Dehydration of mildronate dihydrate: a study of structural transformations and kinetics

Effect of Experimental and Sample Factors on Dehydration Kinetics of Mildronate Dihydrate: Mechanism of Dehydration and Determination of Kinetic Parameters

“…It is visible that the dehydration of fractions with particle size below 150 μm was best described by the one‐dimensional phase boundary model R1, whereas that of fractions with particle size above 350 μm was best described by the two‐dimensional phase boundary model R2. This was consistent with our previous work . The other examined experimental and sample factors did not change the dehydration kinetic model.…”

“…This cannot be explained by the higher temperature, because dehydration of the 350–700 μm fraction was examined at the same conditions as the fractions with smaller particle size. As already mentioned, decrease of the average E a for these two fractions was associated with the increased diffusion of water out of the particles . Thus, it was possible that the diffusion effect slightly increased during the dehydration, and in this way E a decreased by increasing α, as shown in Figure a.…”

“…Powder X‐ray diffraction was used to determine that AP was obtained as a dehydration product. However, in samples where the dehydration continued after the melting/peritectic decomposition point, MH was also detected, even though its formation was not associated with direct dehydration of the DH (see SI).…”

“…Water molecules in the DH and MH are situated in structural channels, whereas in the structure of the AP, empty channels are present . Dehydration of the DH is a single‐step process resulting directly in the formation of AP . The effects of some sample and experimental factors on the dehydration kinetic parameters have already been reported.…”

“…The effects of some sample and experimental factors on the dehydration kinetic parameters have already been reported. However, only limited number of factors were studied for one sample in isothermal mode …”