DEK over expression as an independent biomarker for poor prognosis in colorectal cancer

Lin, Lijuan; Piao, Jinhua; Gao, Wenbin; Piao, Yingshi; Jin, Guang; Ma, Yue; Li, Jinzi; Lin, Zhenhua

doi:10.1186/1471-2407-13-366

Cited by 55 publications

(75 citation statements)

References 31 publications

(37 reference statements)

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“…which is consistent with previous reports (Wang et al 2013a, b;Lin et al 2013). Furthermore, all the biomarkers are averagely higher or lower than those in healthy subjects (Fig.…”

Section: Discussionsupporting

confidence: 93%

“…Here, we found that the protein level of DEK was higher when the CRC patients were at advanced stage (Figs. 3 and 4), which was consistent with a previous report that DEK played an important role in the progression of CRC and it was an independent poor prognostic factor of CRC (Lin et al 2013). …”

Section: The Protein Levels Of Hv1 Mxra5 Pias3 and Dek In Crc Patientssupporting

confidence: 92%

“…High expression levels of the human DEK gene have been correlated with numerous human malignancies (Privette Vinnedge et al 2013). DEK also plays an important role in the progression of CRC and is an independent poor prognostic factor of CRC (Lin et al 2013). All these biomarkers offer a great convenience in the diagnosis of CRC.…”

Section: Introductionmentioning

confidence: 99%

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Association of Sedentary Behavior with the Expression Levels of Biomarkers in Colorectal Cancer: Clinical Analysis of 228 Patients

Takata

Lü

et al. 2014

Tohoku J. Exp. Med.

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There is an association between sedentary behavior and the risk of colorectal cancer (CRC), but the underlying mechanism is unclear. CRC is characterized by the changes in the expression levels of biomarkers, including voltage-gated proton channel Hv1, matrix-remodeling associated 5 (MXRA5), DEK (inducing positive supercoils into circular DNA) and protein inhibitor of activated signal transducer and activators of transcription 3 (PIAS3). Thus, sedentary behavior may affect the expression levels of these biomarkers in the colorectal tissue. Here, we recruited 228 CRC patients (128 males, 57.8 ± 7.8 years; 100 females, 57.7 ± 7.5 years) and 80 healthy subjects (48 males, 57.5 ± 6.8 years; 32 females, 56.9 ± 6.5 years) from March 7th, 2010 to May 6th, 2012. All the subjects were unrelated Han Chinese with the similar cultural and economic background. All the subjects were interviewed concerning sedentary time (sitting time categories: less than 1, 1-3, 4-6, and more than 6 h/day). The daily sedentary time of most CRC patients was more than 4 h/day, while the sedentary time of most healthy subjects was less than 3 h/ day. The expression levels of Hv1, MXRA5 and DEK mRNAs and proteins were higher in CRC tissues and the levels of PIAS3 mRNA and protein were lower when the daily sedentary time was longer in CRC patients (p < 0.05). The daily sedentary time was correlated with the protein levels of CRC biomarkers. Furthermore, the sedentary time was positively related with body mass index but not daily calorie intake.

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“…which is consistent with previous reports (Wang et al 2013a, b;Lin et al 2013). Furthermore, all the biomarkers are averagely higher or lower than those in healthy subjects (Fig.…”

Section: Discussionsupporting

confidence: 93%

Section: The Protein Levels Of Hv1 Mxra5 Pias3 and Dek In Crc Patientssupporting

confidence: 92%

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Association of Sedentary Behavior with the Expression Levels of Biomarkers in Colorectal Cancer: Clinical Analysis of 228 Patients

Takata

Lü

et al. 2014

Tohoku J. Exp. Med.

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“…High level of DEK is closely correlated with the tumor size, grade, metastasis, and patient survival. 19,24,25 HCC patients with DEK expression showed a lower 5-year survival rate compared with the patients without DEK expression. 25 DEK overexpression is also associated with the poor prognosis of patients with highgrade neuroendocrine carcinoma.…”

Section: Discussionmentioning

confidence: 93%

DEK proto-oncogene is highly expressed in astrocytic tumors and regulates glioblastoma cell proliferation and apoptosis

Feng

Liu

et al. 2017

Tumour Biol.

