Dehydroepiandrosterone Supplementation Improves the Outcomes of in vitro Fertilization Cycles in Older Patients With Diminished Ovarian Reserve

Chen, San-Nung; Tsui, Kuan‐Hao; Wang, Peng-Hui; Chern, Chyi-Uei; Wen, Zhi‐Hong; Lin, Lie Chwen

doi:10.3389/fendo.2019.00800

Cited by 20 publications

(9 citation statements)

References 30 publications

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“…The existing evidence, albeit limited, collectively suggest that the POSEIDON criteria are overall useful to prognosticate reproductive outcomes among women undergoing ART, in which each group might demand specific treatment strategies ( 4 , 5 , 21 , 31 – 35 , 38 , 39 , 45 , 54 – 57 , 60 ). Thus, besides providing a counseling tool, the POSEIDON criteria may guide clinical management to optimize the FOI.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Improving Reporting of Clinical Studies Using the POSEIDON Criteria: POSORT Guidelines

Esteves¹,

Conforti

Sunkara

et al. 2021

Front. Endocrinol.

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The POSEIDON (Patient-Oriented Strategies Encompassing IndividualizeD Oocyte Number) criteria were developed to help clinicians identify and classify low-prognosis patients undergoing assisted reproductive technology (ART) and provide guidance for possible therapeutic strategies to overcome infertility. Since its introduction, the number of published studies using the POSEIDON criteria has increased steadily. However, a critical analysis of existing evidence indicates inconsistent and incomplete reporting of critical outcomes. Therefore, we developed guidelines to help researchers improve the quality of reporting in studies applying the POSEIDON criteria. We also discuss the advantages of using the POSEIDON criteria in ART clinical studies and elaborate on possible study designs and critical endpoints. Our ultimate goal is to advance the knowledge concerning the clinical use of the POSEIDON criteria to patients, clinicians, and the infertility community.

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Section: Discussionmentioning

confidence: 99%

“…After introducing the POSEIDON criteria in 2015, several studies have explored its potential benefit in clinical practice (14,(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46). However, a discrepancy has been noticed concerning the reporting of critical outcomes (36,39,40,(44)(45)(46).…”

Section: The Need To Improve the Quality Of Clinical Studies Using Thmentioning

confidence: 99%

Improving Reporting of Clinical Studies Using the POSEIDON Criteria: POSORT Guidelines

Esteves¹,

Conforti

Sunkara

et al. 2021

Front. Endocrinol.

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“…DHEA is an endogenous steroid that originates from the zona reticularis of the adrenal cortex and the ovarian theca cells in women. It is produced by the conversion of cholesterol, acting an important role in the formation of estradiol in peripheral tissues [ 9 ]. DHEA is often used in the treatment of DOR.…”

Section: Introductionmentioning

confidence: 99%

Network Pharmacology-Based Prediction and Verification of the Potential Mechanisms of He’s Yangchao Formula against Diminished Ovarian Reserve

Yang

Zhao

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Background. He’s Yangchao formula (HSYC) has been clinically proven to be effective in treating diminished ovarian reserve (DOR). However, the underlying molecular mechanisms of HSYC in DOR are unclear. Objective. This study aims to predict the underlying mechanisms of He’s Yangchao formula (HSYC) against DOR through network pharmacology strategies and verify in vivo. Methods. Systematic network pharmacology was used to speculate the bioactive components, potential targets, and the underlying mechanism of HSYC in the treatment of DOR. Then, the CTX-induced DOR mouse model was established to verify the effect of HSYC against DOR and the possible molecular mechanisms as predicted in the network pharmacology approach. Results. A total of 44 active components and 423 potential targets were obtained in HSYC. In addition, 91 targets of DOR were also screened. The identified hub genes were AKT1, ESR1, IL6, and P53. Further molecular docking showed that the four hub targets were well-bound with their corresponding compounds. In vivo experiments showed that HSYC could promote the recovery of the estrous cycle and increase the number of primordial, growing follicles and corpora lutea. Besides, The results of qRT-PCR showed HSYC could regulate the expression of AKT1, ESR1, P53, and IL6 in DOR mice. Conclusion. It was demonstrated that HSYC could increase ovarian reserves, and AKT1, ESR1, IL6, and P53 may play an essential role in this effect, which provided a new reference for the current lack of active interventions of DOR.

