Delayed manifestation of ultraviolet reaction in the guinea‐pig caused by anti‐inflammatory drugs

Gupta, Neelu; Levy, L

doi:10.1111/j.1476-5381.1973.tb08321.x

Cited by 28 publications

(12 citation statements)

References 5 publications

(3 reference statements)

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“…This implies an important role for histamine in mediating UV erythema, since the role of prostaglandins in mediating UV erythema is well established (3,(8)(9)(10)(11)(12). Several aspects of the data collected support this conclusion.…”

Section: Discussionsupporting

confidence: 71%

“…For example, significant elevations of arachidonic acid and its cyclooxygenase and lipoxygenase products are observed in dermal perfusates and in suction blisters raised on irradiated skin (3)(4)(5), and inhibition of cyclooxygenase-derived prostaglandins by indomethacin treatment blocks 50% of the erythema that develops during the first 24 h after UVB injury (3,(8)(9)(10)(11)(12). Studies of UV-irradiated keratinocytes.…”

Section: Introductionmentioning

confidence: 99%

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Enhanced prostaglandin synthesis after ultraviolet injury is mediated by endogenous histamine stimulation. A mechanism for irradiation erythema.

Pentland¹,

Mahoney²,

Jacobs³

et al. 1990

J. Clin. Invest.

116

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Acute ultraviolet light B (UVB) injury is associated with dermal mast cell histamine release. The possibility that histamine-stimulated prostaglandin (PG) synthesis could be a mechanism for irradiation erythema was therefore examined using human skin explants. Explants responded to UV irradiation (120 mJ/cm2) with a fivefold increase in synthesis of prostaglandins E2, F2. and 6-keto PGFIt. Incubating explants with the H1 antihistamines brompheniramine (50 MM) or pyrilamine (30 1AM) inhibited PG release from irradiated explants 63±4.9% (mean±SEM) 6 h after UV exposure. Antihistamines did not affect PG synthesis in control explants. Irradiation increased the histamine concentration in explant conditioned medium only 50% over basal values, suggesting that irradiation enhanced histamine responsiveness. Explants were therefore incubated with exogenous histamine. In irradiated explants, PG synthesis was stimulated threefold by 3 MM histamine. Unirradiated explants' PG synthesis was unaffected by histamine.Enhanced histamine sensitivity was also examined in epidermal cell cultures. In irradiated cultures, histamine sensitivity was again markedly potentiated: as little as 1 MM histamine stimulated significant PGE2 release and the response to 10-30 MAM histamine was increased six to eight times compared with that of unirradiated cultures. These studies demonstrate that endogenous histamine stimulates PG synthesis in human skin after UV injury by potentiation of histamine-induced prostaglandin release. Potentiated agonist responses induced by UV exposure may contribute to the effects of UVB irradiation injury and in particular to irradiation erythema. (J. Clin. Invest. 1990. 86:566-574.) Key words: ultraviolet light-skin -injury.

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Section: Discussionsupporting

confidence: 71%

Section: Introductionmentioning

confidence: 99%

Enhanced prostaglandin synthesis after ultraviolet injury is mediated by endogenous histamine stimulation. A mechanism for irradiation erythema.

Pentland¹,

Mahoney²,

Jacobs³

et al. 1990

J. Clin. Invest.

116

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“…Steroidal anti-inflammatories have been reported to be inactive in the guinea-pig model when administered either topically (Lambelin et al, 1970) or systemically (Winder et al, 1958;Gupta & Levy, 1973). However, applied topically some were as effective as nonsteroidal agents in suppressing erythema in the rat.…”

Section: Discussionmentioning

confidence: 99%

“…Non-steroidal anti-inflammatory drugs are effective against u.v.-induced erythema in guinea-pigs both systemically (Winder et al, 1958;Adams & Cobb, 1963;Gupta & Levy, 1973) and topically (Graeme, Peters, Maiorana & Cooper, 1975). We have shown a similar effect with these drugs in the rat.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Systemically and Topically Applied Drugs on Ultraviolet‐induced Erythema in the Rat

