Delayed hypersensitivity granuloma formation around Schistosoma mansoni eggs in vitro. III. Granuloma formation and modulation in human Schistosomiasis mansoni.

Doughty, Barbara L.; Ottesen, Eric A.; Nash, Tony; Phillips, S M

doi:10.4049/jimmunol.133.2.993

Cited by 27 publications

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“…These results were in agreement with our findings. It might be explained by the fact that IgG antibody against Schistosoma might play an important role in the process of granuloma formation and liver fibrosis 19,37 . To prevent the development of hepatic fibrosis caused by schistosomiasis, surveillance should be strengthened particularly in those patients who are persistence of anti-Schistosoma IgG.…”

Section: Discussionmentioning

confidence: 99%

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Persistence of anti-Schistosoma IgG indicated a poor clinical outcome in patients with chronic schistosomiasis japonica

Xie

Li²,

Zhou

et al. 2023

Preprint

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Schistosomiasis is a chronic parasitic disease, which affects the quality of daily life of patients and imposes a huge burden on society. Hepatic fibrosis in response to continuous insult of eggs to the liver is a significant cause of morbidity and mortality. However, the mechanisms of hepatic fibrosis in schistosomiasis are largely undefined. The purpose of our study is to detect the indicator to hepatic fibrosis in schistosomiasis. A total of 488 patients with chronic schistosomiasis japonica were enrolled in our study. The patients were divided into two groups according to liver ultrasound examination, which could indicate liver fibrosis of schistosomiasis with unique reticular changes. Logistic regression analysis showed that globulin, albumin/globulin, GGT levels and anti-Schistosoma IgG were independently associated with liver fibrosis in patients with schistosomiasis and IgG was the largest association of liver fibrosis (OR = 2.039, 95% CI = 1.293-3.213). We further compared IgG+ patients with IgG-patients. IgG+ patients (ALT 25 U/L, GGT 31 U/L) slightly higher than IgG-patients (ALT 22 U/L, GGT 26 U/L) in ALT and GGT. However, the fibrosis of liver in IgG+ patients (Grade Ⅱ(19.7%), Grade Ⅲ(7.3%)) were more severe than that in IgG-patients(Grade Ⅱ(12.5%), Grade Ⅲ(2.9%)) according to the grade of liver ultrasonography. Our results showed anti-Schistosoma IgG was independently associated with liver fibrosis in patients with chronic schistosomiasis japonica and patients with persistent anti-Schistosoma IgG might have more liver fibrosis than negative patients despite no obvious clinical signs or symptoms.

show abstract

Section: Discussionmentioning

confidence: 99%

“…There are several limitations that need to be addressed in our study. First, liver fibrosis was evaluated by colour ultrasound which was in accordance with the World Health Organization diagnostic criteria for S. japonicum, lacking of liver biopsies results 19,37 . Second, the reasons affecting IgG antibody changes have not been found.…”

Section: Discussionmentioning

confidence: 99%

Persistence of anti-Schistosoma IgG indicated a poor clinical outcome in patients with chronic schistosomiasis japonica

Xie

Li²,

Zhou

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…These results were in agreement with our findings. It might be explained by the fact that IgG antibody against Schistosoma might play an important role in the process of granuloma formation and liver fibrosis 24 , 39 . To prevent the development of hepatic fibrosis caused by schistosomiasis, surveillance should be strengthened particularly in those patients who are persistence of anti- Schistosoma IgG.…”

Section: Discussionmentioning

confidence: 99%

“…There are several limitations that need to be addressed in our study. First, liver fibrosis was evaluated by colour ultrasound which was in accordance with the World Health Organization diagnostic criteria for S. japonicum , lacking of liver biopsies results 24 , 39 . Second, the reasons affecting IgG antibody changes have not been found.…”

