Dehydroepiandrosterone antagonizes the neurotoxic effects of corticosterone and translocation of stress-activated protein kinase 3 in hippocampal primary cultures

Kimonides, V. G.; Spillantini, M. G.; Sofroniew, Michael V.; Fawcett, James W.; Herbert, J.

doi:10.1016/s0306-4522(98)00347-9

Cited by 196 publications

(128 citation statements)

References 43 publications

Supporting

Mentioning

124

Contrasting

Unclassified

Order By: Relevance

“…In particular, DHEA appears to moderate some of the effects of cortisol, and it may even antagonize its effects in some brain areas, such as the hippocampus (Kimonides, Spillantini, Sofroniew, Fawcett, & Herbert, 1999). It is therefore important to examine the interactions between these hormones in antisocial children.…”

Section: Interactions Between Cortisol and Dhea In Antisocial Childrenmentioning

confidence: 99%

“…Because the available evidence indicates that DHEA-S may moderate some effects of cortisol (Karishma & Herbert, 2002) or even function to antagonize them (Kimonides et al, 1999), clarification of this relationship is important in understanding the biological foundations of early-onset antisocial behavior.…”

Section: Concluding Remarks On Hpa Axis Activity In Aggressive Childrenmentioning

confidence: 99%

See 1 more Smart Citation

The evidence for a neurobiological model of childhood antisocial behavior.

Goozen¹,

Fairchild²,

Snoek³

et al. 2007

Psychological Bulletin

412

393

View full text Add to dashboard Cite

Children with persistent antisocial and aggressive behavior are diagnosed as having disruptive behavior disorder. The authors review evidence that antisocial children, and especially those who persist with this behavior as they grow older, have a range of neurobiological characteristics. It is argued that serotonergic functioning and stress-regulating mechanisms are important in explaining individual differences in antisocial behavior. Moreover, low fear of punishment and physiological underactivity may predispose antisocial individuals to seek out stimulation or take risks and may help to explain poor conditioning and socialization. The authors propose a theoretical model highlighting the interplay between neurobiological deficits and cognitive and emotional functioning as mediators of the link between early adversity and antisocial behavior problems in childhood. Implications for intervention programs are discussed.

show abstract

Section: Interactions Between Cortisol and Dhea In Antisocial Childrenmentioning

confidence: 99%

Section: Concluding Remarks On Hpa Axis Activity In Aggressive Childrenmentioning

confidence: 99%

The evidence for a neurobiological model of childhood antisocial behavior.

Goozen¹,

Fairchild²,

Snoek³

et al. 2007

Psychological Bulletin

412

393

View full text Add to dashboard Cite

show abstract

“…Overall, it is still possible that the endocrine findings are not related to a diagnostic specificity, and the elevated cortisol/DHEA(S) ratios in schizophrenia patients may be associated with impaired stress-response (Wolf and Kirschbaum, 1999;Boudarene and Legros, 2002;Kimonides et al, 1999) and may lead to dysregulated neurotransmission (Akwa and Baulieu, 2000), resulting in chronic and progressive deterioration in cognitive, emotional, and psychosocial functions (Wen et al, 2001;Johnson et al, 2002). Indeed, clinical investigations produced evidence of the involvement of neuroactive steroids in conditions such as fatigue during pregnancy, premenstrual syndrome, postpartum depression, epilepsy, dementia, depressive, and anxiety disorders (Stoffel-Wagner, 2001;Pisua and Serra, 2004).…”

Section: Commentmentioning

confidence: 99%

Cortisol/Dehydroepiandrosterone Ratio and Responses to Antipsychotic Treatment in Schizophrenia

