Delayed administration of Trichilia catigua A. Juss. Ethyl-acetate fraction after cerebral ischemia prevents spatial memory deficits, decreases oxidative stress, and impacts neural plasticity in rats

Oliveira, Daniela Velasquez; Godinho, Jacqueline; Sá‐Nakanishi, Anacharis Babeto de; Comar, Jurandir Fernando; Oliveira, Rúbia Maria Weffort de; Bonato, Jéssica Mendes; Chinen, Luana Yukari; Paula, Mariana Nascimento de; Mello, João Carlos Palazzo de; Previdelli, Isolde Santos; Pereira, Omar Cléo Neves; Milani, Humberto

doi:10.1016/j.jep.2023.116176

Cited by 4 publications

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Melatonin improves maternal sleep deprivation‐induced learning and memory impairment, inflammation, and synaptic dysfunction in murine male adult offspring

Zhang,

Wei,

et al. 2024

Brain and Behavior

View full text Add to dashboard Cite

IntroductionMaternal sleep deprivation (MSD), which induces inflammation and synaptic dysfunction in the hippocampus, has been associated with learning and memory impairment in offspring. Melatonin (Mel) has been shown to have anti‐inflammatory, antioxidant, and neuroprotective function. However, the beneficial effect of Mel on MSD‐induced cognitive impairment and its mechanisms are unknown.MethodsIn the present study, adult offspring suffered from MSD were injected with Mel (20 mg/kg) once a day during postnatal days 61–88. The cognitive function was evaluated by the Morris water maze test. Levels of proinflammatory cytokines were examined by enzyme‐linked immunosorbent assay. The mRNA and protein levels of synaptic plasticity associated proteins were examined using reverse transcription‐polymerase chain reaction and western blotting.ResultsThe results showed that MSD impaired learning and memory in the offspring mice. MSD increased the levels of interleukin (IL)‐1creIL‐6, and tumor necrosis factor‐α and decreased the expression levels of brain‐derived neurotrophic factor, tyrosine kinase receptor B, postsynaptic density protein‐95, and synaptophysin in the hippocampus. Furthermore, Mel attenuated cognitive impairment and restored markers of inflammation and synaptic plasticity to control levels.ConclusionsThese findings indicated that Mel could ameliorate learning and memory impairment induced by MSD, and these beneficial effects were related to improvement in inflammation and synaptic dysfunction.

show abstract

Melatonin improves maternal sleep deprivation‐induced learning and memory impairment, inflammation, and synaptic dysfunction in murine male adult offspring

Zhang,

Wei,

et al. 2024

Brain and Behavior

View full text Add to dashboard Cite

show abstract

Effects of oxidative stress on hepatic encephalopathy pathogenesis in mice

Bai

et al. 2023

Nat Commun

View full text Add to dashboard Cite

Oxidative stress plays a crucial role in the pathogenesis of hepatic encephalopathy (HE), but the mechanism remains unclear. GABAergic neurons in substantia nigra pars reticulata (SNr) contribute to the motor deficit of HE. The present study aims to investigate the effects of oxidative stress on HE in male mice. The results validate the existence of oxidative stress in both liver and SNr across two murine models of HE induced by thioacetamide (TAA) and bile duct ligation (BDL). Systemic mitochondria-targeted antioxidative drug mitoquinone (Mito-Q) rescues mitochondrial dysfunction and oxidative injury in SNr, so as to restore the locomotor impairment in TAA and BDL mice. Furthermore, the GAD2-expressing SNr population (SNrGAD2) is activated by HE. Both overexpression of mitochondrial uncoupling protein 2 (UCP2) targeted to SNrGAD2 and SNrGAD2-targeted chemogenetic inhibition targeted to SNrGAD2 rescue mitochondrial dysfunction in TAA-induced HE. These results define the key role of oxidative stress in the pathogenesis of HE.

show abstract

Neuroprotective Effects of Boswellia Dalzielii Extract Against Focal Cerebral Ischemia-Reperfusion Injury in Rats

Hamadjida,

Foudjih,

Amayapa

et al. 2023

Preprint

View full text Add to dashboard Cite

Delayed administration of Trichilia catigua A. Juss. Ethyl-acetate fraction after cerebral ischemia prevents spatial memory deficits, decreases oxidative stress, and impacts neural plasticity in rats

Cited by 4 publications

References 48 publications

Melatonin improves maternal sleep deprivation‐induced learning and memory impairment, inflammation, and synaptic dysfunction in murine male adult offspring

Melatonin improves maternal sleep deprivation‐induced learning and memory impairment, inflammation, and synaptic dysfunction in murine male adult offspring

Effects of oxidative stress on hepatic encephalopathy pathogenesis in mice

Neuroprotective Effects of Boswellia Dalzielii Extract Against Focal Cerebral Ischemia-Reperfusion Injury in Rats

Contact Info

Product

Resources

About