Delayed Gastric Emptying Scintigraphy in Cystic Fibrosis Patients Before and After Lung Transplantation

Bodet-Milin, Caroline; Querellou, Solène; Oudoux, A.; Haloun, A.; Horeau-Llanglard, Delphine; Carlier, Thomas; Bizais, Y.; Couturier, O.

doi:10.1016/j.healun.2006.04.013

Cited by 56 publications

(55 citation statements)

References 22 publications

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“…In contrast, we were not able to see effects of pancreatic enzyme supplementation on GLP-1 in our study. Reports on gastric emptying rate in CF are also conflicting and both increased and delayed gastric emptying have been suggested in this group of patients [28][29][30][31][32]. Together with gastric dysmobility and malnutrition often observed in these patients it is tempting to speculate on the impact of incretins in this group of patients.…”

Section: Discussionmentioning

confidence: 96%

Reduced levels of active GLP-1 in patients with cystic fibrosis with and without diabetes mellitus

Hillman

Eriksson

Mared

et al. 2012

Journal of Cystic Fibrosis

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Glucagon like peptide 1 (GLP-1) is an incretin hormone released as a bioactive peptide from intestinal L-cells in response to eating. It acts on target cells and exerts several functions as stimulating insulin and inhibiting glucagon. It is quickly deactivated by the serine protease dipeptidyl peptidase IV (DPP-IV) as an important regulatory mechanism. GLP-1 analogues are used as antidiabetic drugs in patients with type 2 diabetes. We served patients with cystic fibrosis (CF, n=29), cystic fibrosis related diabetes (CFRD, n=19) and healthy controls (n=18) a standardized breakfast (23 g protein, 25 g fat and 76 g carbohydrates) after an overnight fasting. Blood samples were collected before meal as well as 15, 30, 45 and 60 min after the meal in tubes prefilled with a DPP-IV inhibitor. The aim of the study was to compare levels of GLP-1 in patients with CF, CFRD and in healthy controls. We found that active GLP-1 was significantly decreased in patients with CF and CFRD compared to in healthy controls (p<0.01). However, levels in patients with CFRD tended to be lower but were not significantly lower than in patients with CF without diabetes (p=0.06). Total GLP-1 did not differ between the groups, which points to that the inactive form of GLP-1 is more pronounced in CF patients. The endogenous insulin production (measured by C-peptide) was significantly lower in patients with CFRD as expected. However, levels in non-diabetic CF patients did not differ from the controls. We suggest that the decreased levels of GLP-1 could affect the progression toward CFRD and that more studies need to be performed in order to evaluate a possible treatment with GLP-1 analogues in CF-patients.

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Section: Discussionmentioning

confidence: 96%

Reduced levels of active GLP-1 in patients with cystic fibrosis with and without diabetes mellitus

Hillman

Eriksson

Mared

et al. 2012

Journal of Cystic Fibrosis

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“…It is well-known that a high fat meal can delay gastric emptying, leading to a shallower rise in plasma glucose after the TM compared to the OGTT [13]. This could be important since severely affected CF individuals have a higher rate of delayed gastric emptying [14,15] while the opposite has been reported in less affected patients [16]. Alternatively, it could be due to differential incretin secretion between the 2 conditions.…”

Section: Discussionmentioning

confidence: 99%

Dichotomy between postprandial glucose and lipid profiles in adults with cystic fibrosis: A pilot study

Hammana

Coderre

Potvin

et al. 2009

Journal of Cystic Fibrosis

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“…26 Gastroparesis, seen in 20 of 30 pre-transplant patients in another study, may be a significant contributing factor for reflux in patients with CF. 27 Most adults with CF, therefore, have GORD, and perhaps a broader disorder of foregut motility.…”

Section: Cystic Fibrosismentioning

confidence: 99%

Gastro-oesophageal reflux and aspiration in patients with advanced lung disease

Sweet

Patti

Hoopes

et al. 2009

Thorax

122

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Delayed Gastric Emptying Scintigraphy in Cystic Fibrosis Patients Before and After Lung Transplantation

Cited by 56 publications

References 22 publications

Reduced levels of active GLP-1 in patients with cystic fibrosis with and without diabetes mellitus

Reduced levels of active GLP-1 in patients with cystic fibrosis with and without diabetes mellitus

Dichotomy between postprandial glucose and lipid profiles in adults with cystic fibrosis: A pilot study

Gastro-oesophageal reflux and aspiration in patients with advanced lung disease

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