Degrees of separation: A quantitative neuroimaging meta-analysis investigating self-specificity and shared neural activation between self- and other-reflection

Murray, Ryan J.; Schaer, Marie; Debbané, Martin

doi:10.1016/j.neubiorev.2011.12.013

Cited by 278 publications

(286 citation statements)

References 115 publications

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“…In their single-neuron study, the authors demonstrated that images of experimenters elicited greater amygdala FR than family and self. While family members and self both possess affective relevance (Murray et al, 2012), experimenters may indeed bear a level of self-relevance as well, as they serve as the proxy caretakers of these patients during their perioperative period. Novelty detection, however, does appear to be quite prominent nonetheless, as we see equal neuronal firing in the amygdala in response to strangers as to celebrities, family and self.…”

Section: Affective Processingmentioning

confidence: 99%

The functional profile of the human amygdala in affective processing: Insights from intracranial recordings

Murray

Brosch

Sander

2014

Cortex

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t r a c tThe amygdala is suggested to serve as a key structure in the emotional brain, implicated in diverse affective processes. Still, the bulk of existing neuroscientific investigations of the amygdala relies on conventional neuroimaging techniques such as fMRI, which are very useful but subject to limitations. These limitations are particular to their temporal resolution, but also to their spatial precision at a very fine-grained level. Here, we review studies investigating the functional profile of the human amygdala using intracranial electroencephalography (iEEG), an invasive technique with high temporal and spatial precision. We conducted a systematic literature review of 47 iEEG studies investigating the human amygdala, and we focus on two content-related domains and one process-related domain: (1) memory formation and retrieval; (2) affective processing; and (3) latency components. This review reveals the human amygdala to engage in invariant semantic encoding and recognition of specific objects and individuals, independent of context or visuospatial attributes, and to discriminate between familiar and novel stimuli. The review highlights the amygdala's role in emotion processing witnessed in differential treatment of social-affective facial cues, differential neuronal firing to relevant novel stimuli, and habituation to familiar affective stimuli. Overall, the review suggests the amygdala plays a key role in the processing of affective relevance. Finally, this review delineates effects on amygdala neuronal activity into three time latency windows (post-stimulus onset). The early window (~50e290 msec) subsumes effects respective to exogenous stimulus-driven affective processing of faces and emotion. The intermediate window (~270e470 msec) comprises effects related to explicit attention to novel task-relevant stimuli, irrespective of sensory modality. The late window (~600e1400 msec) subsumes effects from tasks soliciting semantic associations and working memory during affective processing. We juxtapose these iEEG data with current clinical topics relevant to amygdala activation and propose avenues for future investigation of the amygdala using iEEG methods.© 2014 Elsevier Ltd. All rights reserved.* Corresponding author. Campus Biotech, CISA e University of Geneva, Case Postale 60, CH e 1211 Gen eve 20, Switzerland. E-mail address: ryan.murray@unige.ch (R.J. Murray).Available online at www.sciencedirect.com ScienceDirectJournal homepage: www.elsevier.com/locate/cortex c o r t e x 6 0 ( 2 0 1 4 ) 1 0 e3 3 http://dx

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Section: Affective Processingmentioning

confidence: 99%

The functional profile of the human amygdala in affective processing: Insights from intracranial recordings

Murray

Brosch

Sander

2014

Cortex

Self Cite

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“…The self-reflection network was defined based on previous meta-analyses [Murray et al, 2012;van der Meer et al, 2010] and involves the dorsal and ventral medial prefrontal cortex (dmPFC and vmPFC), inferior parietal lobule (IPL), posterior cingulate cortex (PCC) and insula. These regions have been implicated in grey matter deficiencies related to poor insight (summarized in [Morgan et al, 2010]).…”

