Dehydroepiandrosterone Sulfate Reduces Acoustic Injury of the Guinea-Pig Cochlea

Abstract

Abstract. The present study was performed to determine effects of dehydroepiandrosterone sulfate (DHEAS), a neurosteroid, on acoustic injury. Albino guinea pigs were exposed to a 2 kHz pure tone of 120 or 125 dB sound pressure level for 10 min immediately after intravenous administration of DHEAS. Statistically significant improvement in the compound action potential threshold shifts and in amplitude reduction of distortion-product otoacoustic emissions was observed 1 week after the acoustic overexposure in the animals treated with DHEAS. The present results suggest that DHEAS has a protective effect against acoustic injury of the cochlea.

Local Dexamethasone Therapy Conserves Hearing in an Animal Model of Electrode Insertion Trauma-Induced Hearing Loss

“…1Y3; Table 1). This finding of hearing conservation in our animal model of cochlear implantation trauma is in agreement with other animal studies that have demonstrated a protective effect of corticosteroid treatment against development of a permanent HL induced by sound trauma (8,9) and protection against noise-induced temporary threshold shifts (10). In further support of our results are the findings that DXM treatment attenuates HL caused by aminoglycoside ototoxicity (11) and ischemia-reperfusion injury to outer hair cells (12), and protects isolated outer hair cells against the cytotoxicity of two aminoglycosides that are contained in otic drop preparations (18).…”

Emerging therapeutic interventions against noise-induced hearing loss

“…In animal models, direct administration of dexamethasone into the inner ear and intravenous administration of dehydro-epiandrosterone each lessened NIHL 76, 77 . However, the therapeutic time window was very short and another study did not confirm a positive effect of dexamethasone 78 .…”

Effects of NSAIDs on the Inner Ear: Possible Involvement in Cochlear Protection

“…Several researchers have demonstrated that glucocorticoids exhibit protective effects against cochlear injuries in animal studies [56,57,58]. Considering that glucocorticoids regulate the arachidonic cascade by inhibiting the PLA2 [59], it can be speculated that one of the protective mechanisms of glucocorticoids against cochlear injury is derived from modulation of the arachidonic cascade, although glucocorticoids are multi-functional agents.…”