Degree and clinical relevance of sensitization to common allergens among adults: a population study in Helsinki, Finland

Pallasaho, Paula; Rönmark, Eva; Haahtela, Tari; Sovijärvi, Anssi; Lundbäck, Bo

doi:10.1111/j.1365-2222.2006.02460.x

Cited by 90 publications

(104 citation statements)

References 30 publications

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“…In the present study, BHR was associated with current respiratory symptoms and atopy. Atopy prevalence was 37%, and 22% had multiple sensitisations, in accordance with incidences of 34-47% and 16-42% among the general population, respectively [34].…”

Section: Thoracic Surgerymentioning

confidence: 66%

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Repaired oesophageal atresia: respiratory morbidity and pulmonary function in adults

Sistonen¹,

Malmberg²,

Malmström³

et al. 2010

European Respiratory Journal

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117

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Although after oesophageal atresia (OA) repair in infancy, respiratory problems are common, their natural history remains unclear. We assessed morbidity, pulmonary function (PF), and bronchial hyperresponsiveness (BHR) in adults with repaired OA respiratory.588 patients who underwent surgery for OA during 1947-1985 were identified and those 262 who were alive and had their native oesophagus were included. Respiratory symptoms and respiratory symptom-related quality of life (RSRQoL) were assessed by questionnaire and interview, and the patients underwent spirometry, a histamine challenge test, and an exhaled nitric oxide test. For the questionnaires, we added 287 carefully matched general populationderived controls.Among the 101 (58 male) patients, median age 36 yrs (range 22-56 yrs), respiratory morbidity was significantly increased compared to controls. Patients had more respiratory symptoms and infections, as well as asthma and allergies, and more often impaired RSRQoL (p,0.001 for all). PF tests revealed restrictive ventilatory defect in 21 (21%) patients, obstructive ventilatroy defect in 21 (21%) patients, and both in 36 (36%) patients. A total of 41 (41%) had BHR, and in 15 (15%), it was consistent with asthma. The most significant risk factors for restrictive ventilatory defect were thoracotomy-induced rib fusions (OR 3.4, 95% CI 1.3-8.7; p50.01) and oesophageal epithelial metaplasia (OR 3.0, 95% CI 1.0-8.9; p50.05).After repair of OA, respiratory-related morbidity, restrictive ventilatory defect and BHR extended into adulthood. Nearly half the patients had BHR and over half had a restrictive ventilatory defect. Thoracotomy-induced rib fusions and gastro-oesophageal reflux-associated oesophageal epithelial metaplasia were the strongest risk factors for restrictive ventilatory defect.

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Section: Thoracic Surgerymentioning

confidence: 66%

“…The level of serum IgE was determined based on the standard values of our laboratory, 0-110 kU?L -1 for adults. [34]. Level of significance was set at p,0.05.…”

Section: Atopymentioning

confidence: 99%

Repaired oesophageal atresia: respiratory morbidity and pulmonary function in adults

Sistonen¹,

Malmberg²,

Malmström³

et al. 2010

European Respiratory Journal

Self Cite

117

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“…This BHR study sample represents well the original study cohort from 1996 in terms of age, sex and prevalence of asthma, respiratory symptoms, and smoking habits [15]. The age range was 26-66 years (mean 47 years) and 58% were female.…”

Section: Study Cohortmentioning

confidence: 87%

“…Of the participants, 1200 were randomly invited to participate in the FinEsS II clinical study, and half of those (n5600) were randomly selected to take part in this BHR study. The participation rate for the FinEsS II clinical study was 54% (n5643) [15] and for the BHR study 45.4% (n5292).…”

Section: Study Cohortmentioning

confidence: 99%

Dose-dependent association of smoking and bronchial hyperresponsiveness

et al. 2013

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Our aim was to study the association of smoking habits and environmental tobacco smoke (ETS) exposure with bronchial hyperresponsiveness (BHR).A random sample of 292 adults was examined using a structured interview, spirometry, skin prick tests, exhaled nitric oxide fraction (FeNO) and bronchial histamine challenge.A large majority of subjects with BHR were smokers or ex-smokers. Starting to smoke before 20 years of age was significantly associated with BHR, as was current smoking, quantity of smoking and ETS exposure. The severity of BHR increased significantly with increasing pack-years of exposure (p,0.001). Current smokers with decreased lung function were at a particularly high risk of BHR. Impaired forced expiratory volume in 1 s and mean maximal expiratory flow were independent determinants for more severe BHR, regardless of age. In multivariate analysis, smoking remained an independent determinant for BHR after adjustment for impaired lung function and other covariates: o15 pack-years yielded an odds ratio of 3.00 (95% CI 1.33-6.76) for BHR. The association between BHR and FeNO was dependent on smoking habits.The results indicate that smoking is a significant risk factor for BHR, with a dose-dependent pattern, and that the severity of BHR increases with pack-years. The findings strongly suggest assessment of smoking habits in subjects with BHR. @ERSpublications Bronchial hyperresponsiveness is dose-dependently linked to smoking; severity increases with pack-years

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“…There are important regional differences. Most patients are sensitized to many different pollen species (361). Surprisingly, pollen sensitization is lower in rural than in urban areas, whereas the pollen counts are higher in the country (362).…”

Section: Other Mitesmentioning

confidence: 99%