Delayed Cutaneous Metastasis of Gastric Carcinoma

Fujiwara, Sakuhei; Ichikawa, Hiroki; Matsunaga, Etsuji; Shinkai, Hiroshi; Takayasu, Susumu; Wada, Kyoko; Shinmoto, Hiroshi

doi:10.1111/j.1346-8138.1989.tb01257.x

Cited by 13 publications

(12 citation statements)

References 4 publications

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“…It represents a local extension of the breast carcinoma. However, it can be rarely seen in other carcinomas (lung, gastrointestinal tract and kidney) 87 . Histologically, the indurated areas show fibrosis and contain only a few tumor cells.…”

Section: Clinical Presentations Of the Skin Metastasesmentioning

confidence: 98%

“…The skin metastasis of gastric carcinoma may be in the form of cutaneous nodules, cellulitis, 18 carcinoma en cuirasse, infiltrated skin plaques, carcinoma erysipelatoides, 16 nodules 19 or a large cauliflower‐like papillomatous mass 17 . The carcinoma cells are seen in the middle and lower dermis, forming glands, clusters or strands of neoplastic cells in an abundance of fibrous stroma 87,88,150 (Fig. 4).…”

Section: Skin Metastases Of Carcinomasmentioning

confidence: 99%

“…However, it can be rarely seen in other carcinomas (lung, gastrointestinal tract and kidney). 87 Histologically, the indurated areas show fibrosis and contain only a few tumor cells. Telangiectatic metastatic carcinoma is characterized by violaceous papulovesicles resembling lymphangioma circumscriptum.…”

Section: Clinical Presentations Of the Skin Metastasesmentioning

confidence: 99%

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Skin metastasis: a pathologist's perspective

2010

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Skin metastasis is defined as the spread of malignant cells from a primary malignancy to the skin. It is one manifestation of systemic spread of cancer. The tumor cells originate either from an internal malignancy or from a primary skin cancer. This study presents a literature review concerning these issues as well as this author's experience encountered throughout 19 years of surgical pathology and dermatopathology practice. Several conclusions are evident. Generally, skin metastases are encountered in 0.7-9% of all patients with cancer and as such the skin is an uncommon site of metastatic disease when compared to other organs. There is usually a long-time lag between the diagnosis of the primary malignancy and the recognition of the skin metastases. However, these metastases may be the first indication of the clinically silent visceral malignancies. The regional distribution of the skin metastasis, although not always predictable, is related to the location of the primary malignancy and the mechanism of metastatic spread. The relative frequency of skin metastasis correlates with the type of primary cancer, which occurs in each sex. For instance, lung and breast carcinomas are the most common primaries that send skin metastasis in men and women, respectively. The head and neck region and the anterior chest are the areas of greatest predilection in men. The anterior chest wall and the abdomen are the most commonly involved sites in women. Skin metastases usually appear as non-specific groups of discrete firm painless nodules that emerge rapidly without any explanation. They vary in size from so tiny as to be of 'miliary lesions' to as large as 'Hen's egg size'. Some skin metastasis may mimic specific dermatological conditions such as cutaneous cyst, dermatofibroma, pyogenic granuloma, hemangioma, papular eruptions, herpes zoster eruptions, rapidly infiltrating plaques, alopecic patches, cellulitis and erysipelas. Histologically, the skin metastases usually show features reminiscent of the primary malignancy, but with variable degrees of differentiation. Molecularly, skin metastasis is an organized, non-random and organ-selective process orchestrated by interaction among several heterogeneous molecules, which are largely unknown. Metastasis to the skin is often a pre-terminal event that heralds poor outcome.

