Delayed localization of A-type lamins to the rupture sites in Hutchinson–Gilford progeria syndrome
Yohei Kono,
Chan-Gi Pack,
Takehiko Ichikawa
et al.
Abstract:The nuclear lamina (NL) lines the inner nuclear membrane (INM) of the nuclear envelope (NE) to maintain nuclear structure in metazoan cells. The major NL components, the nuclear lamins contribute to the protection against NE rupture induced by mechanical stress. Lamin C (LC) but not lamin A (LA) is rapidly diffused from the nucleoplasm to sites of NE rupture induced by laser microirradiation in immortalized mouse embryonic fibroblasts (MEFs). However, the molecular mechanism for differentiating LA from LC with… Show more
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