Delayed cell migration in the developing rat brain following maternal omega 3 alpha linolenic acid dietary deficiency

Yavin, Ephraïm; Himovichi, E.; Eilam, Raya

doi:10.1016/j.neuroscience.2009.05.012

Cited by 66 publications

(50 citation statements)

References 39 publications

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“…Therefore, the AD increase observed in the corpus callosum of the DEF rats may reflect a perturbation in axonal remodeling. It is of interest, therefore, that previous studies found that perinatal DHA-deficient rats exhibited impaired cell migration in the corpus callosum [60] and behavioral and neurochemical indices of cerebral asymmetry [58]. Additionally, we did not observe corresponding changes in FA or RD in the corpus callosum of DEF rats, suggesting that the observed increase in AD was not associated with changes in WMI.…”

Section: Discussioncontrasting

confidence: 45%

Deficits in Docosahexaenoic Acid Accrual during Adolescence Reduce Rat Forebrain White Matter Microstructural Integrity: An in vivo Diffusion Tensor Imaging Study

et al. 2017

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Neuropsychiatric disorders that frequently initially emerge during adolescence are associated with deficits in the omega-3 (n-3) fatty acid docosahexaenoic acid (DHA), elevated proinflammatory signaling, and regional reductions in white matter integrity (WMI). This study determined the effects of altering brain DHA accrual during adolescence on WMI in the rat brain by diffusion tensor imaging (DTI), and investigated the potential mediating role of proinflammatory signaling. During periadolescent development, male rats were fed a diet deficient in n-3 fatty acids (DEF, n = 20), a fish oil-fortified diet containing preformed DHA (FO, n = 20), or a control diet (CON, n = 20). In adulthood, DTI scans were performed and brain WMI was determined using voxelwise tract-based spatial statistics (TBSS). Postmortem fatty acid composition, peripheral (plasma IL-1β, IL-6, and C-reactive protein [CRP]) and central (IL-1β and CD11b mRNA) proinflammatory markers, and myelin basic protein (MBP) mRNA expression were determined. Compared with CON rats, forebrain DHA levels were lower in DEF rats and higher in FO rats. Compared with CON rats, DEF rats exhibited greater radial diffusivity (RD) and mean diffusivity in the right external capsule, and greater axial diffusivity in the corpus callosum genu and left external capsule. DEF rats also exhibited greater RD than FO rats in the right external capsule. Forebrain MBP expression did not differ between groups. Compared with CON rats, central (IL-1β and CD11b) and peripheral (IL-1β and IL-6) proinflammatory markers were not different in DEF rats, and DEF rats exhibited lower CRP levels. These findings demonstrate that deficits in adolescent DHA accrual negatively impact forebrain WMI, independently of elevated proinflammatory signaling.

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Section: Discussioncontrasting

confidence: 45%

Deficits in Docosahexaenoic Acid Accrual during Adolescence Reduce Rat Forebrain White Matter Microstructural Integrity: An in vivo Diffusion Tensor Imaging Study

et al. 2017

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“…However, the mechanisms underlying these effects are still unclear. Omega-3 PUFAs have been shown to influence developmental neurogenesis, where several studies have reported that omega-3 PUFA deficiency in embryonic and newborn rats leads to decreased neurogenesis and delay or inhibition of normal development (Coti Bertrand et al, 2006;Yavin et al, 2009;Kawakita et al, 2006). It may therefore be hypothesised that omega-3 PUFA may enhance hippocampal function via effects on adult neurogenesis.…”

Section: Omega-3 Pufas and Adult Hippocampal Neurogenesismentioning

confidence: 99%

The role of omega-3 fatty acids in adult hippocampal neurogenesis

Dyall

2011

OCL

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“…Fat Intake and CNS Functioning: Ageing and Disease Ann Nutr Metab 2009;55:202-228 203 et al, 2007], delayed cell migration in the developing brain [Yavin et al, 2009] and an increase in depressive and aggressive behaviour [DeMar et al, 2006].…”

Section: Brain Compositionmentioning

confidence: 99%