Deinoxanthin: A new carotenoid isolated from Deinococcus radiodurans

Antioxidative and Hepatoprotective Activities of Deinoxanthin-Rich Extract from <i>Deinococcus radiodurans</i> R1 against Carbon Tetrachloride-Induced Liver Injury in Mice

“…The microbe can survive a γ-ray dose of ~12 kGy, which can generate about 200 double strand breaks and 3000 single strand breaks per genome [7]. Endogenous antioxidants play an important role in the resistance capabilities of D. radiodurans, and it has been shown that the bacterium can synthesize a unique carotenoid (a non-enzymatic antioxidant), deinoxanthin [8]. In our previous study, a deinoxanthin extract derived from D. radiodurans (EDR) exhibited significantly stronger ROSscavenging activity than either lycopene or betacarotene.…”

A novel carotenoid 1,2-hydratase (CruF) from two species of the non-photosynthetic bacterium Deinococcus

“…D. radiodurans produces deinoxanthin, a unique hydroxylated carotenoid, as its major carotenoid (Lemee et al, 1997;Saito et al, 1998). Deinoxanthin was shown to have stronger reactive oxygen species (ROS) scavenging ability than lycopene and b-carotene, due to its extended conjugated double bonds and functional end groups, such as hydroxyl groups .…”

New carotenoids: Recent progress

“…Elimination of water by treatment with base was also in accordance with the properties of the 2-hydroxy-4-keto-b-end group. Although CD was measured, the stereochemistry remains unknown because no reference compound with known stereochemistry was available [9].…”