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“…(5) It has been suggested that DHEA supplementation may increase the number of available follicles in PORsthrough an increased serum level of insulin-like growth factor, increased follicular response to follicle stimulating hormone (FSH), shifts to aerobic metabolism (28)and improved quality of oocytes. (29) However, the e cacy of DHEA pretreatment has been controversial, with partial to reasonable clinical evidence being observed (30)(31)(32)(33)(34).Based on these ndings, we conducted a study to evaluate whether the FF metabolome differed in POR patientstreated with DHEA or not, and whether the FF metabolome may be predictive of IVF outcome. Furthermore, DHEA has immunoregulatory functions, (35) and a large-scale study of FF cytokines was conducted in parallel to reveal DHEA immunomodulatory targets.…”

Section: Introductionmentioning

confidence: 99%

Dehydroepiandrosterone Supplementation and the Impact of Follicular Fluid Metabolome and Cytokinome Profiles in Poor Ovarian Responders

Viardot-Foucault

Zhou

et al. 2022

Preprint

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Background: Poor ovarian responders (POR) are women undergoing in-vitro fertilization who respond poorly to ovarian stimulation, resulting in the retrieval of lower number of oocytes, and subsequently lower pregnancy rates. The follicular fluid (FF) provides a crucial microenvironment for the proper development of follicles and oocytes through tightly controlled metabolism and cell signaling. Conversely, dysregulated FF metabolism and cytokine production in POR could impart or reflect detrimental effects on oocytes. Androgens such as dehydroepiandrosterone (DHEA) have been proposed to alter the POR follicular microenvironment and induce metabolic changes but its utility in improving pregnancy rates remain uncertain, partially due to the unknown impact DHEA imposes on the FF metabolome and cytokine profiles. Methods: FF samples were collected from 52 POR patients who underwent IVF with DHEA supplementation (DHEA+) and without (DHEA-). The FF samples were split for profiling analyses using untargeted liquid chromatography-tandem mass spectrometry (LC-MS/MS) metabolomics and a large-scale multiplex suspension immunoassay covering 65 cytokines, chemokines and growth factors. Multivariate statistical modelling by partial least squares-discriminant regression (PLSR) analysis was performed for revealing metabolome-scale differences. Further, differential metabolite analysis between the two groups was performed by PLSR β-coefficient regression analysis and Student’s t-test. Results: Untargeted metabolomics identified 118 FF metabolites of diverse chemistries and concentrations which spanned three orders of magnitude. They include metabolic products highly associated with ovarian function – amino acids for regulating pH and osmolarity, lipids such fatty acids and cholesterols for oocyte maturation, and glucocorticoids for ovarian steroidogenesis. The FF metabolomic profiles of DHEA+ and DHEA- groups were notably distinct as classified by multivariate partial least squares regression analysis. Specifically, glycerophosphocholine, linoleic acid, progesterone, and valine were significantly lower in DHEA+ relative to DHEA-. Using the large-scale cytokine profiling assay, we observed significantly lower MCP1, IFNγ, LIF and VEGF-D levels in DHEA+ relative to DHEA. Conclusions: Collectively, our large-scale study characterized a diversity of metabolites and cytokines in the FF of POR individuals and identified several of these compounds associated DHEA supplementation.

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Dehydroepiandrosterone Supplementation Improves the Outcomes of in vitro Fertilization Cycles in Older Patients With Diminished Ovarian Reserve

Cited by 20 publications

References 30 publications

Improving Reporting of Clinical Studies Using the POSEIDON Criteria: POSORT Guidelines

Improving Reporting of Clinical Studies Using the POSEIDON Criteria: POSORT Guidelines

Network Pharmacology-Based Prediction and Verification of the Potential Mechanisms of He’s Yangchao Formula against Diminished Ovarian Reserve

Dehydroepiandrosterone Supplementation and the Impact of Follicular Fluid Metabolome and Cytokinome Profiles in Poor Ovarian Responders

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