A 69 year-old male Jehovah's Witness with a past medical history of non-ischemic cardiomyopathy, coronary artery disease (CAD), obesity, gout, and nephrolithiasis presented to a large academic medical center for evaluation for advanced options. He had a myocardial infarction in 2004, requiring a single stent to the left anterior descending artery. He was found to have an ejection fraction of 10% that was thought to be out-of-proportion to his CAD. His cardiac function did not improve with guideline-directed medical therapy, including a biventricular implantable cardioverter-defibrillator, and on presentation he was no longer able to tolerate significant neurohormonal blockade. Of note, family history was notable for a mother with a "large heart, " but the rest of his history was non-contributory. The patient was deemed a good candidate for advanced options, and he subsequently underwent bloodless orthotopic heart transplant (OHT) in June 2016.Initial post-operative transthoracic echocardiogram (TTE) showed a moderate pericardial effusion without hemodynamic compromise. Three weeks post-OHT, the patient developed various atrial arrhythmias, including blocked premature atrial contractions resulting in bradycardia and concerning for rejection. He underwent endomyocardial biopsy (EMB) which showed grade 0 rejection. The next day, a permanent pacemaker was implanted with the single right ventricular (RV) lead placed in the apical, septal region with active fixation. The following day, the temporary epicardial pacing leads were removed at bedside; removal of the second RV lead was complicated by resistance and induction of premature ventricular contractions. The next day, TTE was notable for hematoma in the myocardium of the RV and the apicolateral segment of the left ventricle (LV). Because of this finding, future monitoring for rejection was performed with TTE, and biopsy deferred for 4 weeks. On repeat TTE ten days later, the hematoma had resolved, and the patient had good graft function. Repeat EMB four weeks after the initial diagnosis of hematoma remained Grade 0.The patient has continued to have good cardiac function, without evidence of complication from the intraventricular hematoma, and he has not had any significant rejection in the first eleven months following OHT.