Delayed Haemolytic Transfusion Reactions due to Anti‐C

Abstract

In 5 patients of phenotype ccDEe or ccDEE, the transfusion of 2--14 U of C-positive blood was folloued 5--9 days later by haemoglobinuria lasting 2--4 days. Anti-C was the only antibody present in all 5 cases but was always of low titre; with CC cells the maximum titre recorded with the indirect antiglobulin test was 8 and with the agglutination of enzyme-treated cells, 128. The discordance between the weakness of the antibody in vivo and the amount of haemoglobin released intravascularly is surprising but may be related to the type of IgG molecule of which anti-C is composed.

Complex delayed blood transfusion reaction: A case report

“…Continuous mild fever should be treated seriously by the physician. [ 7 ] In such cases, re-transfusion should be halted, the cause identified, and effective transfusion administered promptly.…”