Delayed and diminished postprandial lactate shuttling in healthy older men and women
Jose A. Arevalo,
Robert G. Leija,
Adam D. Osmond
et al.
Abstract:Lactate, a product of glycolysis, is formed under aerobic conditions. Extensive work has shown lactate flux in young and exercising humans; however, the effect of age is not known. We tested the hypothesis that postprandial lactate shuttling (PLS) would be diminished in older adults. We used [3-13C]lactate and [6,6-2H]-glucose tracers, an OGTT, and arterialized blood sampling to determine postprandial lactate rates of appearance (Ra), disappearance (Rd), and oxidation (Rox) in 15 young (28.1 ± 1.4 yr) and 13 o… Show more
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