Dehydroxymethylepoxyquinomicin suppresses atopic dermatitis-like lesions in a stratum corneum-removed murine model through NF-κB inhibition

Jiang, Xiaoxue; He, Huan; Xie, Zhehui; Huang, Wen; Li, Xiaoran; Li, Xin; Ma, Jun; Umezawa, Kazuo; Zhang, Yuyang

doi:10.1080/08923973.2018.1510962

Cited by 10 publications

(7 citation statements)

References 29 publications

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“…Jiang et al [43] suggested that topical treatment of specific NF-κB inhibitor (dehydroxymethylepoxyquinomicin) improves 2,4-dinitrochlorobenzene and oxazolone-induced AD-like skin lesions. In recent research, AD symptoms were ameliorated by topical treatment of specific NF-κB inhibitor (dehydroxymethylepoxyquinomicin) in chemical irritants plus horny layer removing-induced AD murine model [44]. Thus, we presume that RSV may be helpful for us to improve AD symptoms via blocking of NF-κB.…”

Section: Discussionmentioning

confidence: 96%

Effects of Resveratrol on Thymic Stromal Lymphopoietin Expression in Mast Cells

et al. 2020

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Background and objectives: Cytokine thymic stromal lymphopoietin (TSLP) plays a pivotal role in the pathogenesis of atopic diseases such as atopic dermatitis, allergic rhinitis, and asthma. Resveratrol (RSV) exerts various pharmacological effects such as antioxidant, anti-inflammatory, neuroprotective, and anticancer. Although, it has been verified the beneficial effects of RSV on various subjects, the effect of RSV on thymic stromal lymphopoietin (TSLP) regulation has not been elucidated. Materials and Methods: Here, we examined how RSV regulates TSLP in HMC-1 cells. Enzyme-linked immunosorbent assay, real-time polymerase chain reaction, Western blotting, and calcium assay were performed to evaluate the effect of RSV. Results: TSLP production and mRNA expression were reduced by RSV. RSV down-regulated nuclear factor-κB activation, IκBα phosphorylation as well as activation of receptor-interacting protein2 and caspase-1 in HMC-1 cells. In addition, RSV treatment decreased the up-regulation of intracellular calcium in HMC-1 cells. Conclusions: These results suggest that RSV might be useful for the treatment of atopic diseases through blocking of TSLP.

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Section: Discussionmentioning

confidence: 96%

Effects of Resveratrol on Thymic Stromal Lymphopoietin Expression in Mast Cells

et al. 2020

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“…One of their functions is activation of dendritic cells to promote pro-inflammatory cytokine production of naive T helper cells [43]. In particular, keratinocyte-derived TARC, RANTES, and MDC have a major role in initiation of the inflammatory response [44,45]. Additionally, IL-8 is a cytokine that triggers chemotaxis in neutrophils and granulocytes, which are subsequently delivered toward the infected site [46].…”

Section: Discussionmentioning

confidence: 99%

Crataegus laevigata Suppresses LPS-Induced Oxidative Stress during Inflammatory Response in Human Keratinocytes by Regulating the MAPKs/AP-1, NFκB, and NFAT Signaling Pathways

et al. 2021

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Crataegus laevigata belongs to the family Rosaceae, which has been widely investigated for pharmacological effects on the circulatory and digestive systems. However, there is limited understanding about its anti-oxidative stress and anti-inflammatory effects on skin. In this study, 70% ethanol C. laevigata berry extract (CLE) was investigated on lipopolysaccharide (LPS)-stimulated keratinocytes. The LPS-induced overproduction of reactive oxygen species (ROS) was suppressed by the treatment with CLE. In response to ROS induction, the overexpression of inflammatory regulating signaling molecules including mitogen-activated protein kinases (MAPK)/activator protein-1 (AP-1), nuclear factor kappa-light-chain-enhancer of activated B cell (NF-κB), and nuclear factor of activated T-cells (NFAT) were reduced in CLE-treated human keratinocytes. Consequently, CLE significantly suppressed the mRNA levels of pro-inflammatory chemokines and interleukins in LPS-stimulated cells. Our results indicated that CLE has protective effects against LPS-induced injury in an in vitro model and is a potential alternative agent for inflammatory treatment.

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“…The NF‐ĸB inhibitor structurally related to the antibiotic epoxyquinomycin was reported to inhibit the nuclear translocation of NF‐κB RelA (p65) in TNFα‐stimulated cells without information on the nuclear transport of other SRTFs . This inhibitor also reduced the expression of IL‐1β in human THP‐1 cells challenged with titanium dioxide particles and also reduced skin inflammation in a murine model of atopic dermatitis . Ivermectin, a broad‐spectrum antiparasitic compound, was identified as an inhibitor of importin α/β nuclear import involved in the nuclear transport of some viral proteins .…”

Section: Other Nuclear Import Inhibitorsmentioning

confidence: 99%

“…184 This inhibitor also reduced the expression of IL-1β in human THP-1 cells challenged with titanium dioxide particles and also reduced skin inflammation in a murine model of atopic dermatitis. 185,186 Ivermectin, a broad-spectrum antiparasitic compound, was identified as an inhibitor of importin α/β nuclear import involved in the nuclear transport of some viral proteins. 187 Its selectivity towards individual importins α remains unclear.…”

Section: Inhibitorsmentioning

confidence: 99%

Decoding inflammation, its causes, genomic responses, and emerging countermeasures

Hawiger

Zienkiewicz

2019

Scand J Immunol

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Inflammation is the mechanism of diseases caused by microbial, autoimmune, allergic, metabolic and physical insults that produce distinct types of inflammatory responses. This aetiologic view of inflammation informs its classification based on a cause‐dependent mechanism as well as a cause‐directed therapy and prevention. The genomic era ushered in a new understanding of inflammation by highlighting the cell's nucleus as the centre of the inflammatory response. Exogenous or endogenous inflammatory insults evoke genomic responses in immune and non‐immune cells. These genomic responses depend on transcription factors, which switch on and off a myriad of inflammatory genes through their regulatory networks. We discuss the transcriptional paradigm of inflammation based on denying transcription factors’ access to the nucleus. We present two approaches that control proinflammatory signalling to the nucleus. The first approach constitutes a novel intracellular protein therapy with bioengineered physiologic suppressors of cytokine signalling. The second approach entails control of proinflammatory transcriptional cascades by targeting nuclear transport with a cell‐penetrating peptide that inhibits the expression of 23 out of the 26 mediators of inflammation along with the nine genes required for metabolic responses. We compare these emerging anti‐inflammatory countermeasures to current therapies. The transcriptional paradigm of inflammation offers nucleocentric strategies for microbial, autoimmune, metabolic, physical and other types of inflammation afflicting millions of people worldwide.

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Dehydroxymethylepoxyquinomicin suppresses atopic dermatitis-like lesions in a stratum corneum-removed murine model through NF-κB inhibition

Cited by 10 publications

References 29 publications

Effects of Resveratrol on Thymic Stromal Lymphopoietin Expression in Mast Cells

Effects of Resveratrol on Thymic Stromal Lymphopoietin Expression in Mast Cells

Crataegus laevigata Suppresses LPS-Induced Oxidative Stress during Inflammatory Response in Human Keratinocytes by Regulating the MAPKs/AP-1, NFκB, and NFAT Signaling Pathways

Decoding inflammation, its causes, genomic responses, and emerging countermeasures

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