Deguelin targets multiple oncogenic signaling pathways to combat human malignancies

Tuli, Hardeep Singh; Mittal, Sonam; Loka, Mariam; Aggarwal, Vaishali; Aggarwal, Diwakar; Masurkar, Akshara; Kaur, Ginpreet; Varol, Mehmet; Sak, Katrin; Kumar, Manoj; Sethi, Gautam; Bishayee, Anupam

doi:10.1016/j.phrs.2021.105487

Cited by 21 publications

(17 citation statements)

References 101 publications

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“…One of the first molecules analyzed using zebrafish as experimental model was deguelin [ 57 ], a derivative of rotenone and part of the flavonoid family, whose potential chemopreventive activities against several types of cancers have been shown [ 58 ]. Indeed, the therapeutic efficacy of deguelin was clearly demonstrated in aerodigestive tract cancer, non-small cell lung cancer (NSCLC) and head and neck squamous cell carcinoma (HNSCC), where it inhibited hypoxia inducing factor (HIF)-1a expression at both translational and post-translational levels and suppressed vascular endothelial growth factor (VEGF), hence the angiogenic process.…”

Section: Effects Of Flavonoids Employing Zebrafish As Experimental Modelmentioning

confidence: 99%

Zebrafish as a Useful Model to Study Oxidative Stress-Linked Disorders: Focus on Flavonoids

et al. 2021

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The zebrafish is considered one of the most versatile experimental animal models. The transparency of the embryos, the small size, the rapid development and the homology with higher vertebrates have made the zebrafish a valuable model also for drug screening. Its use is closely related for the determination of bioactivity, toxicity and off-target side effects of novel drug candidates, which also allows a thorough evaluation of new targets; thus, it may represent a suitable model for drug screening and the optimization of novel candidates. Flavonoids are polyphenolic compounds widely present in fruits, vegetables and cereals. Polyphenols are important for both plants and humans, considering their involvement in defense mechanisms, particularly against oxidative stress. They protect plants from biotic and abiotic stressors and prevent or treat oxidative-based human diseases. For these reasons, polyphenols are used as nutraceuticals, functional foods and supplements by the pharmaceutical industry. Therefore, the most relevant findings on zebrafish as a useful experimental model to study oxidative stress-linked disorders, focusing on the biological activities of flavonoids, are here summarized and reviewed.

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Section: Effects Of Flavonoids Employing Zebrafish As Experimental Modelmentioning

confidence: 99%

Zebrafish as a Useful Model to Study Oxidative Stress-Linked Disorders: Focus on Flavonoids

et al. 2021

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“…Graveospene A, isolated from the leaves of Casearia graveolens , is a new clerodane diterpenoid that has been reported to induce apoptosis in A549 cells with an IC 50 value of 1.9 μM by inducing cell cycle arrest in phase G0/G1 [ 76 ]. Deguelin, a protein kinase B (AKT) kinase inhibitor, is isolated from the African plant Mundulea sericea (Leguminosae) and is commonly used to inhibit the growth of several types of human cancer cell lines [ 77 ]. Deguelin promoted the phosphorylation of myeloid cell leukemia sequence-1 (Mcl-1) protein and induced the inhibition of the wildtype and mutated epidermal growth factor receptor (EGFR)-Akt signaling pathway, which resulted in activation of downstream GSK3β/FBW7 and profound anti-NSCLC activity with no obvious side effects in vivo [ 78 ].…”

Section: Natural Products As Monotherapy For the Treatment Of Lung Cancermentioning

confidence: 99%

Natural Products, Alone or in Combination with FDA-Approved Drugs, to Treat COVID-19 and Lung Cancer

Yang

Wang

2021

Biomedicines

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As a public health emergency of international concern, the highly contagious coronavirus disease 2019 (COVID-19) pandemic has been identified as a severe threat to the lives of billions of individuals. Lung cancer, a malignant tumor with the highest mortality rate, has brought significant challenges to both human health and economic development. Natural products may play a pivotal role in treating lung diseases. We reviewed published studies relating to natural products, used alone or in combination with US Food and Drug Administration-approved drugs, active against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and lung cancer from 1 January 2020 to 31 May 2021. A wide range of natural products can be considered promising anti-COVID-19 or anti-lung cancer agents have gained widespread attention, including natural products as monotherapy for the treatment of SARS-CoV-2 (ginkgolic acid, shiraiachrome A, resveratrol, and baicalein) or lung cancer (daurisoline, graveospene A, deguelin, and erianin) or in combination with FDA-approved anti-SARS-CoV-2 agents (cepharanthine plus nelfinavir, linoleic acid plus remdesivir) and anti-lung cancer agents (curcumin and cisplatin, celastrol and gefitinib). Natural products have demonstrated potential value and with the assistance of nanotechnology, combination drug therapies, and the codrug strategy, this “natural remedy” could serve as a starting point for further drug development in treating these lung diseases.

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“…Uncontrolled growths of tumors are found to show metastasis and spreading from one site to another. There have been a variety of cancer treatment strategies are available such as chemotherapy, radiotherapy, and surgical procedures [93][94][95] . Nurses are found to play an important role during cancer treatment of patients.…”

Section: Gynecologic Oncologymentioning

confidence: 99%

Role of Nurses in the Management of Common Gynecological Diseases: Recent Advances

Tuli

2021

JCNR

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In recent years the role of the specialist nurse with respect to gynecology and women’s health has gained significant importance. The advancement in the nursing practice has provided an insight to interact with patients to explore their history. Such hysteroscopy procedures may not only give a better feel to the patient but also explore the need for doctor treatment. The review updates about the ongoing advances in the field of nursing science to upgrade the life of patients with gynecological diseases. Evidence has suggested the promising role of nurses to motivate patients with improved health after the treatment. The present review will cover the various health issues of women including menstrual dysfunction, fertility, and management of pregnancy’s termination, uro-gynecological issues, and gyne-oncology, etc. The role of nurses during the above health issue will be discussed via various procedures. Therefore, the present review will conclude the significant importance of nurses in women’s health issues to sustain happiness and to strengthen the need to bring advances in the curriculum of nurses to full fill the requirement of medical staff.

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Deguelin targets multiple oncogenic signaling pathways to combat human malignancies

Cited by 21 publications

References 101 publications

Zebrafish as a Useful Model to Study Oxidative Stress-Linked Disorders: Focus on Flavonoids

Zebrafish as a Useful Model to Study Oxidative Stress-Linked Disorders: Focus on Flavonoids

Natural Products, Alone or in Combination with FDA-Approved Drugs, to Treat COVID-19 and Lung Cancer

Role of Nurses in the Management of Common Gynecological Diseases: Recent Advances

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