Section: Introductionmentioning

confidence: 99%

“…Liemburg et al [2012] investigated functional connectivity in schizophrenia in relation to impaired insight and reported decreased connectivity of the anterior cingulate cortex (ACC) with both the anterior and posterior parts of the default mode network (DMN). Even though brain connectivity was studied here in the absence of a particular task (during the resting state), all of the implicated regions are involved in reflective processing [Gillihan and Farah, 2005;Murray et al, 2012]. In addition, the investigation of functional brain connectivity in patients during an actual task, ideally judging personal adjectives (reflective processing), would be essential to investigate the neural correlates of impaired insight.…”

Section: Introductionmentioning

confidence: 99%

Insight and psychosis: Functional and anatomical brain connectivity and self‐reflection in Schizophrenia

Ćurčić‐Blake

Meer

Pijnenborg

et al. 2015

Human Brain Mapping

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Impaired insight into illness, associated with worse treatment outcome, is common in schizophrenia. Insight has been related to the self-reflective processing, centred on the medial frontal cortex. We hypothesized that anatomical and functional routes to and from the ventromedial prefrontal cortex (vmPFC) would differ in patients according to their degree of impaired insight. Forty-five schizophrenia patients and 19 healthy subjects performed a self-reflection task during fMRI, and underwent diffusion tensor imaging. Using dynamic causal modelling we observed increased effective connectivity from the posterior cingulate cortex (PCC), inferior parietal lobule (IPL), and dorsal mPFC (dmPFC) towards the vmPFC with poorer insight and decrease from vmPFC to the IPL. Stronger connectivity from the PCC to vmPFC during judgment of traits related to self was associated with poorer insight. We found small-scale significant changes in white matter integrity associated with clinical insight. Self-reflection may be influenced by synaptic changes that lead to the observed alterations in functional connectivity accompanied by the small-scale but measurable alterations in anatomical connections. Our findings may point to a neural compensatory response to an impairment of connectivity between self-processing regions. Similarly, the observed hyper-connectivity might be a primary deficit linked to inefficiency in the component cognitive processes that lead to impaired insight. We suggest that the stronger cognitive demands placed on patients with poor insight is reflected in increased effective connectivity during the task in this study.

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“…From a social cognition perspective, the VMPFC has been implicated in the representation and evaluation of others perceived to be similar to the self (Delgado et al, 2016). Specifically, activation of the VMPFC was found during evaluations of other people when they were emotionally close or shared traits with the self (Mitchell, Macrae, & Banaji, 2006;Murray, Schaer, & Debbane, 2012).…”

Section: Discussionmentioning

confidence: 99%

Aversive smell associations shape social judgment

Homan

Yuan

Brosch

et al. 2017

Neurobiology of Learning and Memory

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a b s t r a c tOnce associating another person with an unpleasant smell, how do we perceive and judge this person from that moment on? Here, we used aversive olfactory conditioning followed by a social attribution task during functional magnetic resonance imaging to address this question. After conditioning, where one of two faces was repeatedly paired with an aversive smell, the participants reported negative affect when viewing the smell-conditioned but not the neutral face. When subsequently confronted with the smell-conditioned face (without any smell), the participants tended to judge both positive and negative behaviors as indicative of personality traits rather than related to the situation. This effect was predicted by the degree of the preceding olfactory evaluative conditioning. Whole brain analysis of stimulus by stage interaction indicated differential activation of the ventromedial prefrontal cortex and right angular gyrus to the conditioned versus the neutral person during the attribution phase only. These results suggest that negative smell associations do not simply induce a negative perception of the target person but rather bias the attribution style towards trait attributions. The fact that this bias was evident regardless of behavior valence suggests it may reflect enhanced psychological distance. Thus, the known observation of social rejection triggered by aversive smell may be driven by a shift in social attribution style.

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Degrees of separation: A quantitative neuroimaging meta-analysis investigating self-specificity and shared neural activation between self- and other-reflection

Cited by 278 publications

References 115 publications

The functional profile of the human amygdala in affective processing: Insights from intracranial recordings

The functional profile of the human amygdala in affective processing: Insights from intracranial recordings

Insight and psychosis: Functional and anatomical brain connectivity and self‐reflection in Schizophrenia

Aversive smell associations shape social judgment

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