Law¹,

Lewis²

1977

British J Pharmacology

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Exposure of the skin of rats to u.v. light (>295 nm) for 30 s or longer elicited a delayed erythema response, the rate of onset increasing with the period of irradiation. The erythema was still present at 24 h and was replaced by scab formation in 48 hours. Both topically applied steroidal and non‐steroidal anti‐inflammatory drugs reduced the erythema formation when administered immediately after u.v. exposure. Propyl gallate, an antioxidant with sun screening properties in man, also possessed topical anti‐erythemic activity. Both steroidal and non‐steroidal anti‐inflammatory drugs, systemically administered 1 h before u.v. exposure, reduced the erythema. However, the steroidal compounds were less effective than the nonsteroids and reduced the intensity of erythema by less than 50%. Antagonists of 5‐hydroxytryptamine (5‐HT) reduced the erythema but several other drugs with different pharmacological activities were ineffective. Neither topical nor systemic treatments of any of the drugs examined suppressed the scab formation at 48 hours. These results and those using other selective blocking agents indicate that in the mediation of the erythema reaction prostaglandins may play a major role and 5‐HT perhaps a minor one but that H1 histamine receptors and α‐ and β‐adrenoceptors have no significant role.

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“…In vivo studies in humans have shown that mast cell degranulation occurs 4 h after skin irradiation (14,89), with histamine reaching maximal levels 9 to 15 h later and returning to basal levels after 24 h (8). Some authors (90)(91)(92) have shown that isolated mast cells can be stimulated to release histamine.…”

Section: Histaminementioning

confidence: 99%

Photochemistry and photobiology of actinic erythema: defensive and reparative cutaneous mechanisms

Tedesco¹,

Martínez²,

González³

1997

Braz J Med Biol Res

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Sunlight is part of our everyday life and most people accept it as beneficial to our health. With the advance of our knowledge in cutaneous photochemistry, photobiology and photomedicine over the past four decades, the terrestrial solar radiation has become a concern of dermatologists and is considered to be a major damaging environmental factor for our skin. Most photobiological effects (e.g., sunburn, suntanning, local and systemic immunosuppression, photoaging or dermatoheliosis, skin cancer and precancer, etc.) are attributed to ultraviolet radiation (UVR) and more particularly to UVB radiation (290-320 nm). UVA radiation (320-400 nm) also plays an important role in the induction of erythema by the photosensitized generation of reactive oxygen species (singlet oxygen OH)) that damage DNA and cellular membranes, and promote carcinogenesis and the changes associated with photoaging. Therefore, research efforts have been directed at a better photochemical and photobiological understanding of the so-called sunburn reaction, actinic or solar erythema. To survive the insults of actinic damage, the skin appears to have different intrinsic defensive mechanisms, among which antioxidants (enzymatic and non-enzymatic systems) play a pivotal role. In this paper, we will review the basic aspects of the action of UVR on the skin: a) photochemical reactions resulting from photon absorption by endogenous chromophores; b) the lipid peroxidation phenomenon, and c) intrinsic defensive cutaneous mechanisms (antioxidant systems). The last section will cover the inflammatory response including mediator release after cutaneous UVR exposure and adhesion molecule expression.Correspondence

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Delayed manifestation of ultraviolet reaction in the guinea‐pig caused by anti‐inflammatory drugs

Cited by 28 publications

References 5 publications

Enhanced prostaglandin synthesis after ultraviolet injury is mediated by endogenous histamine stimulation. A mechanism for irradiation erythema.

Enhanced prostaglandin synthesis after ultraviolet injury is mediated by endogenous histamine stimulation. A mechanism for irradiation erythema.

The Effect of Systemically and Topically Applied Drugs on Ultraviolet‐induced Erythema in the Rat

Photochemistry and photobiology of actinic erythema: defensive and reparative cutaneous mechanisms

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