Dehydrotestosterone Penile Stimulation in Hypospadias Surgery

Monfort, G; Lucas, Christian

doi:10.1159/000473517

Cited by 56 publications

(36 citation statements)

References 3 publications

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“…At operation, the mean plasma testosterone level was about 350 ng/dl [11]. As for topical stimulation, 2.5 [6], 5 [7] and 10% [4,8,10] testosterone creams and 5% dihydrotestosterone cream [12] were used for patients with micropenis and/or hypospadias. During topical stimulation in prepubertal boys, the highest plasma tes tosterone value varied from 35 to 390 ng/dl [4,6,8,10], In this study, the plasma testosterone levels of 13 chil dren were measured continuously.…”

Section: Discussionmentioning

confidence: 99%

“…However, a small penis and/or a shortage of foreskin to cover the penis are often obsta cles to one-stage repair. In general, androgen stimulation has been shown to be effective for micropenis and hypo spadias repair [4][5][6][7][8][9][10][11][12], But only a few reports have been made on the absorption of testosterone in children with hypospadias during topical stimulation [4,6,10]. We used testosterone ointment in 15 children with hypospa dias to produce effective penile and foreskin growth.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Use of Testosterone Ointment before Hypospadias Repair

Sakakibara¹,

Nonomura²,

Koyanagi³

et al. 1991

Urol Int

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Fifteen children, aged between 2 and 9 years old, with hypospadias (4 penile; 6 penoscrotal; 3 scrotal; 1 perineal) were administered testosterone ointment before one-stage urethroplasty. Temporary penile growth and skin enlargement were obtained in all. Side effects were negligible. The plasma testosterone level was measured before, during and after testosterone administration. During testosterone stimulation, the plasma testosterone level ranged from 30 to 190 ng/dl, and returned to the normal range a week after administration had been stopped. Primary success of hypospadias repair was obtained in 10 of 15 children (66.7%).

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Use of Testosterone Ointment before Hypospadias Repair

Sakakibara¹,

Nonomura²,

Koyanagi³

et al. 1991

Urol Int

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“…Testosterone and dihydrotestosterone cream have been used previously. [910] Monfort and Lucas used a 4-week period of local penile stimulation with daily application of 5% dihydrotestosterone cream before hypospadias repair. The author reported a mean increase in penile length and circumference by 50% of pretreatment measurements, without any lasting side effects or gonadotropin level perturbation or effect in the pubertal or post pubertal period.…”

Section: Discussionmentioning

confidence: 99%

“…The author reported a mean increase in penile length and circumference by 50% of pretreatment measurements, without any lasting side effects or gonadotropin level perturbation or effect in the pubertal or post pubertal period. [9] Local testosterone stimulation of a poly operated case of hypospadias with consequent penile enlargement and surgical success has been reported. [11] Gearhart and Jeffs reported that the result of local application of testosterone cream for temporary penile enhancement were inconsistent because of variable absorption.…”

Section: Discussionmentioning

confidence: 99%

Role of parenteral testosterone in hypospadias: A study from a teaching hospital in India

Ahmad¹,

Chana²,

Ali³

et al. 2011

Urol Ann

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Objectives:To evaluate the effect of parenteral testosterone on penile length, preputial skin and side effects in patients with hypospadias.Materials and Methods:23 patients with hypospadias were included in this study. An oily solution, each ml of which contained testosterone propionate 25 mg, and testosterone enanthate 110 mg, equivalent to 100 mg of testosterone was given deep intramuscularly 4, 3 and 2 weeks before reconstructive surgery at the dose of 2 mg/kg body weight. Increase in penile length, transverse preputial diameter, and diameter at the base of penis were noted. Basal testosterone levels were obtained before the institution of therapy and on the day of operation. In addition, side effect such as development of pubic hair and delay in bone age was noted.Results:Following parenteral testosterone administration, the mean increase in penile length, transverse preputial diameter and diameter at the base of penis was 1.35±0.40 cm (P<0.001), 1.40±0.47 cm (P<0.001), and 0.72±0.47 cm (P<0.001), respectively. Serum testosterone level after injection was well within normal range for that age. Minimal side effects were noted in form of development of fine pubic hair.Conclusion:We conclude that parenteral testosterone can be safely used to improve the surgical outcome of hypospadias repair.

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“…Thanks to the possibility of topical application of dihydrotestosterone, it is possible to optimise the size of the penis at this early age of operation [13]. In the majority of cases, the operation can be done in one step.…”

Section: Treatmentmentioning

confidence: 99%

Hypospadias

Nyarangi‐Dix

Öztürk

Hohenfellner

2008

Advances in Urology

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Objective. The great possibility of variations in the clinical presentation of hypospadia, makes its therapy challenging. This has led to the development of a number of techniques for hypospadia repair. This article assesses past and present concepts and operative techniques with the aim of broadening our understanding of this malformation. Materials and Methods. The article not only reviews hypospadia in general with its development and clinical presentation as well as historical and current concepts in hypospadiologie on the basis of available literature, but it is also based on our own clinical experience in the repair of this malformation. Results and Conclusion. The fact that there are great variations in the presentation and extent of malformations existent makes every hypospadia individual and a proposal of a universal comprehensive algorithm for hypospadia repair difficult. The Snodgrass technique has found wide popularity for the repair of distal hypospadias. As far as proximal hypospadias are concerned, their repair is more challenging because it not only involves urethroplasty, but can also, in some cases, fulfil the dimensions of a complex genital reconstruction. Due to the development of modern operating materials and an improvement in current surgical techniques, there has been a significant decrease in the complication rates. Nonetheless, there still is room and, therefore, need for further improvement in this field.

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Dehydrotestosterone Penile Stimulation in Hypospadias Surgery

Cited by 56 publications

References 3 publications

Use of Testosterone Ointment before Hypospadias Repair

Use of Testosterone Ointment before Hypospadias Repair

Role of parenteral testosterone in hypospadias: A study from a teaching hospital in India

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