Delayed bullous pressure urticaria: the puzzling role of eosinophils

Bullous delayed‐pressure urticaria masquerading as safety footwear contact dermatitis

“…Epidermal blisters filled with eosinophils, and eosinophilic dermal infiltration can be observed in a skin biopsy. A favorable response to omalizumab has been reported in two cases 1,2 …”

“…The use of face masks is mandatory in many countries in order to prevent transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) during the ongoing coronavirus disease pandemic (COVID-19) pandemic. 1,2 In Denmark, it was mandatory to wear face masks at all hospitals during November 2020 to June 2021. 2 However, the increased use of face masks may lead to facial skin complaints.…”

“…A favorable response to omalizumab has been reported in two cases. 1,2 Differential diagnoses of DPU include other disorders involving significant cutaneous eosinophil infiltration, such as allergic contact dermatitis to footwear allergens and photoallergic contact dermatitis from ketoprofen, 3 the latter of which may also be misdiagnosed as erysipelas.…”

“…1,2 In Denmark, it was mandatory to wear face masks at all hospitals during November 2020 to June 2021. 2 However, the increased use of face masks may lead to facial skin complaints. To access the nature of these adverse reactions, our department opened for referral of staff from all departments at our hospital if significant skin problems were associated with the use of face masks.…”