suicide liability among patients with deliberate self-poisoning. The study’s objective was to offer a snapshot of the pattern of self- poisoning in Egypt during the COVID-19 pandemic. Methods Using the Linehan Risk Assessment and Management Protocol LRAMP, a psychological assessment was applied to evaluate vulnerable patients needing urgent psychiatric support and emphasize the influence of previous suicidal behaviors. A cross-sectional study was conducted on all patients admitted to Alexandria Poison Centre with deliberate self-poisoning biosocial and poisoning data that were recorded in a specially designed sheet. All patients were interviewed for underlying risk factors and protective factors for suicidal behavior. Results Significant relation was recorded between previous suicidal attempts and psychiatric diseases. CNS depressant drugs and rodenticides recorded the highest frequency. The calculated score (suicide and protective factors) was higher in patients with previous suicidal attempts. Conclusion The study was the first to test the applicability of Linehan scale in Alexandria Poison Centre. The results are promising; however, multicenter replication of the concluded findings will be valuable.

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Paracetamol overdose

2020

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Delayed presentation of paracetamol overdose

Cited by 3 publications

References 9 publications

Late N‐acetylcysteine for successful recovery of acetaminophen‐related acute liver failure: A case report

Late N‐acetylcysteine for successful recovery of acetaminophen‐related acute liver failure: A case report

The Applicability of Linehan Risk Assessment Scale: a Cross-Sectional Study from Alexandria Poison Centre, Egypt, During the COVID-19 Pandemic

Paracetamol overdose

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