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Section: Clinical Presentations Of the Skin Metastasesmentioning

confidence: 98%

Section: Skin Metastases Of Carcinomasmentioning

confidence: 99%

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Skin metastasis: a pathologist's perspective

2010

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“…2,123,124 Sometimes, neoplastic cells show signet-ring cell morphology (Fig. 2,123,124 Sometimes, neoplastic cells show signet-ring cell morphology (Fig.…”

Section: Cutaneous Metastases From Gastrointestinal Cancer Colorectalmentioning

confidence: 99%

Cutaneous Metastases From Internal Malignancies

Alcaraz

Cerroni

Rütten

et al. 2012

The American Journal of Dermatopathology

220

104

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Skin metastases occur in 0.6%-10.4% of all patients with cancer and represent 2% of all skin tumors. Skin metastases from visceral malignancies are important for dermatologists and dermatopathologists because of their variable clinical appearance and presentation, frequent delay and failure in their diagnosis, relative proportion of different internal malignancies metastasizing to the skin, and impact on morbidity, prognosis, and treatment. Another factor to take into account is that cutaneous metastasis may be the first sign of clinically silent visceral cancer. The relative frequencies of metastatic skin disease tend to correlate with the frequency of the different types of primary cancer in each sex. Thus, women with skin metastases have the following distribution in decreasing order of frequency of primary malignancies: breast, ovary, oral cavity, lung, and large intestine. In men, the distribution is as follows: lung, large intestine, oral cavity, kidney, breast, esophagus, pancreas, stomach, and liver. A wide morphologic spectrum of clinical appearances has been described in cutaneous metastases. This variable clinical morphology included nodules, papules, plaques, tumors, and ulcers. From a histopathologic point of view, there are 4 main morphologic patterns of cutaneous metastases involving the dermis, namely, nodular, infiltrative, diffuse, and intravascular. Generally, cutaneous metastases herald a poor prognosis. The average survival time of patients with skin metastases is a few months. In this article, we review the clinicopathologic and immunohistochemical characteristics of cutaneous metastases from internal malignancies, classify the most common cutaneous metastases, and identify studies that may assist in diagnosing the origin of a cutaneous metastasis.

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“…Most cases present as firm, non‐ulcerated nodules 3 . But they can infrequently manifest as erysipelas‐like pattern, 3 scirrhous carcinoma, 6 zosteriform pattern or lesions resembling an epidermoid cyst 3 . In this case, the skin lesions looked like non‐specific contact dermatitis or photodermatoses, which is extremely rare manifestation of cutaneous metastases.…”

mentioning

confidence: 99%

Cutaneous metastasis of gastric signet ring cell carcinoma masquerading as allergic contact dermatitis

Ahn

Chang

et al. 2006

Acad Dermatol Venereol

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123 suggests they originate from hair follicle stem cells. J Cutan Pathol 1999; 26: 113 -118. 5 Lindberg K, Rheinwald JG. Suprabasal 40kd keratin (K19) expression as an immunohistologic marker of premalignancy in oral epithelium. Am J Pathol 1989; 134: 89-98. 6 Kurokawa I, Nishijima S, Kusumoto K, Senzaki H, Shikata N, Tsubura A. A case report of hidracanthoma simplex with an immunohistochemical study of cytokeratins. Int J Dermatol. in press. 7 Moll I, Moll R. Changes of expression of intermediate filament protein during ontogenesis of eccrine sweat glands. J Invest Dermatol 1992; 98: 777-785. 8 Hashimoto K, Gross Nelson et al. Eccrine spiradenoma. Histochemical and electron microscopic studies. J Invest Dermatol 1966; 46: 347-365. 9 Willey EL, Milchgrub S, Freeman RG, Kim ES. Sweat gland adenomas: immunohistochemical study with emphasis on myoepithelial differentiation.

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Delayed Cutaneous Metastasis of Gastric Carcinoma

Cited by 13 publications

References 4 publications

Skin metastasis: a pathologist's perspective

Skin metastasis: a pathologist's perspective

Cutaneous Metastases From Internal Malignancies

Cutaneous metastasis of gastric signet ring cell carcinoma masquerading as allergic contact dermatitis

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