We generalize several topological indices and introduce the general degree distance of a connected graph G. For a, b ∈ R, the general degree distance)] b and dG(v, w) is the distance between v and w in G. We present some sharp bounds on the general degree distance for multipartite graphs and trees of given order, graphs of given order and chromatic number, graphs of given order and vertex connectivity, and graphs of given order and number of pendant vertices.