Delayed hypersensitivity reaction to hyaluronic acid dermal filler post‐COVID‐19 viral infection

Shome, Debraj; Doshi, Komal; Vadera, Sapna; Kapoor, Rinky

doi:10.1111/jocd.14046

Cited by 27 publications

(38 citation statements)

References 3 publications

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“…Additionally, Shome et al described one case of swelling following COVID-19 11 months after having HA treatment which resolved with oral antiinflammatories. 16 This patient had prior HA treatments in the past without complications. Lastly, Cozzani et al detailed a case with multiple, erythematous nodules following prolonged sun exposure.…”

Section: Triggering or Predisposing Factorsmentioning

confidence: 92%

Delayed Complications following Dermal Filler for Tear Trough Augmentation: A Systematic Review

Trinh

McGuigan

Gupta³

2021

Facial Plast Surg

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Tear trough deformity is a popular target for the treatment with filler injections. The side effects are generally mild and transient. However, delayed complications may occur. We aim to perform a thorough systematic review of the published literature related to delayed complications after tear trough filler injections. A search of published literature was conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines in June 2021 and included PubMed, ScienceDirect, and Embase databases. The Medical Subject Headings (MeSH) terms used included the following terms: delayed complications, nodules, granulomas, swelling, discoloration, dermal filler, hyaluronic acid (HA), polyacrylamide, calcium hydroxyapatite (CaHA), poly-L-lactic acid (PLLA), eyelid, periorbital, periocular, and tear trough. Twenty-eight articles consisting of 52 individual cases were included in the final analysis. 98% (51/52) of patients were female and had an average age of 48.3 years. HA was the most reported product (71.2%, 37/52), followed by PLLA (4/52, 7.7%), and CaHA (4/52, 7.7%). The most common delayed complication with any dermal filler was swelling (42.3%, 22/52) followed by lumps or nodules (25.0%, 13/52). Xanthelasma-like reaction (17.3%, 9/52), migration (7.7%, 4/52), discoloration (3%, 3/52) also occurred. The average time of onset of any complication was 16.8 months with xanthelasma-like reaction appearing soonest (mean: 10 months) and discoloration appearing latest (mean: 52 months). Most swelling cases were caused by HA. Semi-permanent fillers such as PMMA and synthetic fillers such as PLLA were more likely to be associated with lumps and nodules than other complications. It is important that clinicians who perform tear trough augmentation with dermal fillers have a thorough understanding of the risks of the procedure to diagnose and manage them promptly as well as provide patients with accurate information regarding the potential adverse effects.

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Section: Triggering or Predisposing Factorsmentioning

confidence: 92%

Delayed Complications following Dermal Filler for Tear Trough Augmentation: A Systematic Review

Trinh

McGuigan

Gupta³

2021

Facial Plast Surg

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“…Likewise, Shome et al presented the case of a young woman who was rejuvenated using soft tissue fillers at multiple sites on her face. 31 She presented one month after SARS‐CoV‐2 infection with swelling around the periocular area. After treatment with anti‐inflammatory drugs, the swelling subsided.…”

Section: Resultsmentioning

confidence: 99%

“…Her symptoms resolved in six days without any medical treatment. Likewise, Shome et al presented the case of a young woman who was rejuvenated using soft tissue fillers at multiple sites on her face 31 . She presented one month after SARS‐CoV‐2 infection with swelling around the periocular area.…”

Section: Resultsmentioning

confidence: 99%

Late inflammatory reactions in patients with soft tissue fillers after SARS‐CoV‐2 infection and vaccination: A systematic review of the literature

Bachour

Bekkenk

Rustemeyer

et al. 2022

J of Cosmetic Dermatology

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Introduction Soft tissue fillers are used for cosmetic and reconstructive purposes, and soft tissue filler procedures are among the most common nonsurgical procedures in the USA. Although soft tissue filler procedures are relatively quick and safe, adverse events such as late inflammatory reactions have been reported with every filler product. Infections and vaccinations have been proposed as potential triggers for late inflammatory reactions (LIRs), and it is therefore not surprising that these adverse events have been reported after SARS‐CoV‐2 infection and vaccination. Therefore, this review aims to give a detailed overview of these cases. Materials and methods A literature search was undertaken on LIRs in patients with a history of soft tissue filler use after SARS‐CoV‐2 infection or vaccination. This systematic review was reported according to the PRISMA guidelines. We searched the electronic database PubMed from January 2020 to August 2021. Data on patient characteristics, filler characteristics, clinical findings, and treatment options were included. Results This review included 7 articles with a total of 19 patients with LIRs after SARS‐CoV‐2 infection or vaccination. Three patients with postinfection LIRs and 16 patients with postvaccination LIRs were reported. These LIRS mainly occurred in females who had HA injections for cosmetic purposes. Three patients with postinfection LIRs had symptoms of facial swelling and/or lip angioedema in a matter of weeks. Sixteen patients reported reactions after SARS‐CoV‐2 vaccination (13 following Moderna vaccination and 3 after Pfizer vaccination, after both the first and second doses) from 13 hours up to three weeks. These patients presented with similar clinical symptoms as patients with postinfection LIRs. All patients were treated in a conservative manner. Discussion This review shows a relationship between LIRs and SARS‐CoV‐2 infection and vaccination. In the case of vaccination, these adverse events have been reported only after Moderna and Pfizer vaccinations. The reported adverse events are generally minor and self‐limiting, and we encourage patients with soft tissue fillers to participate in vaccination programs.

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“…This reaction was observed in patients who received hyaluronic acid (HA) filler injections as facial "rejuvenation" treatment. It was characterized by the appearance of facial edema and erythema [11][12].…”

Section: Discussionmentioning

confidence: 99%

BCG Scar Local Skin Inflammation as a Novel Reaction Following mRNA COVID-19 Vaccines in Two International Healthcare Workers

Lopatynsky-Reyes¹,

Acosta-Lazo²,

Ulloa‐Gutiérrez³

et al. 2021

Cureus

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Delayed hypersensitivity reaction to hyaluronic acid dermal filler post‐COVID‐19 viral infection

Cited by 27 publications

References 3 publications

Delayed Complications following Dermal Filler for Tear Trough Augmentation: A Systematic Review

Delayed Complications following Dermal Filler for Tear Trough Augmentation: A Systematic Review

Late inflammatory reactions in patients with soft tissue fillers after SARS‐CoV‐2 infection and vaccination: A systematic review of the literature

BCG Scar Local Skin Inflammation as a Novel Reaction Following mRNA COVID-19 Vaccines in Two International Healthcare Workers

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