Dehydroepiandrosterone sulfate deficiency in chronic fatigue syndrome.

Kuratsune, Hirohiko; Yamaguti, Kouzi; Sawada, Masaaki; Kodate, S.; Machii, Takashi; Kanakura, Y; Kitani, Teruo

doi:10.3892/ijmm.1.1.143

Cited by 27 publications

(28 citation statements)

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“…These results do not support earlier findings that higher levels of DHEA(S) are positively associated with a positive affect (32), positive well-being, and better physical and mental health (33), and negatively associated with depression (34,35) and with chronic fatigue syndrome (35)(36)(37). Nor did Grossi et al (18) report any deviations in DHEAS in participants with a high burnout score.…”

Section: Discussioncontrasting

confidence: 56%

“…It has a long biological half-time (7-10 hours) and displays a weak circadian rhythm (31). Higher levels of DHEA(S) have been shown to be positively associated with positive affect (32), positive well-being, and better physical and mental health (33), whereas lower DHEAS levels have been found in depression (34,35) and in chronic fatigue syndrome (35)(36)(37). It can thus be expected that work engagement is positively associated with DHEAS levels and negatively associated with burnout.…”

mentioning

confidence: 99%

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Do burned-out and work-engaged employees differ in the functioning of the hypothalamic-pituitary-adrenal axis?

Langelaan¹,

Bakker²,

Wb³

et al. 2006

Scand J Work Environ Health

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Section: Discussioncontrasting

confidence: 56%

mentioning

confidence: 99%

Do burned-out and work-engaged employees differ in the functioning of the hypothalamic-pituitary-adrenal axis?

Langelaan¹,

Bakker²,

Wb³

et al. 2006

Scand J Work Environ Health

View full text Add to dashboard Cite

“…Progesterone has been proposed to shorten sleep latency and to increase non-rapid-eyemovement sleep (non-REM) as well as sleep duration (157). The hypothesis that allosteric modulation of the GABA A receptor may play a significant role also in sleep disturbances in humans is backed by the finding that DHEA-S, an allosteric inhibitor of GABA A receptors, is markedly decreased in patients with chronic fatigue syndrome (241).…”

Section: E Neurosteroidsmentioning

confidence: 99%

Nongenomic Steroid Action: Controversies, Questions, and Answers

Lösel

Falkenstein

Feuring

et al. 2003

Physiological Reviews

502

321

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Lösel, Ralf M., Elisabeth Falkenstein, Martin Feuring, Armin Schultz, Hanns-Christian Tillmann, Karin Rossol-Haseroth, and Martin Wehling. Nongenomic Steroid Action: Controversies, Questions, and Answers. Physiol Rev 83: 965–1016, 2003; 10.1152/physrev.00003.2003.—Steroids may exert their action in living cells by several ways: 1) the well-known genomic pathway, involving hormone binding to cytosolic (classic) receptors and subsequent modulation of gene expression followed by protein synthesis. 2) Alternatively, pathways are operating that do not act on the genome, therefore indicating nongenomic action. Although it is comparatively easy to confirm the nongenomic nature of a particular phenomenon observed, e.g., by using inhibitors of transcription or translation, considerable controversy exists about the identity of receptors that mediate these responses. Many different approaches have been employed to answer this question, including pharmacology, knock-out animals, and numerous biochemical studies. Evidence is presented for and against both the participation of classic receptors, or proteins closely related to them, as well as for the involvement of yet poorly understood, novel membrane steroid receptors. In addition, clinical implications for a wide array of nongenomic steroid actions are outlined.

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“…When the stressor is gone, the neuroendocrine responses are normally terminated. Failure to terminate this response is observed in various conditions of an overexpressed HPA axis (4,11,17,21,25) with a subsequent attenuation of the pituitary neuroendocrine response.…”

Section: Discussionmentioning

confidence: 99%

“…Several disorders, such as obesity (21), fatigue syndrome (17), anorexia nervosa (25), bulimia nervosa (10), insomnia (8), and depression (14), have been linked to disturbances in the HPA axis and to changes in the circadian rhythms. Therefore, the objective of this study was to test the hypothesis that night eaters have an attenuated response to stress.…”

mentioning

confidence: 99%

Hypothalamic-pituitary-adrenal axis in the night eating syndrome

Birketvedt

Sundsfjord

Florholmen

2002

American Journal of Physiology-Endocrinology and Metabolism

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Birketvedt, Grethe S., Johan Sundsfjord, and Jon R. Florholmen. Hypothalamic-pituitary-adrenal axis in the night-eating syndrome. Am J Physiol Endocrinol Metab 282: E366-E369, 2002; 10.1152/ajpendo.00251.2001.-The typical neuroendocrine characteristics of the night eating syndrome have previously been described as changes in the circadian rhythm by an attenuation in the nocturnal rise of the plasma concentrations of melatonin and leptin and an increased circadian secretion of cortisol. The aim of this study was to test the hypothesis that night eaters have an overexpressed hypothalamic-pituitary-adrenal axis with an attenuated response to stress. Five female subjects with the night-eating syndrome and five sex-, age-, and weightmatched controls performed a 120-min corticotropin-releasing hormone (CRH) test (100 g iv). Blood samples were drawn intravenously for measurements of the plasma concentrations of ACTH and cortisol. The results showed that, in night eaters compared with controls, the CRH-induced ACTH and cortisol response was significantly decreased to 47 and 71%, respectively. In conclusion, disturbances in the hypothalamic-pituitary-adrenal axis with an attenuated ACTH and cortisol response to CRH were found in subjects with night-eating syndrome. circadian rhythm; cortisol; leptin; melatonin NIGHT-EATING SYNDROME, characterized by morning anorexia, evening hyperphagia, and insomnia was first described in obese subjects in 1955 by Stunkard et al. (24). It occurred during periods of stress and was associated with a poor outcome of efforts at weight reduction. In 1999 Birketvedt et al. (3) reported that nighttime awakenings were far more common among night eaters than among controls, and more than onehalf of these awakenings were associated with food intake. The typical neuroendocrine characteristics were an attenuation of nocturnal rises in secretions of melatonin and leptin and increased diurnal secretion of cortisol.Cortisol, melatonin, and leptin are regulatory hormones with typical circadian rhythms that regulate various physiological and metabolic functions (2, 23). Another main regulator is the hypothalamic-pituitaryadrenal (HPA) axis, which orchestrates several biological functions. The circadian rhythms represent the biological endocrine clock, whereas the HPA represents the stress-induced biological response. However, the interplay between these two main regulators of biological functions is not well understood. Therefore, our observations of dysregulations of circadian neuroendocrine secretions inclusive of cortisol are of special interest, as the night-eating syndrome most likely represents changes in the HPA axis.Several disorders, such as obesity (21), fatigue syndrome (17), anorexia nervosa (25), bulimia nervosa (10), insomnia (8), and depression (14), have been linked to disturbances in the HPA axis and to changes in the circadian rhythms. Therefore, the objective of this study was to test the hypothesis that night eaters have an attenuated response to stress. MATERIALS AND METHODSThis st...

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Dehydroepiandrosterone sulfate deficiency in chronic fatigue syndrome.

Cited by 27 publications

References 0 publications

Do burned-out and work-engaged employees differ in the functioning of the hypothalamic-pituitary-adrenal axis?

Do burned-out and work-engaged employees differ in the functioning of the hypothalamic-pituitary-adrenal axis?

Nongenomic Steroid Action: Controversies, Questions, and Answers

Hypothalamic-pituitary-adrenal axis in the night eating syndrome

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