Delayed Meconium Passage in Very Low Birth Weight Infants

Arnoldi, Rossella; Leva, Ernesto; Macchini, Francesco; Cesare, Antonio Di; Colnaghi, Mariarosa; Fumagalli, Monica; Mosca, Fabio; Torricelli, Michela

doi:10.1055/s-0031-1291301

Cited by 21 publications

(14 citation statements)

References 3 publications

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“…[1][2][3] The incidence appears to be inversely correlated with gestational age and as many as 80% of infants b 34 weeks estimated gestational age (EGA) fail to pass meconium within 48 h of birth. [4] Hirschsprung Disease (HD) is typically considered after persistent absence of a bowel movement in the setting of abdominal distention. Once thought to be uncommon in premature infants, recent studies confirm that the incidence is the same in preterm and term neonates at approximately 1 in 5000.…”

mentioning

confidence: 99%

Suction Rectal Biopsy is Accurate in Late Preterm Infants with Suspected Hirschsprung Disease

Halleran

Ahmad

Lehmkuhl

et al. 2020

Journal of Pediatric Surgery

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mentioning

confidence: 99%

Suction Rectal Biopsy is Accurate in Late Preterm Infants with Suspected Hirschsprung Disease

Halleran

Ahmad

Lehmkuhl

et al. 2020

Journal of Pediatric Surgery

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“…Eight VLBW infants were treated surgically in this study. nical or functional obstruction is common in VLBW infants 4,6) and often results in delayed initiation of enteral feeding and longer duration of TPN 7) . The main dilemma in MOP diagnosis is distinguishing it from simple delayed meconium passage of premature infants, leading to large differences in the reported incidences of MOP 8) .…”

Section: Clinical Characteristics and Risk Factors Of Vlbw Infants Wimentioning

confidence: 99%

Impact of Meconium Obstruction-Related Risk Factors on Surgical Intervention in Very Low Birth Weight Infants

et al. 2015

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Purpose: This study investigated the risks of development and surgical complications of meconium obstruction (MO) in very low birth weight (VLBW) infants. Methods: We performed a retrospective medical record review of VLBW infants admitted to the neonatal intensive care unit of Haeundae Paik hospital and diag nosed with MO of prematurity (MOP) between March 2010 and August 2013. Results: Of 267 VLBW infants admitted to the neonatal intensive care unit, 28 were diagnosed with MOP. Perinatal factors including maternal pregnancyinduced hyper tension and small for gestational age were associated with MOP development (P<0.05). Over twothirds of VLBW infants with MOP were successfully treated with a gas trografin enema. The remaining eight VLBW infants required surgery. Although small for gestational age was more frequent in the medical treatment group, specific risk factors associated with MOP development did not affect the need for surgical inter vention. Conclusion: MOP is common in VLBW infants, as most VLBW infants have risk factors for MOP. Identifying risk factors permits early diagnosis and initiation of appropriate medical treatment, reducing the necessity for surgery. However, the presence of specific risk factors does not increase risk of surgical complications.

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“…For instance, SIP was associated with intrauterine growth restriction and PDA with delayed meconium passage in VLBW infants. [21,22] Although this was a retrospective study, the cumulative dose of antenatal MgSO 4 , duration of antenatal MgSO 4 and level of magnesium were calculated and analyzed thoroughly. Factors associated with intestinal morbidities such as GA, SGA, and treated PDA were also reviewed.…”

Section: Discussionmentioning

confidence: 99%

Antenatal Magnesium Sulfate Reduced Intestinal Morbidities Requiring Surgery in Preterm Infants With Extremely Low Gestational Age: A Retrospective Cohort Study

Kim¹,

Kim²,

Shin³

et al. 2020

Preprint

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Background Antenatal magnesium sulfate is widely used as a tocolytic, for maternal seizures, and for seizure prophylaxis in preeclampsia. Recent studies have suggested that antenatal magnesium sulfate use is associated with favorable neurodevelopmental outcomes in preterm infants. However, there are concerns regarding the neonatal effects of antenatal magnesium sulfate, especially regarding gastrointestinal morbidities. This study aims to explore the effects of antenatal magnesium sulfate on intestinal morbidities requiring surgery in preterm infants.Methods This was a retrospective cohort study of 181 preterm infants who were born at less than 28 weeks of gestational age. Subjects were categorized as infants exposed to antenatal magnesium sulfate and those not exposed to antenatal magnesium sulfate.Results Antenatal magnesium sulfate was associated with a lower incidence of surgical conditions of the intestine (OR 0.393, 95% CI 0.170–0.905). Multivariate analysis showed that the duration of antenatal magnesium sulfate use was associated with surgical conditions of the intestine (adjusted OR 0.766, 95% CI 0.589–0.997). In the < 26 weeks of gestational age subgroup, use of antenatal magnesium sulfate was significantly associated with decreased intestinal morbidities requiring surgery (adjusted OR 0.234, 95% CI 0.060–0.922).Conclusion Antenatal magnesium sulfate use appears to have a protective effect on intestinal morbidities requiring surgery in preterm infants in a duration-dependent manner. Association of antenatal magnesium sulfate use and decreased intestinal morbidities requiring surgery was more distinct in preterm infants < 26 weeks of gestational age.

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Delayed Meconium Passage in Very Low Birth Weight Infants

Abstract: In very low birth weight infants delay in the passage of the first stool is common. Perforation in these patients may represent a fatal event, and procedures such as daily rectal enemas, which can prevent this complication, must be applied.

Cited by 21 publications

References 3 publications

Suction Rectal Biopsy is Accurate in Late Preterm Infants with Suspected Hirschsprung Disease

Suction Rectal Biopsy is Accurate in Late Preterm Infants with Suspected Hirschsprung Disease

Impact of Meconium Obstruction-Related Risk Factors on Surgical Intervention in Very Low Birth Weight Infants

Antenatal Magnesium Sulfate Reduced Intestinal Morbidities Requiring Surgery in Preterm Infants With Extremely Low Gestational Age: A Retrospective Cohort Study

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