Delayed-onset Ureteral Obstruction and Calcification Masquerading as Renal Colic Following Deflux Injection

Romain, Julie; Fourcade, Laurent; Centi, J.; Blanc, P; Masselin, Mathilde Casson; Lescure, V.; Guigonis, Vincent; Descazeaud, A.; Ballouhey, Quentin

doi:10.1016/j.urology.2016.03.001

Cited by 13 publications

(1 citation statement)

References 11 publications

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“…Because delayed ureteral obstruction may occur as long as 5 years after injection therapy, it can be missed, resulting in silent loss of renal function. In addition, the calcification of injection material may be misdiagnosed as ureteral stones, because the density of Dx/HA implants on CT scans increases over time, appearing as progressive histopathologic changes [6768]. …”

Section: Current Trend and Debates On Endoscopic Injectionmentioning

confidence: 99%

Endoscopic injection therapy

Kim

Lee

2017

Investig Clin Urol

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Since the U.S. Food and Drug Administration approved dextranomer/hyaluronic acid copolymer (Deflux) for the treatment of vesicoureteral reflux, endoscopic injection therapy using Deflux has become a popular alternative to open surgery and continuous antibiotic prophylaxis. Endoscopic correction with Deflux is minimally invasive, well tolerated, and provides cure rates approaching those of open surgery (i.e., approximately 80% in several studies). However, in recent years a less stringent approach to evaluating urinary tract infections (UTIs) and concerns about long-term efficacy and complications associated with endoscopic injection have limited the use of this therapy. In addition, there is little evidence supporting the efficacy of endoscopic injection therapy in preventing UTIs and vesicoureteral reflux-related renal scarring. In this report, we reviewed the current literature regarding endoscopic injection therapy and provided an updated overview of this topic.

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Section: Current Trend and Debates On Endoscopic Injectionmentioning

confidence: 99%