1971
DOI: 10.1016/s0140-6736(71)92363-4
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Delayed Hæmolytic Transfusion Reaction With Renal Failure

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1978
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Cited by 25 publications
(5 citation statements)
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“…Delayed haemolytic transfusion reactions presenting with haemoglobinuria are of rare occurrence, and appear to be related to the rate of haemolysis or the specificity of the antibody rather than to the involvement of complement [9], In 10 reported cases of haemoglobinuria developing between 6 and 13 days after the transfusion of 2-10 U of blood, antibodies with the following speci ficities were present in the patient's serum: anti-U [8,14], anti-c [15], anti-c +-M [1], anti-Jka [13], anti-Jkb [4,7], anti-HI, -Jkb, -S, -Fya [3], anti-E, -K, -S, -Fya [10] and anti-C, -E, -Jkb [6]. A similar range of anti body specificities, but excluding anti-U, has been reported in cases of delayed haemolytic transfusion reactions presenting with jaun dice or anaemia [1, 2, 11 -13, 16].…”
mentioning
confidence: 99%
“…Delayed haemolytic transfusion reactions presenting with haemoglobinuria are of rare occurrence, and appear to be related to the rate of haemolysis or the specificity of the antibody rather than to the involvement of complement [9], In 10 reported cases of haemoglobinuria developing between 6 and 13 days after the transfusion of 2-10 U of blood, antibodies with the following speci ficities were present in the patient's serum: anti-U [8,14], anti-c [15], anti-c +-M [1], anti-Jka [13], anti-Jkb [4,7], anti-HI, -Jkb, -S, -Fya [3], anti-E, -K, -S, -Fya [10] and anti-C, -E, -Jkb [6]. A similar range of anti body specificities, but excluding anti-U, has been reported in cases of delayed haemolytic transfusion reactions presenting with jaun dice or anaemia [1, 2, 11 -13, 16].…”
mentioning
confidence: 99%
“…Anti‐U is a clinically significant antibody; it is known to cause either acute and delayed HTRs in all case reports described in the literature to date, and therefore must be treated with caution. Case reports of anti‐U in the literature include descriptions of one case of a fatal acute HTR and several examples of delayed HTRs . with no published cases describing outcomes of transfusion in patients with anti‐U with no adverse side effects.…”
Section: Discussionmentioning
confidence: 99%
“…Anti‐U is an immunoglobulin G antibody, formed as a consequence of blood transfusion or pregnancy. Anti‐U is clinically significant and is known to cause acute and delayed hemolytic transfusion reactions (HTRs) and hemolytic disease of the fetus and newborn (HDFN) . Every attempt should must be made to provide U– units to patients with anti‐U.…”
mentioning
confidence: 99%
“…Although the literature contains many cases of antibody-mediated delayed hemolytic transfusion reaction (DHTR) in which subsequent retesting of pretransfusion specimens showed no antibody by "usual" or "standard" techniques, no information about what serum: cell ratio was employed is provided.4, 8-11, [14][15][16][17]20,21,[24][25][26][27]32 In order to minimize errors in in vitro tests for detection of clinically significant antigens and antibodies, it is important to I) standardize pretransfusion test methodology by adopting an optimum serum:cell ratio, 2) test the drop delivery volume of dropper pipettes used in antibody detection! compatibility tests as part of the quality control of equipment, 3) promote standardization of the concentration of commercial reagent red blood cells and the drop delivery volume of their vial droppers, and 4) save pretransfusion samples for 14 days after the patient's transfusion.…”
Section: Discussionmentioning
confidence: 99%