Delayed Intra-articular Inflammatory Reaction Due to Poly-L-Lactide Bioabsorbable Interference Screw Used in Anterior Cruciate Ligament Reconstruction

Kwak, Ji Hoon; Sim, Jae Ang; Kim, Si Hwan; Lee, Kyoung Chan; Lee, Beom Koo

doi:10.1016/j.arthro.2007.11.012

Cited by 30 publications

(17 citation statements)

References 12 publications

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“…Bioabsorbable interference screws are known to be associated with delayed intraarticular inflammatory reaction 17 . In contrast, autogenous bone plugs are biocompatible.…”

Section: Discussionmentioning

confidence: 99%

Bone Tunnel Widening with Autogenous Bone Plugs Versus Bioabsorbable Interference Screws for Secondary Fixation in ACL Reconstruction

Kim

Bae

Song

et al. 2013

The Journal of Bone and Joint Surgery-American Volume

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The clinical results associated with bioabsorbable screws and bone plugs were not significantly different. Laxity evaluation demonstrated no significant differences between bioabsorbable screws and bone plugs. Compared with bioabsorbable interference screws, autogenous bone plugs reduced the complication rate and tibial tunnel widening without inducing instability. We believe that an autogenous bone plug for the tibial tunnel is a reasonable option in selected patients.

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“…Bioabsorbable interference screws are known to be associated with delayed intraarticular inflammatory reaction 17 . In contrast, autogenous bone plugs are biocompatible.…”

Section: Discussionmentioning

confidence: 99%

Bone Tunnel Widening with Autogenous Bone Plugs Versus Bioabsorbable Interference Screws for Secondary Fixation in ACL Reconstruction

Kim

Bae

Song

et al. 2013

The Journal of Bone and Joint Surgery-American Volume

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“…Nevertheless, despite the above findings, it has also been reported that PLLA and metallic screws are not significantly different in terms of biocompatibility and that no signs of inflammatory foreign body reaction were observed over 4 years of observation after PLLA implant placement. 18 Reported foreign body reactions to the PLLA implants include pretibial sterile abscess 9 and subcutaneous pretibial ganglion 23 formation, delayed intra-articular inflammatory reaction, 16 tibial and pretibial cyst formation, 17 aseptic synovitis, 21 foreign body gonitis, 22 and osteolytic foreign body reaction, 4,19 whereas reported foreign body reactions to PGA implants include osteolytic foreign body reaction, 1,2,5,12,24 aseptic synovitis, 13 and immune response. 20 Although mechanical complications such as breakage 10,11,14 and protrusion into the neighboring soft tissue 10 have been documented for the RIGIDFIX system, this type of biological response to its PLLA component has not been previously described in the literature.…”

Section: Discussionmentioning

confidence: 95%

Delayed Foreign Body Reaction Due to Bioabsorbable Pins Used for Femoral Fixation in Anterior Cruciate Ligament Reconstruction

et al. 2009

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“…According to two clinical follow-up studies, a clinically manifest foreign-body reaction to polylactide devices is very rare when the fixation devices are implanted intraosseously [50, 51]; but late foreign-body reactions have been reported in some cases when PLLA plates have been used on the bone [40, 52]. Intra-articular inflammatory reactions after the use of PLLA implants in reconstruction of the anterior cruciate ligament of the knee have been reported [53, 54]. …”

Section: Discussionmentioning

confidence: 99%

Tissue Restoration After Implantation of Polyglycolide, Polydioxanone, Polylevolactide, and Metallic Pins in Cortical Bone: An Experimental Study in Rabbits

et al. 2010

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We performed qualitative and histoquantitative investigations of tissue restoration after implanting polyglycolide (PGA), polydioxanone (PDS), polylevolactide (PLLA), and stainless steel pins in the intramedullary canal of rabbit femurs. The effect of bioabsorbable devices on healing of a cortical bone defect was also assessed. The cortical bone defect was created in the right femur of 80 rabbits. Bioabsorbable and metallic pins in 60 and two metallic pins alone were implanted in 20 intramedullary canals; 80 left femurs served as intact controls. Follow-up times were 3, 6, 12, 24, and 52 weeks. At all time points, collagenous connective tissue, including bone trabeculae, surrounded the implant at the tissue–implant interface, replacing hematopoiesis and fat of the intramedullary canal. The groups did not differ in the area and trabecular bone area fraction of the resulting callus. Residual fragments of PGA and PDS were observed at 24 weeks, and complete degradation occurred within 52 weeks. PGA, PDS, PLLA, and metallic implants induced a bony and fibrous walling-off response in the intramedullary cavity. No inflammation was observed. Complete tissue restoration did not occur within the follow-up, even after complete degradation of PGA and PDS, which had shorter degradation times than PLLA. The cortical bone healing effect was not different between bioabsorbable pins and metallic wires. Thus, these polymers had no specific osteostimulatory or osteoinhibitory properties compared to stainless steel. Within the follow-up period, there were no significant differences in biocompatibility between the implants and no adverse inflammatory foreign-body reactions.

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Delayed Intra-articular Inflammatory Reaction Due to Poly-L-Lactide Bioabsorbable Interference Screw Used in Anterior Cruciate Ligament Reconstruction

Cited by 30 publications

References 12 publications

Bone Tunnel Widening with Autogenous Bone Plugs Versus Bioabsorbable Interference Screws for Secondary Fixation in ACL Reconstruction

Bone Tunnel Widening with Autogenous Bone Plugs Versus Bioabsorbable Interference Screws for Secondary Fixation in ACL Reconstruction

Delayed Foreign Body Reaction Due to Bioabsorbable Pins Used for Femoral Fixation in Anterior Cruciate Ligament Reconstruction

Tissue Restoration After Implantation of Polyglycolide, Polydioxanone, Polylevolactide, and Metallic Pins in Cortical Bone: An Experimental Study in Rabbits

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