Delayed loss of p75 neurotrophin receptor-immunoreactivity in the rat suprachiasmatic nucleus and intergeniculate leaflet after binocular enucleation

Moga, Margaret M.

doi:10.1016/s0304-3940(98)00658-2

Cited by 4 publications

(3 citation statements)

References 27 publications

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“…While some SCN rhythms are abolished by enucleation, such as the cycle of extracellular signal-regulated kinase (ERK) in a subset of SCN cells (271), most evidence suggests that the removal of the eyes induces plastic changes in the architecture of pacemaker neurons. Indeed, trophic factors (331) and adhesion molecules (516) change their SCN expression and distribution after enucleation, as well as astroglial distribution in the nuclei (267). Removal of the eyes also induces an increase in Fos expression in the SCN (35,294).…”

Section: Retinohypothalamic Interactions and Suprachiasmatic Nuclei Neurophysiologymentioning

confidence: 99%

Physiology of Circadian Entrainment

Golombék

Rosenstein

2010

Physiological Reviews

879

661

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Mammalian circadian rhythms are controlled by endogenous biological oscillators, including a master clock located in the hypothalamic suprachiasmatic nuclei (SCN). Since the period of this oscillation is of approximately 24 h, to keep synchrony with the environment, circadian rhythms need to be entrained daily by means of Zeitgeber ("time giver") signals, such as the light-dark cycle. Recent advances in the neurophysiology and molecular biology of circadian rhythmicity allow a better understanding of synchronization. In this review we cover several aspects of the mechanisms for photic entrainment of mammalian circadian rhythms, including retinal sensitivity to light by means of novel photopigments as well as circadian variations in the retina that contribute to the regulation of retinal physiology. Downstream from the retina, we examine retinohypothalamic communication through neurotransmitter (glutamate, aspartate, pituitary adenylate cyclase-activating polypeptide) interaction with SCN receptors and the resulting signal transduction pathways in suprachiasmatic neurons, as well as putative neuron-glia interactions. Finally, we describe and analyze clock gene expression and its importance in entrainment mechanisms, as well as circadian disorders or retinal diseases related to entrainment deficits, including experimental and clinical treatments.

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Section: Retinohypothalamic Interactions and Suprachiasmatic Nuclei Neurophysiologymentioning

confidence: 99%

Physiology of Circadian Entrainment

Golombék

Rosenstein

2010

Physiological Reviews

879

661

View full text Add to dashboard Cite

show abstract

“…Photic information necessary for entrainment is communicated to the circadian clock, the suprachiasmatic nucleus (SCN), via a direct projection from retinal ganglion cells that use glutamate as a primary transmitter (15,25,34,(37)(38)(39)44). In rats, a subpopulation of these axons express the low-affinity p75 neurotrophin receptor (p75NTR) (6,36,49). The terminals of these axons form a dense plexus which is confined to, and completely overlaps, the core region of the SCN (3,26,27,36).…”

Section: Introductionmentioning

confidence: 99%

“…In rats, a subpopulation of these axons express the low-affinity p75 neurotrophin receptor (p75NTR) (6,36,49). The terminals of these axons form a dense plexus which is confined to, and completely overlaps, the core region of the SCN (3,26,27,36). This region contains lightresponsive retinorecipient neurons that express N-methyl-D-aspartate (NMDA) and non-NMDA glutamate receptors (15,34) and are immunoreactive to vasoactive intestinal polypeptide (VIP) and calbindin-D28k (CaBP), both of which have been implicated in the mechanism of photic entrainment of circadian rhythms (2,8,29,(45)(46)(47)(48).…”

Section: Introductionmentioning

confidence: 99%