Dehydrorabelomycin-1-O-α-L-rhamnopyranoside, Actinofuranone C and Further New Bioactive Secondary Metabolites from Terrestrial Streptomyces spp.

Abstract

Fiedler and Süssmuth in Tübingen (Germany) in 2004. [30] Abyssomicin I (15), a new member of this class was recently isolated from a soil-derived Streptomyces strain and exhibited inhibitory effects on tumour cell invasion with IC 50 value of 11μM. [31] Additionally, in our group, two new derivatives; ent-homoabyssomicin A (16) and B (17) with opposite stereochemistry were isolated from terrestrial Streptomyces sp. Ank 210. [32] 21 Furthermore, three new phenazine derivatives, named izumiphenazines A-C (22-24) were isolated from soil-derived Streptomyces sp. IFM 11204. Compounds B and C in combination with TRIAL (TNF-related apoptosis-inducing ligand) showed synergistic activity in sensitising TRIAL-resistant AGS cells, thereby suggesting their possible use against human gastric adenocarcinoma. [37] 31 Branimycin (32), the most complex member of nargenicin antibiotics, was isolated in our research group form terrestrial Streptomyces strain GW 60/1571. [43] It exhibited profound antibacterial activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli and particularly against Streptomyces viridochromogenes are the recent examples of this group isolated from Streptomyces sp.RI19. [47] These compounds are derivatives of promothiocin A (39) which was also isolated from a Streptomyces strain in 1994. [48] The compound 37 showed weak free radical-scavenging activity.