Delayed gastric emptying in infants with gastroesophageal reflux

Hillemeier, A. Craig; Lange, Robert; McCallum, Richard W.; Seashore, John H.; Gryboski, Joyce D.

doi:10.1016/s0022-3476(81)80633-6

Cited by 169 publications

(55 citation statements)

References 16 publications

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“…The determination of liquid GET ½ in age specific group during infancy was done in our study when compared to the previous studies where predominantly children age groups of infancy were compared with older children. [2][3][4][5][6][7][8] The radiopharmaceutical used in this study gave less radiation to the infants as opposed to the radiopharmaceutical used earlier. 4 There was significant difference found for liquid GET ½ in 29 days to 3 months and 10 months to 1 year groups; whereas Argon et al did not find significant difference in GET ½ between GER positive and GER negative groups.…”

Section: Discussionmentioning

confidence: 99%

“…8 There was statistically significant difference for liquid GET ½ found between the mild GER and severe GER in our study, that supports the finding of association delayed gastric emptying and presence of severe degree of gastroesophageal reflux. 7,8,16 The association of all age groups with delayed emptying could not be established due to strict exclusion criteria applied for selection of reference range. The delayed liquid GET ½ was studied whereas the early emptying was not taken into consideration, as it may not influence the GER.…”

Section: Discussionmentioning

confidence: 99%

“…These studies have included age group varying from infancy till early childhood and age-related dependence was reported. [3][4][5][6][7][8] The GET ½ or…”

Section: Introductionmentioning

confidence: 99%

“…7 The gastric emptying and GER studies have been combined using scintigraphy methods earlier to serve the purpose of obtaining additional information from the same study. 3,[9][10][11] The gastric motility studies with drugs also have been performed to assess the response to medical management.…”

Section: Introductionmentioning

confidence: 99%

“…12 The relationship between the GER and GET has been studied in the wide age group (infancy to pre-school) by using various protocols, however data specific to infancy is lacking. 3,7,8,[13][14][15][16][17] It has been noticed that, the establishment of normal range for GET is problematic due to lack of standardization of study technique and the test meal especially in infant group. 3 There is lack of reference data for gastric emptying in infants in the existing guidelines.…”

Section: Introductionmentioning

confidence: 99%

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Liquid gastric emptying time 1/2 in infants: establishing reference range and it's co-relation with presence of gastro-esophageal reflux

et al. 2016

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INTRODUCTIONGastric emptying time ½ (GET ½) is considered as the half time taken for chyme to pass into the duodenum. Gastric emptying depends upon numerous factors, both endogenous and exogenous. Nerve and hormones along with volume of meal, pH, particle size, composition and viscosity play part in gastric emptying.1 In infant population, gastric emptying also depends upon the maturity at the time of birth. The gastric emptying pattern is different in infants fed with breast milk and formula feeds and so gastric emptying has to be diligently worked out. 2There have been many studies performed using different radiopharmaceutical meals such as In-111 micro colloid in fixed quantity of milk, Tc-99m sulfur colloid in dextrose, Tc-99m labeled to chicken liver with establishment of various reference standards for liquid and solid emptying times. These studies have included age group varying from infancy till early childhood and age-related dependence was reported.3-8 The GET ½ or ABSTRACT Background: Gastric emptying time ½ (GET ½) is considered as the half time taken for chyme to pass into the duodenum. Gastric emptying depends upon numerous factors, both endogenous and exogenous. Nerve and hormones along with volume of meal, pH, particle size, composition and viscosity play part in gastric emptying. Aim of the study was to determine liquid gastric emptying Time ½ in infants and to evaluate impact of positive GER on Gastric Emptying Time. Methods: Total 149 full term babies from 29th day to 1 year of age; underwent Tc-99m labeled with Sulfur colloid GER scintigraphy using age specific formula. Babies with gastro-intestinal anomalies, lactose intolerance and low birth weight babies were excluded. The reference range of GET ½ was estimated from GER negative group and the same was compared with GER positive group. Results: Out of 149 babies 96 (64%) babies were GER positive and 53 (36%) were negative for GER. The liquid GET ½ values generated for 29 th day-3 months, 4-6 months, 7-9 months and 10 months -1year were 62.67 (12.42), 69.84 (13), 63.5 (9.7) and 53.2 (10) minutes respectively. The liquid GET½ was found to be delayed in severe GER positive group. Conclusions: The reference range for liquid GET½ was estimated from GER negative group utilizing the exclusion criteria thereby avoiding radiation exposure to normal controls. With increasing severity of GER there was consequent prolongation of liquid GET½.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…These studies have included age group varying from infancy till early childhood and age-related dependence was reported. [3][4][5][6][7][8] The GET ½ or…”

Section: Introductionmentioning

confidence: 99%