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Astrocytic tumors are the most common neuroepithelial neoplasms with high relapse rate after surgery. Understanding the molecular mechanisms for astrocytic tumorigenesis and progression will lead to early diagnosis and effective treatment of astrocytic tumors. The DEK mRNA and protein expression in normal brain tissues and astrocytic tumors was quantified. To investigate DEK functions in tumor cells, DEK gene was silenced with siRNA in U251 glioblastoma cells. Cell proliferation, cell cycle and apoptosis were then measured. The expression and activity of key genes that regulate cell proliferation and apoptosis were also measured. We identified DEK as a high expressed gene in astrocytic tumor tissues. DEK expression level was positively correlated with the pathological grade of astrocytic tumors. Gene silencing of DEK in U251 glioblastomas inhibited cell proliferation and blocked cells at G0/G1 phase of cell cycle. DEK depletion also induced cell apoptosis, with up-regulated expression of P53 and P21 and down-regulated expression of Bcl-2 and C-myc. The Caspase-3 activity in U251 cells was also significantly increased after knockdown. Our results provided evidences that DEK regulates proliferation and apoptosis of glioblastomas. DEK gene silencing may induce apoptosis through P53-dependent pathway. Our data indicated DEK plays multiple roles to facilitate tumor growth and maintenance. It can be used as a potential target for astrocytic tumor diagnosis and gene therapy.

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“…In the study, the demonstration that DEK expression is associated with the proliferative index of cells and cervical cancer is important for the diagnosis of precancerous lesions. Furthermore, according to the results from tumor tissue analysis, previous studies reported that DEK expression was associated with the development of human colorectal cancer, and was proposed as a novel molecular target for cancer treatment (14). However, to the best of our knowledge, there have been no studies to support the increase in DEK protein expression in patients with gastric adenocarcinoma.…”

Section: Introductionmentioning

confidence: 99%

Overexpression of DEK is an indicator of poor prognosis in patients with gastric adenocarcinoma

Xia

Kong

et al. 2016

Oncology Letters

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Abstract. Increased expression of the human DEK proto-oncogene (DEK) gene has been associated with numerous human malignancies. The DEK protein is associated with chromatin reconstruction and gene transcription, and is important in cell apoptosis. The present study aimed to elucidate the role of DEK with regard to gastric adenocarcinoma tumor progression and patient prognosis. DEK protein expression was analyzed using immunohistochemistry in 192 tumors paired with adjacent non-cancerous gastric mucosa that had been surgically resected from patients with primary gastric adenocarcinoma. The association between DEK expression and the clinicopathological characteristics of the patients was evaluated using the χ 2 test and Fisher's exact test. The survival rates of the patients were calculated using the Kaplan-Meier method. Cox analysis evaluated the association between the expression of DEK and the survival rate of the patients. The DEK protein was expressed in 84 patients with gastric adenocarcinoma (43.8%) and in 20 of the paired normal gastric mucosa tissues (11.5%). The DEK expression rate was found to be associated with tumor size (P=0.006), tumor grade (P=0.023), lymph node metastasis (P=0.018), serous invasion (P=0.026), tumor stage (P=0.001) and Ki-67 expression (P=0.003). Furthermore, patients with gastric adenocarcinoma that expressed DEK had decreased disease-free (log-rank, 16.785; P<0.0001) and overall (log-rank, 15.759; P<0.0001) survival rates compared with patients without DEK expression. Patients with late-stage gastric adenocarcinoma that expressed DEK exhibited a lower overall survival rate compared with patients without DEK expression (P=0.002). Additional analysis revealed that DEK expression was an independent prognostic factor for the prognosis of gastric adenocarcinoma (hazard ratio, 0.556; 95% confidence interval, 0.337-0.918; P=0.022). From the results of the present study, it can be concluded that the detection of DEK protein expression in gastric adenocarcinoma tissues may be important for the diagnosis and prognosis of patients, and may be a targeted therapy for the treatment of gastric adenocarcinoma.

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DEK over expression as an independent biomarker for poor prognosis in colorectal cancer

Cited by 55 publications

References 31 publications

Association of Sedentary Behavior with the Expression Levels of Biomarkers in Colorectal Cancer: Clinical Analysis of 228 Patients

Association of Sedentary Behavior with the Expression Levels of Biomarkers in Colorectal Cancer: Clinical Analysis of 228 Patients

DEK proto-oncogene is highly expressed in astrocytic tumors and regulates glioblastoma cell proliferation and apoptosis

Overexpression of DEK is an indicator of poor prognosis in patients with gastric adenocarcinoma

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