Delayed emergence of a parkinsonian disorder or dementia in 81% of older men initially diagnosed with idiopathic rapid eye movement sleep behavior disorder: a 16-year update on a previously reported series

Schenck, Carlos H.; Boeve, Bradley F.; Mahowald, Mark W.

doi:10.1016/j.sleep.2012.10.009

Cited by 682 publications

(489 citation statements)

References 41 publications

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“…With long term follow-up, more than 80% of individuals with idiopathic RBD developed either Parkinson's disease (PD), dementia with Lewy bodies (DLB) or multiple system atrophy (MSA) ,Schenck, et al, 2013. It was suggested that RBD may define a subtype of PD patients (Fereshtehnejad, et al, 2015,Gagnon, et al, 2004 with cognitive decline (Gagnon, et al, 2009,Vendette, et al, 2007, dementia (Anang, et al, 2014), hallucinations (Sixel-Doring, et al, 2011) and autonomic dysfunction (Postuma, et al, 2008), as compared to PD patients without RBD.…”

Section: Introductionmentioning

confidence: 99%

The dementia-associated APOE ε4 allele is not associated with rapid eye movement sleep behavior disorder

Gan‐Or

Montplaisir

Ross

et al. 2017

Neurobiology of Aging

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The dementia-associated APOE ε4 allele is not associated with REM sleep behavior disorder, Neurobiology of Aging (2016Aging ( ), doi: 10.1016Aging ( /j.neurobiolaging.2016 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. M A N U S C R I P T A C C E P T E D ACCEPTED MANUSCRIPT M A N U S C R I P T A C C E P T E D ACCEPTED MANUSCRIPTAbstract: The current study aimed to examine whether the APOE ε4 allele, associated with dementia with Lewy bodies (DLB), and possibly with dementia in Parkinson's disease (PD), is also associated with idiopathic REM sleep behavior disorder (RBD). Two SNPs, rs429358 and rs7412, were genotyped in RBD patients (n=480) and in controls (n=823). APOE ε4 allele frequency was 0.14 among RBD patients and 0.13 among controls (OR=1.11, 95% CI 0.88-1.40, p=0.41). APOE ε4 allele frequencies were similar in those who converted to DLB (0.14) and those who converted to PD (0.12) or multiple system atrophy (0.14, p=1.0). The APOE ε4 allele is neither a risk factor for RBD nor it is associated with conversion from RBD to DLB or other synucleinopathies.

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Section: Introductionmentioning

confidence: 99%

The dementia-associated APOE ε4 allele is not associated with rapid eye movement sleep behavior disorder

Gan‐Or

Montplaisir

Ross

et al. 2017

Neurobiology of Aging

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“…RBD is closely associated with PD (Munhoz and Teive, 2014), and patients suffering from idiopathic RBD (iRBD) are at great risk of subsequently developing Parkinsonism or dementia (Schenck et al, 2013(Schenck et al, , 2003(Schenck et al, , 1996. Several studies have focused on analysis of sleep data in the search for PD biomarkers (Dos Santos et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Sleep stability and transitions in patients with idiopathic REM sleep behavior disorder and patients with Parkinson’s disease

Christensen

Jennum

Koch

et al. 2016

Clinical Neurophysiology

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“…Longitudinal studies have shown that >80% of individuals with idiopathic REM sleep behavior disorder (RBD) developed Parkinson's disease (PD) or dementia with Lewy bodies (DLB) on long‐term follow‐up 1, 2, 3, 4, 5. RBD subjects represent a suitable group to study the prodromal stage of these disorders and may be crucial for disease‐modification trials.…”

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confidence: 99%

FDG PET, dopamine transporter SPECT, and olfaction: Combining biomarkers in REM sleep behavior disorder

et al. 2017

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BackgroundIdiopathic REM sleep behavior disorder is a prodromal stage of Parkinson's disease and dementia with Lewy bodies. Hyposmia, reduced dopamine transporter binding, and expression of the brain metabolic PD‐related pattern were each associated with increased risk of conversion to PD. The objective of this study was to study the relationship between the PD‐related pattern, dopamine transporter binding, and olfaction in idiopathic REM sleep behavior disorder.MethodsIn this cross‐sectional study, 21 idiopathic REM sleep behavior disorder subjects underwent 18F‐fluorodeoxyglucose PET, dopamine transporter imaging, and olfactory testing. For reference, we included 18F‐fluorodeoxyglucose PET data of 19 controls, 20 PD patients, and 22 patients with dementia with Lewy bodies. PD‐related pattern expression z‐scores were computed from all PET scans.ResultsPD‐related pattern expression was higher in idiopathic REM sleep behavior disorder subjects compared with controls (P = 0.048), but lower compared with PD (P = 0.001) and dementia with Lewy bodies (P < 0.0001). PD‐related pattern expression was higher in idiopathic REM sleep behavior disorder subjects with hyposmia and in subjects with an abnormal dopamine transporter scan (P < 0.05, uncorrected).ConclusionPD‐related pattern expression, dopamine transporter binding, and olfaction may provide complementary information for predicting phenoconversion. © 2017 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.

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Delayed emergence of a parkinsonian disorder or dementia in 81% of older men initially diagnosed with idiopathic rapid eye movement sleep behavior disorder: a 16-year update on a previously reported series

Cited by 682 publications

References 41 publications

The dementia-associated APOE ε4 allele is not associated with rapid eye movement sleep behavior disorder

The dementia-associated APOE ε4 allele is not associated with rapid eye movement sleep behavior disorder

Sleep stability and transitions in patients with idiopathic REM sleep behavior disorder and patients with Parkinson’s disease

FDG PET, dopamine transporter SPECT, and olfaction: Combining biomarkers in REM sleep behavior disorder

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