Degree of diffuse fibrosis measured by MRI correlates with LV remodelling in childhood cancer survivors after anthracycline chemotherapy

Expert Consensus for Multimodality Imaging Evaluation of Adult Patients during and after Cancer Therapy: A Report from the American Society of Echocardiography and the European Association of Cardiovascular Imaging

“…228,229 One recent study in a small cohort of 13 patients after anthracycline therapy and with normal LV function demonstrated no correlation between anthracycline dose and myocardial fibrosis, though there was a relationship with increased LV volume. 230 Using this technique, Neilan et al 231 recently reported increased extracellular volume as a surrogate of myocardial fibrosis in 42 patients treated with anthracyclines, compared with ageand gender-matched controls. A positive association was found between the extracellular volume and the left atrial volume, and a negative association was found between the extracellular volume and LV diastolic function.…”

T 1 Mapping With Cardiovascular MRI Is Highly Sensitive for Fabry Disease Independent of Hypertrophy and Sex

“…T 1 mapping of the left ventricle was performed in a basal and midventricular short-axis slice using the SAturation-recovery singleSHot Acquisition (SASHA) steady-state-free precession pulse sequence. [13][14][15] For SASHA acquisitions, single-shot images were acquired during diastasis in sequential heartbeats, with a single nonsaturation image followed by 9 images with saturation recovery times (TS) spanning the interval from the QRS to diastasis. Typical pulse sequence parameters: TE, 1.39 ms; repetition time, 2.78 ms; flip angle, 70°; 8-mm slice thickness; matrix size, 192×108; field of view, 360×270 mm; 75% phase partial Fourier; and 9 TS values between 120 and 900 ms for a heart rate of 60 bpm.…”

Strategies for Early Detection of Cardiotoxicities from Anticancer Therapy in Adults: Evolving Imaging Techniques and Emerging Serum Biomarkers

“…One group studied 30 children at least 2 years postanthracycline therapy and found an association between increased ECV, decreased exercise capacity and decreased mass to LV volume ratio [52,53] despite preserved systolic function. Forty-two patients who had previously received anthracyclines (median time since treatment 84 months, mean LVEF 52%) were compared with 42 matched controls [54] in another ECVbased study; ECV was elevated in patients who had been treated with anthracyclines, particularly those with LV diastolic dysfunction.…”