Dehydroepiandrosterone (DHEA): a fountain of youth?

Baulieu, E E

doi:10.1210/jcem.81.9.8784058

Cited by 274 publications

(93 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Biochemical pathways of androgens greatly differ between males and females. Although basal concentration of testosterone in females is low compared with males, that of DHEAS is approximately equal in males and females (Baulieu 1996). In females, androgens are for the greater part derived from the adrenal cortex and peripheral conversion from DHEA (Abraham 1974).…”

Section: Discussionmentioning

confidence: 97%

See 1 more Smart Citation

Resting serum dehydroepiandrosterone sulfate level increases after 8-week resistance training among young females

Aizawa

Akimoto

Inoue

et al. 2003

European Journal of Applied Physiology

View full text Add to dashboard Cite

This study examined changes among young females of resting serum dehydroepiandrosterone sulfate (DHEAS) concentration after an 8-week period of resistance training. Nineteen healthy untrained young females [training group: age 18.9 (0.3) years, n=10, control group: age 19.3 (1.0) years, n=9; mean (SD)] were recruited in this study. The training group participated in an 8-week resistance training program (2 days per week on nonconsecutive days). The control group did not involve in any resistance training or regular exercise during the study period. Muscular strength, anthropometry, and resting hormonal levels were measured before and after training in both groups. Serum concentrations of DHEAS, dehydroepiandrosterone (DHEA), testosterone and cortisol were measured by radioimmunoassay. Body mass (2.4%) and lean body mass (2.4%) were significantly increased in the training group ( P<0.05), but not in the control group. The training also significantly increased one-repetition maximum (1-RM) values ( P<0.05). In the training group, resting concentration of serum DHEAS significantly increased after training ( P<0.05). Percent change of DHEAS in the training group was greater than that of the control group ( P<0.05). In the training group, the change of DHEAS level was positively correlated with the change of lean body mass during the training ( r=0.61; P<0.05). Serum DHEA, testosterone and cortisol concentrations did not change in either group during the training. The dramatic increase of resting serum DHEAS concentration after training indicates that DHEAS might be an anabolic hormone marker of adaptation to resistance training among young females. Results are presented as mean (SD).

show abstract

Section: Discussionmentioning

confidence: 97%

“…Dehydroepiandrosterone (DHEA) and its conjugated sulfate (DHEAS) are steroid hormones of greatest abundance in the blood (Baulieu 1996). DHEAS is the predominant adrenal steroid in both genders.…”

Section: Introductionmentioning

confidence: 99%

Resting serum dehydroepiandrosterone sulfate level increases after 8-week resistance training among young females

Aizawa

Akimoto

Inoue

et al. 2003

European Journal of Applied Physiology

View full text Add to dashboard Cite

show abstract

“…Moreover, it has been reported that plasma levels of DHEAS are correlated with the functional ability of very old people (Berkman et al 1993;Rudman et al 1990), and that daily oral intake of 50 mg of DHEA for 12 months could have some apparent bene®cial eects (Morales et al 1994) in the elderly. Low blood levels of DHEA have also been associated with an increased insulin resistance (Coleman et al 1982;Schriock et al 1988), a greater incidence of cardiovascular disease in men (Barett-Connor et al 1986), a higher frequency of obesity (Baulieu 1996), and a raised frequency of breast cancer in women (Meikle et al 1991). DHEA is thought by some to be a youth hormone (Beaulieu 1996) since when administered to animals it has a bene®cial eect on experimental diabetes mellitus, obesity, atherosclerosis, carcinogenesis, and the immune response (Meikle et al 1991;Schneider and Reed 1985).…”

Section: Discussionmentioning

confidence: 99%

“…Indeed a reduction in plasma concentrations of total testosterone (TT; Drafta et al 1982;Gray et al 1991;Tsitouras and Bulat 1995), dehydroepiandrosterone sulfate (DHEAS; Baulieu 1996;Orentreich et al 1992), growth hormone (GH), and insulin-like growth factor I (IGF-1; Bouillanne et al 1996;Corpas et al 1993;NystroÈ m et al 1997;Rudman et al 1981) have been reported in elderly men. However, the interindividual variations in the reported concentrations of these hormones are considerable (Lamberts et al 1997).…”

Section: Introductionmentioning

confidence: 99%

Testosterone, dehydroepiandrosterone, insulin-like growth factor 1, and insulin in sedentary and physically trained aged men

Tissandier

Peres

Fiet

et al. 2001

European Journal of Applied Physiology

View full text Add to dashboard Cite

The influence of physical activity on dehydroepiandrosterone sulfate (DHEAS), total and free testosterone (TT and FT, respectively), insulin-like growth factor I (IGF-1), follicle-stimulating hormone (FSH), luteinizing hormone (LH) and insulin concentrations in aging men was investigated. Eight trained and nine sedentary men aged 60-65 years volunteered to participate in this study. Physical activity was determined during an effort test and evaluated by the measure of the maximal aerobic power (W(aer,max)). In the trained aging men, the W(aer,max) was higher than in the sedentary group of matching age [mean (SD) 206.8 (17.1) W versus 136.6 (12.3) W; P<0.0001]. The fat percentage was higher in the sedentary (n = 9) than in the trained (n = 8) group [23.9 (3.2)% versus 14.6 (3.7)%; P<0.0001]. DHEAS and IGF-1 levels were higher in trained than in sedentary subjects, respectively 2.04 (1) micromol/l versus 1.01 (0.68) micromol/l (P=0.02) and 192.1 (40.1) ng/ml versus 132.8 (31.2) ng/ml (P= 0.003). Insulin levels were higher in sedentary subjects [11.2 (3.5) mIU/l versus 7.6 (2.2) mIU/l, P=0.03]. No statistical difference was observed between both groups for FT and total TT values, FSH values and LH values. IGF-1 was correlated with W(aer,max) (r = 0.64, P = 0.003), and DHEAS was correlated with IGF-1 (r=0.59, P=0.01). We observed a relationship between fat percentage and each of the following hormones: IGF-1 (r=-0.50, P=0.03), FT (r=-0.66, P= 0.002), TT (r=-0.54, P = 0.02) and insulin (r=0.63, P=0.004). Insulin was inversely correlated with FT (r= -0.66, P=0.002) and TT (r=-0.47, P=0.05). These results suggest that regular physical activity could maintain higher DHEAS and IGF-1 and lean body mass levels in elderly men, and participate in general well being in older age.

show abstract

“…At birth, output drops to negligible amounts in both sexes and remains so until 5 -7 years of age. At the onset of adrenarche, the adrenal glands gradually resume DHEA and DHEAS production, which accelerates through puberty [14]. In young adults, the adrenal cortex secretes approximately 4 mg of DHEA and 25 mg of DHEAS per day.…”

Section: Physiology and Metabolism Of Dhea And Dheasmentioning

confidence: 99%

DHEAS as a new diagnostic tool

Leowattana

2004

Clinica Chimica Acta

View full text Add to dashboard Cite

Dehydroepiandrosterone (DHEA): a fountain of youth?

Cited by 274 publications

References 0 publications

Resting serum dehydroepiandrosterone sulfate level increases after 8-week resistance training among young females

Resting serum dehydroepiandrosterone sulfate level increases after 8-week resistance training among young females

Testosterone, dehydroepiandrosterone, insulin-like growth factor 1, and insulin in sedentary and physically trained aged men

DHEAS as a new diagnostic tool

Contact Info

Product

Resources

About