Delayed Graft Function: Risk Factors and the Effects of Early Function and Graft Survival

Miglinas, Marius; Supranaviciene, L.; Mateikaite, K.; Skebas, Karolis; Kubilienė, Asta

doi:10.1016/j.transproceed.2013.03.014

Cited by 18 publications

(25 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…17,42,49 It is not surprising that patients with kDGF had significantly worse kidney graft function at three and twelve months after transplant, which agrees with studies results performed on KTA patients. 12,17,49 There was no observed difference in the incidence of biopsy-proven acute graft rejection, potentially attributed to the immunoprotective effect of the liver allograft procured from the same donor, which is not the case among KTA recipients who experience higher rates of acute graft rejection. 17,22,49,50 …”

Section: Discussionsupporting

confidence: 83%

“…12,17,49 There was no observed difference in the incidence of biopsy-proven acute graft rejection, potentially attributed to the immunoprotective effect of the liver allograft procured from the same donor, which is not the case among KTA recipients who experience higher rates of acute graft rejection. 17,22,49,50 The decline in short-term graft function among recipients with kDGF appeared to translate in the long-term graft and patient survival. Overall patient survival and death-censored allograft survival among the whole cohort of recipients of SLKT were comparable to those reported in the literature.…”

Section: Discussionmentioning

confidence: 91%

“…Graft survival among SLKT recipients with kDGF may not be comparable to that among KTA patients with kDGF because of the differences in patient physiology and operative exposure. 12,44,49,53 Studies comparing outcomes of SLKT to KTA reported inferior kidney graft survival rates among SLKT recipients. 52,54 Overall patient survival rates were worse among kDGF patients in the first few years post-transplant; however, the difference tended to decline and became less pronounced later.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Factors predicting kidney delayed graft function among recipients of simultaneous liver‐kidney transplantation: A single‐center experience

Korayem

Agopian

Lunsford

et al. 2019

Clinical Transplantation

View full text Add to dashboard Cite

Background: Kidney delayed graft function (kDGF) remains a challenging problem following simultaneous liver and kidney transplantation (SLKT) with a reported incidence up to 40%. Given the scarcity of renal allografts, it is crucial to minimize the development of kDGF among SLKT recipients to improve patient and graft outcomes. We sought to assess the role of preoperative recipient and donor/graft factors on developing kDGF among recipients of SLKT. Methods: A retrospective review of 194 patients who received SLKT in the period from January 2004 to March 2017 in a single center was performed to assess the effect of preoperative factors on the development of kDGF. Results: Kidney delayed graft function was observed in 95 patients (49%). Multivariate analysis revealed that donor history of hypertension, cold static preservation of kidney grafts [versus using hypothermic pulsatile machine perfusion (HPMP)], donor final creatinine, physiologic MELD, and duration of delay of kidney transplantation after liver transplantation were significant independent predictors for kDGF. kDGF is associated with worse graft function and patient and graft survival. Conclusions: Kidney delayed graft function has detrimental effects on graft function and graft survival. Understanding the risks and combining careful perioperative patient management, proper recipient selection and donor matching, and graft preservation using HPMP would decrease kDGF among SLKT recipients.

show abstract

Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Factors predicting kidney delayed graft function among recipients of simultaneous liver‐kidney transplantation: A single‐center experience

Korayem

Agopian

Lunsford

et al. 2019

Clinical Transplantation

View full text Add to dashboard Cite

show abstract

“…As expected, and already demonstrated in previous studies [6], DGF significantly prolonged initial posttransplant hospitalization (median 28 days in DGF vs. 12 days in IGF group) in our cohort. However, hospitalizations were much shorter in our patients, both in the IGF and DGF group probably because of our large centre size and extensive experience, with as short hospitalizations as possible.…”

Section: Discussionsupporting

confidence: 92%

“…Brain death consequences, hemodynamic instability, as well as acute injury induced during kidney recovering and preservation may have significant consequences. Recipient factors known to affect posttransplant outcome include age, cardiac status, dialysis vintage and hypotension [6]. Faced with aging dialysis population, we are also faced with aging population of potential renal transplant recipients with numerous comorbidities.…”

Section: Introductionmentioning

confidence: 99%

Expression of BMP-2 in Vascular Endothelial Cells of Recipient May Predict Delayed Graft Function After Renal Transplantation

Bašić‐Jukić

Gulin

Hudolin

et al. 2016

Kidney Blood Press Res

View full text Add to dashboard Cite

Background/Aims: Delayed graft function (DGF) is associated with adverse outcomes after renal transplantation. Bone morphogenetic protein-2 (BMP-2) is involved in both endothelial function and immunological events. We compared expression of BMP-2 in epigastric artery of renal transplant recipients with immediate graft function (IGF) and DGF. Methods: 79 patients were included in this prospective study. Patients were divided in IGF group (64 patients) and DGF group (15 patients). BMP-2 expression in intima media (BMP2m) and endothelium (BMP2e) of epigastric artery was assessed by immunohistochemistry. Results: Lower intensity of BMP2e staining was recorded in DGF compared to IGF. In DGF patients, 93% had no expression of BMP2e and 7% had 1^st grade expression, compared to 45% and 41% in IGF group, respectively (P=0.001) (P<0.001 for no expression and P = 0.015 for 1^st grade expression). Patients who had BMP2e staining positive had lower odds for DGF (OR 0.059 [0.007, 0.477]) and this remained significant even after adjustment for donor and recipient variables, cold ischemia time, and immunological matching (OR 0.038 [0.003, 0.492]). Conclusions: Our results demonstrate that BMP-2 expression in endothelial cells of epigastric arteries may predict development of DGF.

show abstract

Assessment of delayed graft function using susceptibility-weighted imaging in the early period after kidney transplantation: a feasibility study

Sun

Chen

et al. 2018

Abdom Radiol

View full text Add to dashboard Cite

show abstract

Delayed Graft Function: Risk Factors and the Effects of Early Function and Graft Survival

Cited by 18 publications

References 22 publications

Factors predicting kidney delayed graft function among recipients of simultaneous liver‐kidney transplantation: A single‐center experience

Factors predicting kidney delayed graft function among recipients of simultaneous liver‐kidney transplantation: A single‐center experience

Expression of BMP-2 in Vascular Endothelial Cells of Recipient May Predict Delayed Graft Function After Renal Transplantation

Assessment of delayed graft function using susceptibility-weighted imaging in the early period after kidney transplantation: a feasibility study

Contact Info

Product

Resources

About