Dehalobase: A Database of Dehalogenase and other Allied Enzymes

Satpathy, Raghunath; Konkimalla, Venkata Sai Badireenath; Ratha, Jagnyeswar

doi:10.5958/0975-8089.2015.00004.4

Cited by 3 publications

(1 citation statement)

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“…XAMPP contains an integrated and cross-feature rich platform and is most commonly used for Web development. The acronym of the XAMPP tool is X (cross-platform), A (Apache server language), M (MySQL), P (PHP), and other P (PERL language) that facilitates the database creation [24]. MySQL was used to design the backend of the database, which is implemented in relational database management systems (RDBMS) throughout the world [25].…”

Section: Development Of Database Development Of Databasementioning

confidence: 99%

Development of a database of RNA helicase inhibitors (VHIMDB) of pathogenic viruses and in silico screening for the potential drug molecules

Satpathy

Acharya

2022

The EuroBiotech Journal

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The pathogenic RNA virus that infects human beings contains the RNA helicase enzyme, responsible for the replication of the viral genome. The enzyme is used as a suitable target against which the drug molecule acts. Therefore, the identification and proposal the novel compounds that can be targeted toward the helicase enzymes to stop the functioning of the enzyme is desirable. Although many viral helicase inhibitor molecules have been identified, still yet no unique database is available for these compounds. This research work envisages developing a curated database of RNA helicase inhibitors. The database contains in total of 353 entries that are computationally predicted and experimentally verified RNA helicase inhibitors. The database contains information like compound name, chemical properties, chemical format, and name of the target virus to which it acts against it with a user-friendly menu-driven search engine. Presently, the database is freely available at: https://vhimdb.rsatpathy.in/. Further, in silico screening of the whole database by drug-likeness and toxicity resulted in 14 potential drug molecules. The selected molecules were analyzed for their effectiveness in binding by using molecular docking score and interaction with the helicase enzymes of three categories of pathogenic viruses (SARS-CoV-2, SARS-CoV, and MERS-CoV).

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Section: Development Of Database Development Of Databasementioning

confidence: 99%

Development of a database of RNA helicase inhibitors (VHIMDB) of pathogenic viruses and in silico screening for the potential drug molecules

Satpathy

Acharya

2022

The EuroBiotech Journal

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Microbial dehalogenation: 3-chloropropanoic acid (3-CPA) degradation as a case study

2017

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Application of Dehalogenase Enzymes in Bioremediation of Halogenated Pollutants

Satpathy¹

2021

Advances in Environmental Engineering and Green Technologies

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The halogenated hydrocarbons have been widely used by human beings. They are xenobiotic and toxic. The microbes having a specific group of hydrolase enzymes, known as dehalogenases, that actually break the carbon-halogen bonds of the halogenated substances and subsequently convert them into their non-toxic forms. In this chapter, the categories of dehalogenase enzymes possessed by microorganisms are narrated. The overall source, mechanism of catalysis, and structural aspects of the haloalkane dehalogenase enzymes have been discussed with special focus to the bioremediation of 1, 2 dichloroethane.

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Dehalobase: A Database of Dehalogenase and other Allied Enzymes

Cited by 3 publications

References 0 publications

Development of a database of RNA helicase inhibitors (VHIMDB) of pathogenic viruses and in silico screening for the potential drug molecules

Development of a database of RNA helicase inhibitors (VHIMDB) of pathogenic viruses and in silico screening for the potential drug molecules

Microbial dehalogenation: 3-chloropropanoic acid (3-CPA) degradation as a case study

Application of Dehalogenase Enzymes in Bioremediation of Halogenated Pollutants

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