Delay of simple reaction time after levodopa intake

Müller, Thomas; Benz, Sabine; Börnke, Christian

doi:10.1016/s1388-2457(01)00653-8

Cited by 24 publications

(19 citation statements)

References 49 publications

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“…We found an improvement in motor symptoms during DBS similar to that achieved with acute levodopa in previous trials [10,16,17,18]. Accordingly, there was a better performance of the peg insertion task, which does not only reflect altered movement behavior, but also requires higher cognitive functions [11].…”

Section: Discussionsupporting

confidence: 79%

“…RT and MT were assessed by computer to millisecond accuracy. Out of 14 correct answers we used a truncated mean of values for statistical analysis, which excludes measures greater than or less than 2 standard deviations of the mean value [10]. …”

Section: Methodsmentioning

confidence: 99%

“…At least partially, the investigators compared their results with the effects found following acute levodopa administration in PD patients [6,7,8,9]. Changes of motor behavior and cognitive function and the interaction between the two may also be studied with various instrumental tasks in a standardized fashion in order to demonstrate the effects of antiparkinsonian drugs [10, 11]. Performance of these instrumental tests involves various domains of cognition, which includes different kinds of cognitive load with demand for visual or acoustic perception and control.…”

Section: Introductionmentioning

confidence: 99%

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Deep Brain Stimulation Improves Performance of Complex Instrumental Paradigms

Ellrichmann¹,

Harati²,

Müller³

2008

Eur Neurol

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Patients with Parkinson’s disease (PD) show deficits of motion behaviour and cognitive function, which were assessed with various instrumental paradigms. Objectives of the present trial were to investigate the effects of bilateral deep brain stimulation (DBS) of the subthalamic nucleus (STN) on the performance of complex and simple movement series, on the execution of simple reaction time (SRT) paradigms following an acoustic or a visual stimulus, on scored motor symptoms and the interrelation of the various study parameters in PD patients. Motor symptoms, operation of complex movements, and the execution of SRT tasks significantly improved when the stimulator was switched on. Execution of simple movement series did not differ between the on and off conditions of the stimulator. Instrumental test results significantly correlated with scored motor symptoms in particular during the off condition. During the on state, significant correlations were found between the performance of complex motion sequences and the SRT outcomes. PD patients treated with DBS of the STN show better results for more complex instrumental paradigms with a higher need for cognitive effort during the on situation due to improvements in motor performance, function of the basal ganglia-thalamocortical circuitry and cognitive function.

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Section: Discussionsupporting

confidence: 79%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Deep Brain Stimulation Improves Performance of Complex Instrumental Paradigms

Ellrichmann¹,

Harati²,

Müller³

2008

Eur Neurol

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“…It is classically considered in the literature that RT corresponds to perceptual-decisional-programming aspects of information processing while MT reflects response execution. MT and RT have been frequently affected by different task factors and pharmacological manipulations in previous works Dunnett 1997, 1998;Müller et al 2001;Warshawsky-Livne and Shinar 2002). The effects observed on MT are therefore irrelevant to the decomposition of information processing into stages and must be considered differently from the RT data.…”

Section: Movement Timementioning

confidence: 97%

An additive factor analysis of the effect of sub-anaesthetic doses of nitrous oxide on information processing: evidence for an impairment of the motor adjustment stage

et al. 2003

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The present data provide evidence that N(2)O impairs information processing by altering at least the stage of motor adjustment. In addition, N(2)O spares the sensory processes implemented during the stimulus preprocessing stage. A subsidiary result is that at some concentrations, N(2)O displays opposite effects on reaction time and movement time. These results demonstrate that the additive factor method constitutes a powerful new tool for studying the pharmacology of information processing in animal models.

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“…Changes in cognition during dopaminergic therapy are likely to be task-specific and dependent upon disease stage, perhaps relating to the extent and spatial distribution of dopaminergic denervation [Cools et al, 2001;Kulisevsky 2000;Muller et al, 2001;Owen et al, 1997]. The effects of deep brain stimulation (DBS) on cognitive functioning have also been inconsistent.…”

Section: Introductionmentioning

confidence: 99%

Learning networks in health and Parkinson's disease: Reproducibility and treatment effects

Carbon

Ghilardi

Feigin

et al. 2003

Human Brain Mapping

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In a previous H(2) (15)O/PET study of motor sequence learning, we used principal components analysis (PCA) of region of interest (ROI) data to identify performance-related activation patterns in normal subjects and patients with Parkinson's disease (PD). In the present study, we determined whether these patterns predicted learning performance in subsequent normal and untreated PD cohorts. Using a voxel-based PCA approach, we correlated the changes in network activity that occurred during antiparkinsonian treatment and their relationship to learning performance. We found that the previously identified ROI-based patterns correlated with learning performance in the prospective normal (P < 0.01) and untreated PD (P < 0.05) cohorts. Voxel analysis revealed that target retrieval was related to a network characterized by bilateral activation of the dorsolateral prefrontal, premotor and anterior cingulate cortex, the precuneus, and the occipital association areas as well as the right ventral prefrontal and inferior parietal regions. Target acquisition was associated with a different network involving activation of the caudate, putamen, and right dentate nucleus, as well as the left ventral prefrontal and inferior parietal areas. Antiparkinsonian therapy gave rise to changes in retrieval performance that correlated with network modulation (P < 0.01). Increases in network activation and learning performance occurred with internal pallidal deep brain stimulation (GPi DBS); decrements in these measures were present with levodopa. Our findings suggest that network analysis of activation data can provide stable descriptors of learning performance. Network quantification can provide an objective means of assessing the effects of therapy on cognitive functioning in neurodegenerative disorders.

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Delay of simple reaction time after levodopa intake

Cited by 24 publications

References 49 publications

Deep Brain Stimulation Improves Performance of Complex Instrumental Paradigms

Deep Brain Stimulation Improves Performance of Complex Instrumental Paradigms

An additive factor analysis of the effect of sub-anaesthetic doses of nitrous oxide on information processing: evidence for an impairment of the motor adjustment stage

Learning networks in health and Parkinson's disease: Reproducibility and treatment effects

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