Delayed hypersensitivity testing for the prediction of postoperative complications

Abstract

One hundred and sixty-six patients undergoing elective major laparotomy were skin tested preoperatively with four common recall antigens in an attempt to correlate preoperative cell-mediated immune status with postoperative septic complications. Nineteen patients were anergic, 22 relatively anergic and the remaining 125 reacted to two or more of the antigens and were regarded as normally reactive. No significant differences in morbidity or mortality were found between patients who had depressed delayed cutaneous hypersensitivity reactions and those who reacted normally. We conclude that identification of those patients with depressed cell-mediated immunity preoperatively does not help in predicting postoperative problems.

Delayed Hypersensitivity Skin Testing of 150 Volunteers

“…This classification of patients as more or less anted to test the battery of g in a population with no expected defects in their cell-mediated immune mechanisms or in their inflammatory responses. In general, the antigens and antigen doses we used equaled those of other authors and our reactivity rates resemble those reported by them (1,5,12,17). This frequency of anergy is acceptable since we can hardly reach 100% reactivity with any battery of antigens in a large population.…”

“…The results of DH skin tests are often graded according to the number of positive reactions when several antigens are used (1,2,5,17). This classification of patients as more or less anted to test the battery of g in a population with no expected defects in their cell-mediated immune mechanisms or in their inflammatory responses.…”

“…The diameters of induration were read at 24 and 48 h. An induration of > 5 mm in diameter was considered as a positive result, because this is the most commonly accepted criterion for a positive reaction (1,3,4,5). intervals to get better prognostic information The test is technically simple and can be done than from a single measurement.…”

“…As a control, 0.1 ml of 0.9% NaCl solution was used. The diameters of induration were read at 24 and 48 h. An induration of > 5 mm in diameter was considered as a positive result, because this is the most commonly accepted criterion for a positive reaction (1,3,4,5). The tests were carried out in the afternoons by two persons (P.N.…”

Influence of Early Postoperative Enteral Nutrition versus Placebo on Cell-Mediated Immunity, As Measured with the Multitest® CMI

“…Some studies have confirmed that anergy is related to a high incidence of sepsis and death (7)(8)(9)(10)(11)(12)(14)(15)(16)(17), whereas other studies have failed to do so (18,19). Some studies have confirmed that anergy is related to a high incidence of sepsis and death (7)(8)(9)(10)(11)(12)(14)(15)(16)(17), whereas other studies have failed to do so (18,19).…”