Delayed myelination in children with developmental delay detected by volumetric MRI

Pujol, Jesús; López-Sala, Anna; Sebastián‐Gallés, Núria; Deus, Joan; Cardoner, Narcı́s; Soriano‐Mas, Carles; Moreno, Àngel; Sans, Anna

doi:10.1016/j.neuroimage.2004.01.029

Cited by 51 publications

(44 citation statements)

References 36 publications

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“…Several previous studies have demonstrated that WM abnormalities are a common feature of 22q11.2DS (Barnea-Goraly et al, 2003;Campbell et al, 2006;Eliez et al, 2000;Kates et al, 2001;Simon et al, 2005;van Amelsvoort et al, 2004) and also in children with idiopathic developmental delay (Fayed et al, 2006;Pujol et al, 2004). The present study shows that there is abnormal longitudinal development of WM in 22q11.2DS children.…”

Section: Discussionmentioning

confidence: 98%

Developmental trajectories of brain structure in adolescents with 22q11.2 deletion syndrome: A longitudinal study

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Penniman

et al. 2007

Schizophrenia Research

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The 22q11.2 deletion syndrome (22q11.2DS) is associated with very high rates of schizophrenialike psychosis and cognitive deficits. Here we report the results of the first longitudinal study assessing brain development in individuals with 22q11.2DS. Twenty-nine children with 22q11.2DS and 29 age and gender matched controls were first assessed during childhood or early adolescence; Nineteen subjects with 22q11.2DS and 18 controls underwent follow-up during late adolescenceearly adulthood. The 22q11.2DS subjects showed greater longitudinal increase in cranial and cerebellar white matter, superior temporal gyrus, and caudate nucleus volumes. They also had a more robust decrease in amygdala volume. Verbal IQ (VIQ) scores of the 22q11.2DS group that developed psychotic disorders declined significantly between assessments. Decline in VIQ in 22q11.2DS was associated with more robust reduction of left cortical grey matter volume. No volumetric differences were detected between psychotic and nonpsychotic subjects with 22q11.2DS. Brain maturation associated with verbal cognitive development in 22q11.2DS varies from that observed in healthy controls. Further longitudinal studies are likely to elucidate brain developmental trajectories in 22q11.2DS and their association to psychotic disorders and cognitive deficits in this population.

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Section: Discussionmentioning

confidence: 98%

Developmental trajectories of brain structure in adolescents with 22q11.2 deletion syndrome: A longitudinal study

Gothelf

Penniman

et al. 2007

Schizophrenia Research

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“…Given this progression over distinct brain areas, one can speculate that those infants whose brain development is more advanced than others, in terms of the degree of myelination, may attain certain cognitive abilities earlier than their agematched counterparts with less developed myelination. In fact, a number of developmental disorders, including holoprosencephaly, show slower progression of myelination as compared to normally developing children (Barkovich et al, 2002;Dietrich et al, 1988;Pujol et al, 2004). However, individual differences in the degree of myelination and concurrent cognitive ability have not yet been studied.…”

Section: Structural Development Of the Infant Brainmentioning

confidence: 99%

Development of structure and function in the infant brain: Implications for cognition, language and social behaviour

Paterson

Heim

Friedman

et al. 2006

Neuroscience & Biobehavioral Reviews

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Recent advances in cognitive neuroscience have allowed us to begin investigating the development of both structure and function in the infant brain. However, despite the rapid evolution of technology, surprisingly few studies have examined the intersection between brain and behaviour over the first years of life. Even fewer have done so in the context of a particular research question. This paper aims to provide an overview of four domains that have been studied using techniques amenable to elucidating the brain/behaviour interface: language, face processing, object permanence, and joint attention, with particular emphasis on studies focusing on early development. The importance of the unique role of development and the interplay between structure and function is stressed throughout. It is hoped that this review will serve as a catalyst for further thinking about the substantial gaps in our understanding of the relationship between brain and behaviour across development. Further, our aim is to provide ideas about candidate brain areas that are likely to be implicated in particular behaviours or cognitive domains.

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“…Once again, findings are mixed. Previous studies in children with developmental delay showed reduced myelination, (Pujol et al, 2004). Reduced WM volume was detected in subjects with ADHD (Castellanos et al, 2002).…”

Section: What Is the Pathology Underlying Abnormal White Matter Develmentioning

confidence: 76%

Abnormal Developmental Trajectories of White Matter in Autism - The Contribution of MRI

Bashat¹

2011

Autism - A Neurodevelopmental Journey From Genes to Behaviour

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Delayed myelination in children with developmental delay detected by volumetric MRI

Cited by 51 publications

References 36 publications

Developmental trajectories of brain structure in adolescents with 22q11.2 deletion syndrome: A longitudinal study

Developmental trajectories of brain structure in adolescents with 22q11.2 deletion syndrome: A longitudinal study

Development of structure and function in the infant brain: Implications for cognition, language and social behaviour

Abnormal Developmental Trajectories of White Matter in Autism - The Contribution of MRI

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