Dehydroepiandrosterone and cortisol/dehydroepiandrosterone ratios in dairy cattle with postpartum metritis

Gundlach, Neele Hendrika; Feldmann, M.; Gundelach, Yasmin; Gil, Marcelo Araujo; Siebert, Ursula; Hoedemaker, Martina; Schmicke, Marion

doi:10.1016/j.rvsc.2017.09.024

Cited by 8 publications

(7 citation statements)

References 17 publications

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“…As a matter of fact, a significant increase in DHEA-S was observed in septic compared with healthy and sick non-septic newborn foals (Dembek et al, 2017), and plasma DHEA concentrations were higher in foal affected by Neonatal maladjustment syndrome or other neonatal pathologies (Aleman et al, 2013). Also in postpartum dairy cows, plasma DHEA concentrations were higher in cows with metritis, and it was hypothesized that DHEA could represent an anti-inflammatory signal during prolonged inflammation, and a biomarker or prognostic indicator for evaluating disease severity (Gundlach et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

“…A significant increase in DHEA-S was observed in septic compared with healthy and sick non-septic newborn foals (Dembek et al, 2017), and plasma DHEA concentrations were higher in foal affected by neonatal maladjustment syndrome or other neonatal pathologies (Aleman et al, 2013). However, associations between plasma DHEA concentrations and inflammation have been found in other ungulate species, such as the postpartum dairy cows with metritis, where it was hypothesized that DHEA may be an anti-inflammatory signal during prolonged inflammation, and a biomarker or prognostic indicator for evaluating disease severity (Gundlach et al, 2017). A more accurate evaluation of the HPA axis activation in stressful or inflammatory situations may be achieved by analyzing the cortisol/DHEA ratio.…”

Section: Introductionmentioning

confidence: 99%

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Relationship between postpartum uterine involution and biomarkers of inflammation and oxidative stress in clinically healthy mares (Equus caballus)

Falomo

Rossi

et al. 2020

Heliyon

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To test the hypothesis that delayed/impaired uterine involution could be associated with oxinflammation, we studied the progression of the uterine involution in association with some biomarkers of inflammation and oxidative stress in clinically healthy mares (N ¼ 26) during early postpartum. The examination of the reproductive tract was performed on Days 7 and 21 after foaling. Uterine involution was assessed considering: a) the increase of the gravid uterine horn diameter (GUHD) compared with diameter recorded before pregnancy during the previous breeding season; b) the level of endometrial edema (EE); c) the degree of accumulation of intrauterine fluid (IUFA); d) the status of the cervix (CS). Inflammation and oxidative stress were studied by measuring serum amyloid A (SAA), cortisol, DHEA, AOPP, protein carbonyl groups, malondialdheyde (MDA) and thiols in plasma on Days 7 and 21. By Day 21 after parturition, a significant improvement (P < 0.01) was observed for GUHD and EE; while IUFA increased in six animals. Plasma SAA and DHEA concentrations were higher when the clinical parameters indicated a lower degree of uterine involution. On Day 7, the cortisol/DHEA ratio was lower in animals with higher degree of EE. Plasma AOPP and MDA concentrations were significantly lower (P < 0.05) in animals with the lower GUHD. On Day 21, plasma MDA concentrations were significantly lower (P < 0.05) in animals with the lower IUFA. Our data suggest that a mild condition of inflammation and oxidative stress occur in mares with delayed/impaired uterine involution.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Relationship between postpartum uterine involution and biomarkers of inflammation and oxidative stress in clinically healthy mares (Equus caballus)

Falomo

Rossi

et al. 2020

Heliyon

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“…(2017) observed increased plasma DHEA in cows kept in overcrowded conditions during the last month before parturition. Cows with metritis displayed higher plasma DHEA concentrations only in subjects with low white blood cells count (Gundlach et al ., 2017).…”

Section: Stress Biomarkersmentioning

confidence: 99%

Biomarkers of fitness and welfare in dairy animals: healthy living

Almeida

Zachut

Hernández-Castellano

et al. 2019

Journal of Dairy Research

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Increased animal productivity has reduced animal fitness, resulting in increased susceptibility to infectious and metabolic diseases, locomotion problems and subfertility. Future animal breeding strategies should focus on balancing high production levels with health status monitoring and improved welfare. Additionally, understanding how animals interact with their internal and external environment is essential for improving health, fitness, and welfare. In this context, the continuous validation of existing biomarkers and the discovery and field implementation of new biomarkers will enable us to understand the specific physiological process and regulatory mechanisms used by the organism to adapt to different environmental conditions. Thus, biomarkers may be used to monitor welfare and improve management and breeding strategies. In this article, we describe major achievements in the establishment of biomarkers in dairy cows and small ruminants. This review mainly focuses on the physiological biomarkers used to monitor animal responses to, and recovery from, environmental perturbations. We highlight future avenues for research in this field and present a timely positioning document to the scientific community.

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“…The latter displayed also lower cortisol/DHEA ratio than healthy cows. Authors concluded that DHEA and the cortisol/DHEA ratio could represent an anti-inflammatory signal during prolonged inflammation and a putative prognostic biomarker for evaluating disease severity (105). It is worth noting that inflammatory events can have long term effects on ovarian steroidogenesis in cattle.…”

Section: Immuno-stressors In Domestic Animals "In Vivo"mentioning

confidence: 99%

Do Dehydroepiandrosterone (DHEA) and Its Sulfate (DHEAS) Play a Role in the Stress Response in Domestic Animals?

et al. 2020

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In animal husbandry, stress is often associated with poor health and welfare. Stress occurs when a physiological control system detects a state of real or presumptive threat to the animal's homeostasis or a failure to control a fitness-critical variable. The definition of stress has mostly relied on glucocorticoids measurement, even though glucocorticoids represent one stress-response system, the hypothalamus-pituitary-adrenocortical axis, which is not precise enough as it is also related to metabolic regulation and activated in non-stressful situations (pleasure, excitement, and arousal). The mammal adrenal can synthesize the androgenic steroid dehydroepiandrosterone (DHEA) and its sulfate metabolite (DHEAS), which have been associated to the stress response in several studies performed mostly in humans and laboratory animals. Although the functions of these steroids are not fully understood, available data suggest their antagonistic effects on glucocorticoids and, in humans, their secretion is affected by stress. This review explores the scientific literature on DHEA and DHEAS release in domestic animals in response to stressors of different nature (inflammatory, physical, or social) and duration, and the extra-adrenal contribution to circulating DHEA. Then, the potential use of DHEA in conjunction with cortisol to improve the definition of the stress phenotype in farmed animals is discussed. Although the focus of this review is on farmed animals, examples from other species are reported when available.

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Dehydroepiandrosterone and cortisol/dehydroepiandrosterone ratios in dairy cattle with postpartum metritis

Cited by 8 publications

References 17 publications

Relationship between postpartum uterine involution and biomarkers of inflammation and oxidative stress in clinically healthy mares (Equus caballus)

Relationship between postpartum uterine involution and biomarkers of inflammation and oxidative stress in clinically healthy mares (Equus caballus)

Biomarkers of fitness and welfare in dairy animals: healthy living

Do Dehydroepiandrosterone (DHEA) and Its Sulfate (DHEAS) Play a Role in the Stress Response in Domestic Animals?

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