Delay of Adjuvant Chemotherapy After Elective Mastectomy and Immediate Reconstruction in Breast-conservation Candidates

Abstract

The use of M-IR in breast-conservation candidates independently predicts for delay in initiation of adjuvant chemotherapy. Further study is needed to qualify the causes and clinical significance of these delays.

Factors Associated With Delays in Chemotherapy Initiation Among Patients With Breast Cancer at a Comprehensive Cancer Center

“…21 Multiple factors, including age, disease-specific characteristics, type of surgical procedure, and additional testing have been found to influence this trend. [21][22][23][24][25][26][27] In an era of increasing use of Oncotype DX to assist with chemotherapy treatment decisions, an aging population with comorbidities needing to be addressed, and the more prevalent use of MIR, it is not surprising that wait times to adjuvant therapy continue to increase.…”

Tolérance du lambeau de grand dorsal sans prothèse à la radiothérapie en reconstruction mammaire immédiate

“…La sécurité carcinologique de la RMI étant démontrée, une augmentation croissante du nombre de procédure de RMI est observée avec l'année de prise en charge du cancer [2,4]. De même, concernant les délais à l'initiation des traitements adjuvants, la RMI est associée avec une augmentation modérée, cliniquement non significative, avec un délai supplémentaire moyen de 2 semaines environ en fonction des séries [16,17]. Dans notre étude, le délai moyen entre le début du premier traitement adjuvant (chimiothérapie si elle était indiquée en premier, puis radiothérapie systéma-tique) est de 40 jours, ce qui est comparable aux délais habituellement observés.…”

De-Mythifying Breast Reconstruction: A Review of Common Misconceptions about Breast Reconstruction

“…Patients undergoing mastectomy with immediate reconstruction were more likely to experience a significant delay in the initiation of chemotherapy (>90 days; 7 patients [20.0%] vs 1 patient [2.9%]; p < 0.001). 25 It is not clear that this is in fact a clinically significant "delay" because it falls within the large window of acceptable timing for treatment. In addition, the matching in this case might also be imperfect for numerous reasons.…”