Delayed presentation of invasive thymoma in myasthenia gravis: A case report

Galizia, Elizabeth Caruana; Farrugia, Maria Elena; Swingler, Robert

doi:10.1016/j.nmd.2011.01.002

Cited by 3 publications

(4 citation statements)

References 8 publications

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“…Overall, routine radiological examination had relatively high sensitivity and specificity for thymoma. Because a thymoma may be missed on initial imaging, the clinician must be alert to the possible later clinical presentation of thymoma in patients with MG . In clinically suspicious cases, follow‐up imaging should be considered, especially if the patient has not undergone thymectomy.…”

Section: Discussionmentioning

confidence: 99%

Thymus imaging in myasthenia gravis: The relevance in clinical practice

et al. 2018

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Section: Discussionmentioning

confidence: 99%

Thymus imaging in myasthenia gravis: The relevance in clinical practice

et al. 2018

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“…Galizia reported the delayed occurrence of an invasive thymoma 11 years after a normal CT scan. 6 Frequent thoracic imaging is required in MG, especially when the patient is positive for anti-Kv1.4 antibodies, because anti-Kv1.4 antibodies are frequently detected in thymoma-associated MG. 9 Even benign thymomas, such as those with World Health Organization B1 histology, might develop and grow within 1 year. Considering the time-course of the present case, annual follow up is recommended.…”

Section: Discussionmentioning

confidence: 99%

“…It was fortunate for the patient that thoracic imaging studies were carried out annually and eventually detected the newly developed thymoma. Galizia reported the delayed occurrence of an invasive thymoma 11 years after a normal CT scan . Frequent thoracic imaging is required in MG, especially when the patient is positive for anti‐Kv1.4 antibodies, because anti‐Kv1.4 antibodies are frequently detected in thymoma‐associated MG .…”

Section: Discussionmentioning

confidence: 99%

“…However, little is known about the follow-up status of thoracic imaging in patients with MG. Thymomas occasionally relapse, and in uncommon cases, they develop in patients who were initially negative. 6 In older adult patients, extrathymic malignancies are also a matter of concern. Follow-up thoracic imaging might also have findings outside the scope of thymic follow up.…”

Section: Introductionmentioning

confidence: 99%

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Significance of follow‐up thoracic imaging in myasthenia gravis

Murai

Nagane

Suzuki

et al. 2018

Clinical & Exp Neuroim

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Objectives Most patients with myasthenia gravis (MG) undergo thoracic imaging at initial diagnosis. However, the follow‐up protocol is unclear. The objective of the present study was to clarify the follow‐up status and main findings of thoracic imaging in patients with MG. Methods A total of 649 patients with disease duration ≥1 year were included in the study. The follow‐up rate and time from the initial scan to the latest thoracic imaging were evaluated. The rate of abnormality and details of abnormal findings in both non‐thymomatous MG and thymoma‐associated MG were investigated. Results The follow‐up thoracic imaging rate of 145 patients with thymoma‐associated MG was 71.7%, whereas just 46.2% of 504 patients with non‐thymomatous MG underwent follow‐up imaging. Abnormal findings were detected in 8.6% of patients with non‐thymomatous MG and 26.0% of those with thymoma‐associated MG. Abnormal findings included cancer, lung infection and lymph node swelling in the former, and relapse or increased size of thymoma in the latter. Conclusions Frequent follow up by thoracic imaging is necessary in patients with MG.

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