Dehydroepiandrosterone-sulfate as a biomarker of senescence in male non-human primates

Circadian and age‐related changes in stress responsiveness of the adrenal cortex and erythrocyte antioxidant enzymes in female rhesus monkeys

“…A decrease of DHEAS levels with age has been noted repeatedly by us and other authors in rhesus female monkeys, in other species of monkey, and in humans [6,7,9,12,14,17,18,25,29]. The decline in DHEAS production with age leads to an increase in the ratio of molar concentration of F and DHEAS in the blood, which is generally considered an important biomarker of aging and development of aging pathology.…”

“…Primates differ essentially from rodents in hormonal regulation, and they are unique in dehydroepiandrosterone sulfate (DHEAS) secretion [10,14,17,25]. Therefore, the use of primates is preferable to the use of rodents as an experimental model in hormonal regulation and hormone replacement therapy research.…”

Adrenal androgen production in catarrhine primates and the evolution of adrenarche

“…This method of sample acquisition did not permit for a number of variables to be controlled, including time of day or season of sample collection. Adrenal androgens are secreted within circadian and ultradian rhythms, so it is possible that some variation attributable to time of day or season may affect our results (e.g., Muehlenbein et al, 2003). In addition, previous research has suggested that adrenal androgen periodicities vary among human populations (Zhao et al, 2003), and that adrenal androgen rhythms are dampened in both humans and nonhuman primates at older ages (Liu et al, 1990; Downs et al, 2008).…”

On the evolution, life history, and proximate mechanisms of human male reproductive senescence

“…89 -91 Changes in reproductive hormones in nonhuman primates in association with age suggest patterns similar to those in humans. 92,93 Information on male reproductive maturation and development among chimpanzees, our closest ape relatives, has emerged, although data from the latter portion of their life span is limited. Virtually all information on the physiology of ape senescence derives from studies of captive animals, which may differ from those in wild populations.…”