Delay of innate immune responses following influenza B virus infection affects the development of robust antibody response in ferrets
Thomas Rowe,
Ashley Fletcher,
Robert A Richardson
et al.
Abstract:Due to its natural influenza susceptibility, clinical signs, transmission, and similar sialic acid residue distribution, the ferret is the primary animal model for human influenza research. Antibodies generated following infection of ferrets with human influenza viruses are used in surveillance to detect antigenic drift and cross-reactivity with vaccine viruses and circulating strains. Inoculation of ferrets, with over 1500 human clinical influenza isolates (1998-2019) resulted in lower antibody responses (HI&… Show more
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