Delay of cortical thinning in very preterm born children

Mürner-Lavanchy, Ines; Steinlin, Maja; Nelle, Mathias; Rummel, Christian; Perrig, Walter J.; Schroth, Gerhard; Everts, Regula

doi:10.1016/j.earlhumdev.2014.05.013

Cited by 33 publications

(39 citation statements)

References 37 publications

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“…Aanes, Bjuland, Skranes, & Løhaugen, 2015;Meng et al, 2016), although whenNagy et al (2009) controlled for TBV, all subcortical differences disappeared. This model of catch-up is supported by recent work in adults suggesting that there is accelerated maturation toward adulthood in the VPT(Karolis et al, 2017;Mürner-Lavanchy et al, 2014). As the cortical thickness differences were concordant with slower cortical thinning, this may well be an aspect of brain structure where there is some catch up to their FT peers.…”

supporting

confidence: 64%

Mapping the neuroanatomical impact of very preterm birth across childhood

Vandewouw

Young

Mossad

et al. 2019

Human Brain Mapping

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Those born very preterm (VPT; <32 weeks gestational age) have an increased risk in developing a wide range of cognitive deficits. In early-to-late childhood, brain structure has been shown to be altered in VPT compared to full-term (FT) children; however, the results are inconsistent. The current study examined subcortical volumes, cortical thickness, and surface area in a large cohort of VPT and FT children aged 4-12 years. Structural magnetic resonance imaging (MRI) was obtained on 120 VPT and 146 FT children who returned up to three times, resulting in 176 VPT and 173 FT unique data points. For each participant, Corticometric Iterative Vertex-based Estimation of Thickness was used to obtain global measurements of total brain, cortical grey and cortical white matter volumes, along with surface-based measurements of cortical thickness and surface area, and Multiple Automatically Generated Templates (MAGeT) brain segmentation tool was used to segment the subcortical structures. To examine group differences and group-age interactions, mixed-effects models were used (controlling for whole-brain volume). We found few differences between the two groups in subcortical volumes. The VPT children showed increased cortical thickness in frontal, occipital and fusiform gyri and inferior pre-post-central areas, while thinning occurred in the midcingulate. Cortical thickness in occipital regions showed more rapid decreases with age in the VPT compared to the FT children. VPT children also showed both regional increases, particularly in the temporal lobe, and decreases in surface area. Our results indicate a delayed maturational trajectory in those born VPT.K E Y W O R D S brain structure, child development, magnetic resonance imaging, preterm birth

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supporting

confidence: 64%

Mapping the neuroanatomical impact of very preterm birth across childhood

Vandewouw

Young

Mossad

et al. 2019

Human Brain Mapping

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“…Therefore, the VPT individuals studied here may not be representative of contemporary cohorts, who may have improved neurodevelopmental outcomes (Serenius et al, 2013). However, studies with younger samples have reported alterations in similar cortical areas (Murner-Lavanchy et al, 2014), supporting the idea of regional vulnerability following VPT birth. A further limitation is the inclusion of term-born controls from the general population, which could differ from our study group in variables that have not been measured.…”

Section: Discussionmentioning

confidence: 61%

Alterations in cortical thickness development in preterm-born individuals: Implications for high-order cognitive functions

et al. 2015

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Very preterm birth (gestational age < 33 weeks) is associated with alterations in cortical thickness and with neuropsychological/behavioural impairments. Here we studied cortical thickness in very preterm born individuals and controls in mid-adolescence (mean age 15 years) and beginning of adulthood (mean age 20 years), as well as longitudinal changes between the two time points. Using univariate approaches, we showed both increases and decreases in cortical thickness in very preterm born individuals compared to controls. Specifically (1) very preterm born adolescents displayed extensive areas of greater cortical thickness, especially in occipitotemporal and prefrontal cortices, differences which decreased substantially by early adulthood; (2) at both time points, very preterm-born participants showed smaller cortical thickness, especially in parahippocampal and insular regions. We then employed a multivariate approach (support vector machine) to study spatially discriminating features between the two groups, which achieved a mean accuracy of 86.5%. The spatially distributed regions in which cortical thickness best discriminated between the groups (top 5%) included temporal, occipitotemporal, parietal and prefrontal cortices. Within these spatially distributed regions (top 1%), longitudinal changes in cortical thickness in left temporal pole, right occipitotemporal gyrus and left superior parietal lobe were significantly associated with scores on language-based tests of executive function. These results describe alterations in cortical thickness development in preterm-born individuals in their second decade of life, with implications for high-order cognitive processing.

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“…Low BW is associated with reduced cortical thickness [Bjuland et al, 2013], surface area [Ajayi-Obe et al, 2000;Skranes et al, 2013], and volume [Ball et al, 2012] in infants and adolescents, and these reductions appear to be related to cognitive deficits [Bjuland et al, 2013;Schlotz et al, 2014;Skranes et al, 2013;Walhovd et al, 2004]. Preterm children with very low BW show significant delays in the development of cortical thickness, relative to normal weight children [M€ urner-Lavanchy et al, 2014].…”

Section: Introductionmentioning

confidence: 99%