Del1 Is a Growth Factor for Skeletal Progenitor Cells in the Fracture Callus
Yuxi Sun,
Tatiana Boyko,
Owen Marecic
et al.
Abstract:Failure to properly form bone or integrate surgical implants can lead to morbidity and additional surgical interventions in a significant proportion of orthopedic surgeries. While the role of skeletal stem cells (SSCs) in bone formation and repair is well-established, very little is known about the factors that regulate the downstream Bone, Cartilage, Stromal, Progenitors (BCSPs). BCSPs, as transit amplifying progenitor cells, undergo multiple mitotic divisions to expand the pool of lineage committed progenito… Show more
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