Delayed Fever and Neurological Outcome after Cardiac Arrest: A Retrospective Clinical Study

Picetti, Edoardo; Antonini, Marta Velia; Bartolini, Yerma; DeAngelis, Antonino; Delaj, Laura; Florindo, Irene; Villani, Fabio; Caspani, Maria Luisa

doi:10.1007/s12028-016-0251-0

Cited by 17 publications

(12 citation statements)

References 36 publications

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“…induction of hypothermia at 32À36 C) is also called rebound hyperthermia and is associated with worse outcomes, in particular with high temperatures. 211,212 Whether fever contributes to poor neurological outcome or is just a marker of severe brain injury remains unknown. To date, no randomised trial has compared controlled normothermia (i.e.…”

Section: Treatment Of Fevermentioning

confidence: 99%

European Resuscitation Council and European Society of Intensive Care Medicine Guidelines 2021: Post-resuscitation care

et al. 2021

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The European Resuscitation Council (ERC) and the European Society of Intensive Care Medicine (ESICM) have collaborated to produce these postresuscitation care guidelines for adults, which are based on the 2020 International Consensus on Cardiopulmonary Resuscitation Science with Treatment Recommendations. The topics covered include the post-cardiac arrest syndrome, diagnosis of cause of cardiac arrest, control of oxygenation and ventilation, coronary reperfusion, haemodynamic monitoring and management, control of seizures, temperature control, general intensive care management, prognostication, long-term outcome, rehabilitation, and organ donation.

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Section: Treatment Of Fevermentioning

confidence: 99%

European Resuscitation Council and European Society of Intensive Care Medicine Guidelines 2021: Post-resuscitation care

et al. 2021

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“…Fever following TTM (i.e. induction of hypothermia at 32-36 °C) is also called rebound hyperthermia and is associated with worse outcomes, in particular with high temperatures [211,212]. Whether fever contributes to poor neurological outcome or is just a marker of severe brain injury remains unknown.…”

Section: Treatment Of Fevermentioning

confidence: 99%

European Resuscitation Council and European Society of Intensive Care Medicine 2015 guidelines for post-resuscitation care

et al. 2015

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The European Resuscitation Council and the European Society of Intensive Care Medicine have collaborated to produce these post-resuscitation care guidelines, which are based on the 2015 International Consensus on Cardiopulmonary Resuscitation Science with Treatment Recommendations. Recent changes in post-resuscitation care include: (a) greater emphasis on the need for urgent coronary catheterisation and percutaneous coronary intervention following out-of-hospital cardiac arrest of likely cardiac cause; (b) targeted temperature management remains important but there is now an option to target a temperature of 36 °C instead of the previously recommended 32-34 °C; (c) prognostication is now undertaken using a multimodal strategy and there is emphasis on allowing sufficient time for neurological recovery and to enable sedatives to be cleared; (d) increased emphasis on rehabilitation after survival from a cardiac arrest.

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“…Recent small and highly biased studies have suggested that a slow and controlled rewarming rate is feasible and may be associated with better long-term neurological outcomes [30,31]. Finally, because many studies have suggested a detrimental effect of post-TTM fever on outcome [32,33], careful control of body temperature for at least 48 h following the end of rewarming is mandatory; this strategy could be titrated to patient condition (i.e., shorter if immediate awakening or prolonged in case of signs of moderate to severe cerebral insult).…”

Section: Duration Of the Rewarming Phasementioning

confidence: 99%

High Quality Targeted Temperature Management (TTM) After Cardiac Arrest

2020

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Targeted temperature management (TTM) is a complex intervention used with the aim of minimizing post-anoxic injury and improving neurological outcome after cardiac arrest. There is large variability in the devices used to achieve cooling and in protocols (e.g., for induction, target temperature, maintenance, rewarming, sedation, management of post-TTM fever). This variability can explain the limited benefits of TTM that have sometimes been reported. We therefore propose the concept of "high-quality TTM" as a way to increase the effectiveness of TTM and standardize its use in future interventional studies.

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Delayed Fever and Neurological Outcome after Cardiac Arrest: A Retrospective Clinical Study

Abstract: Fever is frequent after CA, and Tmax in ICU is associated with worsened neurological outcome. This association becomes stronger as the timing of Tmax extends further from the CA.

Cited by 17 publications

References 36 publications

European Resuscitation Council and European Society of Intensive Care Medicine Guidelines 2021: Post-resuscitation care

European Resuscitation Council and European Society of Intensive Care Medicine Guidelines 2021: Post-resuscitation care

European Resuscitation Council and European Society of Intensive Care Medicine 2015 guidelines for post-resuscitation care

High Quality Targeted Temperature Management (TTM) After Cardiac Arrest

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