Section: Discussionmentioning

confidence: 99%

IgG persistence showed weak clinical aspects in chronic schistosomiasis patients

Xie

Zhou

et al. 2023

Sci Rep

View full text Add to dashboard Cite

Schistosomiasis is a chronic parasitic disease, which affects the quality of daily life of patients and imposes a huge burden on society. Hepatic fibrosis in response to continuous insult of eggs to the liver is a significant cause of morbidity and mortality. However, the mechanisms of hepatic fibrosis in schistosomiasis are largely undefined. The purpose of our study is to detect the indicator to hepatic fibrosis in schistosomiasis. A total of 488 patients with chronic schistosomiasis japonica were enrolled in our study. The patients were divided into two groups according to liver ultrasound examination, which could indicate liver fibrosis of schistosomiasis with unique reticular changes. Logistic regression analysis showed that globulin, albumin/globulin, GGT levels and anti-Schistosoma IgG were independently associated with liver fibrosis in patients with schistosomiasis and IgG was the largest association of liver fibrosis (OR 2.039, 95% CI 1.293–3.213). We further compared IgG+ patients with IgG− patients. IgG+ patients (ALT 25 U/L, GGT 31 U/L) slightly higher than IgG− patients (ALT 22 U/L, GGT 26 U/L) in ALT and GGT. However, the fibrosis of liver in IgG+ patients (Grade II(19.7%), Grade III(7.3%)) were more severe than that in IgG− patients(Grade II(12.5%), Grade III(2.9%)) according to the grade of liver ultrasonography. Our results showed anti-Schistosoma IgG was independently associated with liver fibrosis in patients with chronic schistosomiasis japonica and patients with persistent anti-Schistosoma IgG might have more liver fibrosis than negative patients despite no obvious clinical signs or symptoms.

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Nitric Oxide-Mediated Immune Complex-Induced Prostaglandin E2 Production by Peripheral Blood Mononuclear Cells of Humans Infected with Schistosoma mansoni

Neves

Rezende

Góes

1999

Cellular Immunology

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Granuloma reaction around Schistosoma mansoni eggs is the prominent lesion in human schistosomiasis. Studies have suggested the involvement of a series of suppressive mechanisms in the control of this reaction. Using an in vitro model of granuloma formation, we have shown that immune complexes (IC) isolated from sera of chronic intestinal schistosomiasis patients were able to reduce granulomatous reaction developed against soluble egg antigen-conjugated polyacrylamide beads. In this system, the role of the l-arginine-nitric oxide (NO) pathway in the formation of prostaglandin E(2) (PGE(2)) by human peripheral blood mononuclear cells (PBMC) of patients infected with schistosomiasis was investigated using IC. Preincubation of PBMC with IC produced a significant increase of both nitrite and PGE(2) levels in the cell supernatant. This effect was inhibited by coincubation of cells with Nomega-nitro-l-arginine methyl ester (L-NAME), a NO synthase inhibitor, showing that the release of PGE(2) subsequent to IC stimulation was driven by NO. The inhibitory effect of L-NAME on PGE(2) release by IC-treated PBMC was reversed by sodium nitroprusside, a known NO donor. Our results indicate that NO could be an important second signal for the stimulation of PGE(2) production induced by IC in PBMC from human schistosomiasis patients.

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Delayed hypersensitivity granuloma formation around Schistosoma mansoni eggs in vitro. III. Granuloma formation and modulation in human Schistosomiasis mansoni.

Cited by 27 publications

References 0 publications

Persistence of anti-Schistosoma IgG indicated a poor clinical outcome in patients with chronic schistosomiasis japonica

Persistence of anti-Schistosoma IgG indicated a poor clinical outcome in patients with chronic schistosomiasis japonica

IgG persistence showed weak clinical aspects in chronic schistosomiasis patients

Nitric Oxide-Mediated Immune Complex-Induced Prostaglandin E2 Production by Peripheral Blood Mononuclear Cells of Humans Infected with Schistosoma mansoni

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