Delayed caffeine treatment prevents nigral dopamine neuron loss in a progressive rat model of Parkinson's disease

Sonsalla, Patricia K.; Wong, Lai Yoong; Harris, Suzan L.; Richardson, Jason R.; Khobahy, Ida; Li, Wenhao; Gadad, Bharathi S.; German, Dwight C.

doi:10.1016/j.expneurol.2012.01.022

Cited by 84 publications

(81 citation statements)

References 37 publications

(53 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Further, Caffeine partially restored DA metabolites in rats following 6-OHDA lesions [55] and provided significant neuroprotection in MPTP models of PD. Interestingly, with caffeine intake, neuroprotection was evidenced even after the onset of neurodegeneration in rats [57].…”

Section: Common Beveragesmentioning

confidence: 98%

“…Accordingly, the ability of caffeine to down-regulate NO production, neuroinflammation, and microglial activation through these pathways are speculated to contribute to neuroprotection [56]. Recent evidence indicate that caffeine reduces dopaminergic toxicity and slows disease progression through the antagonism of adenosine vA2A receptors [57]. Hence, currently, clinical studies are underway to evaluate several lA2A receptor antagonists for symptomatic relief and slowing of disease progression [59].…”

Section: Common Beveragesmentioning

confidence: 99%

See 1 more Smart Citation

Current Understanding on the Beneficial Role of Nutrition in Parkinson’s Disease –An Overview

Muralidhara¹,

Sv²,

SC³

2017

J Aging Sci

View full text Add to dashboard Cite

Various nutritional components belonging to different classes of natural dietary origin display modulatory (protective) properties against age-related neurodegenerative disorders (NDD) such as Parkinson's disease (PD) and Alzheimer's disease. These compounds termed as nutraceuticals which have been shown to act at various biochemical and metabolic levels and exhibit different degree of neuroprotective properties. Present review aims to summarize the current status on the modulatory impact of some of the major nutritional compounds on the pathophysiology of PD, the second most common NDD in humans. Primarily, we have examined the data demonstrated in animal models and postulated through epidemiological studies on the compounds/molecules/life style factors which reduce the risk associated with PD and probable mechanism/s through which they elicit neuroprotection. Further we also included some of the conflicting information about the compounds which may enhance the risk associated with PD. Additionally, emphasis is also given about the new approaches to understand the impact of nutrition on the epigenome in relation to the development of NDD with a short note on emerging ideas relating to nutritional genomics.

show abstract

Section: Common Beveragesmentioning

confidence: 98%

Section: Common Beveragesmentioning

confidence: 99%

Current Understanding on the Beneficial Role of Nutrition in Parkinson’s Disease –An Overview

Muralidhara¹,

Sv²,

SC³

2017

J Aging Sci

View full text Add to dashboard Cite

show abstract

“…Protects contrary to oxidative stress and AD-like pathology in rabbit hippocampus [65]. Inhibits the loss of nigral dopaminergic neurons [66].…”

Section: Caffeinementioning

confidence: 99%

“…Table 1: Effects of caffeine on neurodegenerative disorders [59][60][61][62][63][64][65][66][67][68].…”

Section: Caffeinementioning

confidence: 99%

Neuropsychological Effects of Caffeine: Is Caffeine Addictive?

Sufian¹,

Hossain²,

Kabir³

et al. 2017

J Psychol Psychother

View full text Add to dashboard Cite

Caffeine is the most widely used psychotropic drug in the world. Most of the caffeine consumed comes from coffee bean (i.e., a misnomer for the seed of Coffea plants), beverages (i.e., coffee, tea, soft drinks), in products containing cocoa or chocolate and in medications (i.e., analgesics, stimulants, weight-loss products, sports nutrition). The most prominent behavioral effects of caffeine take place over low to moderate doses are amplified alertness and attention. Moderate caffeine consumption leads very rarely to health risks.

show abstract

“…In addition, caffeine was shown to increase glutathione S-transferase activity and prevent the deterioration of red blood cells and apoptosis (11). In addition, due to being a strong assembler of hydroxyl radicals, the effects of caffeine on neurodegenerative disorders have been examined on a large scale in the last decade (12).…”

mentioning

confidence: 99%

The effect of caffeine on neuron number of rats exposed to 900-MHz electromagnetic field

2018

Turk J Vet Anim Sci

View full text Add to dashboard Cite

IntroductionRecently, an increasing number of studies have investigated whether an electromagnetic field (EMF) has harmful effects on human health. The number of masses influenced by the radiofrequency waves radiated by base stations and cell phones increases as time goes by. In particular cell phones, which provide useful services to humans, are thought to have many harmful effects (1). The effects of EMF on the tissues and organs of human beings are frequently investigated (2). The most outstanding of these are studies that present the effects of EMF on central nervous system diseases and brain functions.Radio waves that occupy the frequency range from 3 kHz to 300 GHz are forms of electromagnetic energy. The devices working in this frequency range form an impact area called radiofrequency EMF. Cell phones operate in the frequency range of 800-2600 MHz. The third-and fourthgeneration mobile phones use microwaves of 1800-2100 MHz whereas second-generation phones operate at 900 MHz, which is still the most commonly used mobile communication system (3).Since developing tissues and organs are very sensitive to harmful agents, the potential harmful effects of microwaves on children have been assessed in the agenda of the World Health Organization since 2006, and continuous studies are being conducted on the subject (4). A wide-scale casecontrol study conducted by two different research centers has examined the relationship between brain tumors and cell phone use. One of these studies found a significant association between cell phone use and malignant brain tumors (4). On the other hand, another study reported that cell phone use of 10 years did not increase the risk for acoustic neuroma, and it was also mentioned that 10year cell phone use was not long enough for neuroma development. (5). Exposure to 900-MHz EMF was shown to decrease the number of Purkinje cells in the cerebellum (3).Caffeine (1,3,7-trimethylxanthine), is a psychostimulant consumed in great amounts in Western countries (6). This purine alkaloid, which has a formula of C 8 H 10 N 4 O 2 , is found in coffee, tea, energy drinks, various soft drinks, and cacao. In addition, it is naturally found in the fruits, seeds, and leaves of many plants (7).Although it changes from person to person, people generally consume some caffeine every day without even realizing it. A brewed coffee drink of 437 mL contains an average of 188 mg of caffeine. The caffeine concentration in coffee beans can differ between 0.01 mg/g and 19.9 mg/g.

show abstract

Delayed caffeine treatment prevents nigral dopamine neuron loss in a progressive rat model of Parkinson's disease

Cited by 84 publications

References 37 publications

Current Understanding on the Beneficial Role of Nutrition in Parkinson’s Disease –An Overview

Current Understanding on the Beneficial Role of Nutrition in Parkinson’s Disease –An Overview

Neuropsychological Effects of Caffeine: Is Caffeine Addictive?

The effect of caffeine on neuron number of rats exposed to 900-MHz electromagnetic field

Contact Info

Product

Resources

About