Ritsner

Gibel

Maayan

et al. 2005

Neuropsychopharmacol

View full text Add to dashboard Cite

Dehydroepiandrosterone (DHEA) or their sulfate conjugate (DHEAS) (together abbreviated DHEA(S)) exert multiple effects in the central nervous system, and may be involved in the pathophysiological processes in schizophrenia. This prospective study aimed to investigate whether serum cortisol/DHEA(S) molar ratios are associated with response to antipsychotic treatment during the exacerbation of schizophrenia. Serum DHEA(S) and cortisol were determined at baseline, and 2 and 4 weeks later for 43 medicated schizophrenia inpatients with acute exacerbation. The patients were treated with stable doses of antipsychotic agents up to 2 weeks prior to entering the study and for the 4-week duration of the study after which they were classified as either responders or nonresponders to treatment. Findings suggest that responders had significantly higher serum cortisol levels and cortisol/DHEA(S) ratios compared with nonresponders. These differences remained significant at three time points controlling for gender, age, severity of symptoms and emotional distress, benzodiazepines, type or dosage of antipsychotic agents, and background variables. The logistic regression model shows advantages of both cortisol/DHEA(S) molar ratios vs serum cortisol and DHEA(S) concentrations for prediction of responsivity to antipsychotic treatment. No significant canonical correlations were observed between changes from baseline through end-of-study in hormonal values and severity of symptoms and emotional distress among responders and nonresponders. Thus, these data provide evidence that elevated serum cortisol and cortisol/DHEA(S) ratios may serve as markers of biological mechanisms that are involved in responsivity of schizophrenia patients to antipsychotic treatment.

show abstract

“…Whereas high cortisol has catabolic properties, DHEA and its sulfate form DHEAS have been found to possess anabolic, neuroprotective and antiglucocorticoid effects, showing neurogenerative effects in the hippocampus (Karishma and Herbert, 2002) and protection against the neurotoxic effects of cortisol in studies in rodents (Kaminska et al, 2000;Kimonides et al, 1998Kimonides et al, , 1999. This may contribute to an upregulation of HPA-axis responses as well as mitigate possible deleterious effects of high cortisol levels on the brain in PTSD (Rasmusson et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

The role of acute cortisol and DHEAS in predicting acute and chronic PTSD symptoms

Mouthaan

Sijbrandij²,

Luitse

et al. 2014

Psychoneuroendocrinology

View full text Add to dashboard Cite

SummaryBackground: Decreased activation of the hypothalamus-pituitary-adrenal (HPA) axis in response to stress is suspected to be a vulnerability factor for posttraumatic stress disorder (PTSD). Previous studies showed inconsistent findings regarding the role of cortisol in predicting PTSD. In addition, no prospective studies have examined the role of dehydroepiandrosterone (DHEA), or its sulfate form DHEAS, and the cortisol-to-DHEA(S) ratio in predicting PTSD. In this study, we tested whether acute plasma cortisol, DHEAS and the cortisol-to-DHEAS ratio predicted PTSD symptoms at 6 weeks and 6 months post-trauma. Methods: Blood samples of 397 adult level-1 trauma center patients, taken at the trauma resuscitation room within hours after the injury, were analyzed for cortisol and DHEAS levels. PTSD symptoms were assessed at 6 weeks and 6 months post-trauma with the Clinician Administered PTSD Scale. Results: Multivariate linear regression analyses showed that lower cortisol predicted PTSD symptoms at both 6 weeks and 6 months, controlling for age, gender, time of blood sampling, injury, trauma history, and admission to intensive care. Higher DHEAS and a smaller cortisol-to-DHEAS ratio predicted PTSD symptoms at 6 weeks, but not after controlling for the same variables, and not at 6 months. Conclusions: Our study provides important new evidence on the crucial role of the HPA-axis in response to trauma by showing that acute cortisol and DHEAS levels predict PTSD symptoms in survivors of recent trauma. #

show abstract

Dehydroepiandrosterone antagonizes the neurotoxic effects of corticosterone and translocation of stress-activated protein kinase 3 in hippocampal primary cultures

Cited by 196 publications

References 43 publications

The evidence for a neurobiological model of childhood antisocial behavior.

The evidence for a neurobiological model of childhood antisocial behavior.

Cortisol/Dehydroepiandrosterone Ratio and Responses to Antipsychotic Treatment in Schizophrenia

The role of acute cortisol and DHEAS in predicting acute and chronic PTSD symptoms

Contact Info

Product

Resources

About